6results about How to "Overcome risk" patented technology

This invention relates to the field of grouting technology, specifically disclosing an adaptive micro-expansion organic-inorganic hybrid grouting and sealing material and its preparation method, which consists of two components, A and B: Component A is a pumpable viscous liquid, comprising the following components by weight: 90-110 parts of castor oil-based polyurethane prepolymer, 5-15 parts of sulfonate-modified nano-montmorillonite, 8-15 parts of plasticizer, and 3-8 parts of functional nanofibers; Component B is a free-flowing solid powder, which is a microencapsulated water-based curing agent, used in an amount of 10-30 parts by weight. This invention utilizes the ordered interlayer water absorption characteristics of sulfonate-modified nano-montmorillonite to achieve mild and controllable micro-expansion upon contact with water, effectively overcoming the risks of excessive internal stress and structural damage caused by the violent and uncontrollable foaming of traditional hydrophilic materials, ensuring the safety and effectiveness of filling in a closed base plate environment.

This invention discloses a large-arc bend injection mold and molding method, belonging to the field of injection molding technology. The mold includes a moving mold, a fixed mold, and a core mold with a circular arc core; it also includes a demolding drive mechanism for driving the core mold and product to generate a first displacement away from the fixed mold; and a pointer-type rotary demolding mechanism, which includes a pointer push rod and a push ring rotating around the axis of the circular arc core. During demolding, after the product is lifted with the core mold, the pointer push rod drives the push ring to swing along the circular arc path to push the product out. This invention also reduces the covering force by performing pre-demolding through an assisted demolding mechanism and ensures the stability of the core mold during injection molding using a core positioning mechanism. This invention replaces the traditional hot bending process with one-time injection molding, solving the problems of low production efficiency, poor roundness, and easy cracking caused by thermal stress in existing technologies for large-arc bend pipes, significantly improving the geometric accuracy and operational reliability of the product, and is particularly suitable for ultra-high voltage converter valve cooling system pipelines.

The invention relates to the field of physical testing technologies and systems, and discloses a bridge steel structure defect nondestructive testing system based on infrared thermal imaging, which comprises an unmanned aerial vehicle integrated with an infrared thermal imaging detection device and a ground computing station. The unmanned aerial vehicle flies along a planned path, transient thermal excitation is applied through a thermal excitation device, and dynamic thermal response data of the surface of a pre-coated infrared coating is collected by synchronously utilizing an infrared thermal imager. And the ground computing station performs space-time fusion preprocessing on the returned data to obtain a standardized panoramic temperature field image, and inputs the standardized panoramic temperature field image into a convolutional neural network model which fuses physical mechanism constraints and has an online self-optimization function for intelligent analysis. According to the method, signals are enhanced through the coating, efficient inspection is achieved through the unmanned aerial vehicle, the recognition precision and generalization ability are guaranteed through the physical information fusion model, continuous evolution is achieved in combination with online self-optimization, and a high-sensitivity, full-automatic and quantitative bridge steel structure defect intelligent detection solution is formed.

The invention relates to the technical field of biological medicine, and discloses a multi-modal data analysis method for drug screening safety evaluation. By setting experiment duration and sampling intervals, multi-modal data such as genes and metabolites are collected from a drug treatment group and a control group at multiple time points, dimension standardization is performed on the two groups of data based on statistical characteristics of the control group, a comprehensive state vector is constructed, state changes of adjacent time points are utilized to form a discrete time differential component and a state evolution function, and a state evolution function is established. The method comprises the following steps: generating two groups of theoretical trajectories through initial state iteration, comparing the theoretical trajectories with actual observation at each time point to evaluate a multi-dimensional error, performing double accumulation in time and state dimensions to obtain a toxicity index of a drug treatment group and a baseline toxicity index of a control group, and calculating a dimensionless safety score for drug grading according to the relationship between the toxicity index and the baseline toxicity index. Therefore, the limitation of dependence on a single index or a single time point is overcome, and the multi-modal data fusion and full-cycle toxicity quantification capabilities are improved.

The application discloses a lacrimal passage epithelial organoid and a construction method and application thereof, and the construction method comprises the following steps: S1, preparation of a three-dimensional biomimetic support; S2, acquisition of lacrimal passage epithelial stem cells; and S3, construction and culture of the organoid. The PCL / GEL nanofiber support constructed by the electrospinning technology is combined with Matrigel coating, the extracellular matrix (ECM) microenvironment of the in-vivo lacrimal passage mucosa is successfully simulated, and the technical difficulties that stem cells are prone to aging and differentiation direction disorder in traditional two-dimensional culture are fundamentally solved. This breakthrough result promotes the lacrimal passage tissue engineering from simple 'cell adhesion growth' to a new height of'structure-function synchronous reconstruction', and provides a double technical guarantee of seed cells and tissue engineering supports for solving the clinical core pain point of postoperative scar adhesion and re-occlusion of the lacrimal passage obstruction disease.