Silver dihydrogen citrate compositions comprising a second antimicrobial agent

a technology of silver dihydrogen citrate and composition, applied in the field of antimicrobial compositions, can solve the problems of prolonging the antimicrobial effect, irritating or even toxic, and not being effective against some gram-negative bacteria

Inactive Publication Date: 2005-09-15
PURE BIOSCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0017] The invention also provides a method of conferring an antimicrobial effect on a substrate. The method includes applying an antimicrobial composition to a substrate. The a...

Problems solved by technology

However, benzalkonium chlorides are not effective against some Gram-negative bacteria, such as Pseudomonas.
While such compounds are beneficial at relatively low concentrations, at higher concentrations they can be irritating or even toxic.
Also, quaternary compounds tend to dissipate in the environment quickly, and thus tend not to provide extended antimicrobial effects when applied to solid surfaces and other substrates.
While oxidizing agents are very effective disinfectants, they tend to degrade quickly in the environment, and thus are not suitable for providing antimicrobial effects over an extended period of time.
While not as irritating as tinctures, when used on skin iodopho...

Method used

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  • Silver dihydrogen citrate compositions comprising a second antimicrobial agent
  • Silver dihydrogen citrate compositions comprising a second antimicrobial agent

Examples

Experimental program
Comparison scheme
Effect test

example 1

Production of Silver Dihydrogen Citrate Stock Solution

[0053] Water was introduced into a reverse osmosis unit, passing through a semi-permeable membrane to remove impurities and producing deionized water. Anhydrous 99% pure citric acid was mixed with the water to produce 200 gallons of a 20% (wt / vol) (796 g citric acid per gallon water) solution. The 200 gallons of 20% citric acid were directed into an ion chamber containing having positive and negative electrodes, each consisting of 200 troy ounces of 999 fine silver. The positive and negative electrodes were spaced at least 2.0 mm apart, allowing the citric acid solution to pass between the two electrodes. An ion generation controller (IGC) power supply including a positive and a negative conductor was attached to the positive and negative electrodes. The IGC applied a current of 5 amps at 17 volts, pulsed every 9 seconds, with a polarity change at 1 minute intervals. Throughout the process, the electrode gap was adjusted in orde...

example 2

Production of a Composition of Silver Dihydrogen Citrate and a Quaternary Ammonium Compound, an Oxidizing Agent or a Halogen Compound

[0055] (a) A scented, colored intermediate composition: In a 1,000 ml Pyrex™ glass flask, there were combined the ingredients set forth in Table 1 in the indicated proportions:

TABLE 1IngredientProportionPure Pharmaceutical-Grade98.882%WaterQuaternary Ammonia 80%0.300%ConcentrateTriton X-100 ™ surfactant0.500%Non-toxic Scent0.300%Non-toxic color0.015%

[0056] (b) Scented, non-colored composition: In a 1,000 ml Pyrex™ glass flask, there were combined the ingredients listed in Table 2 in the indicated proportions:

TABLE 2IngredientProportionPure Pharmaceutical-Grade98.897%WaterQuaternary Ammonia 80%0.300%ConcentrateTriton X-100 ™ surfactant0.500%Non-toxic Scent0.300%

[0057] (c) Non-scented, colored composition: In a 1,000 ml Pyrex™ glass flask, there were combined the ingredients listed in Table 3 in the indicated proportions:

TABLE 3IngredientProportio...

example 3

Antimicrobial Effect of the Composition from Example 3

[0060] An E. coli test strain (E. coli PIPSA, German H.) was grown at 35° C. for 24 hours. The cells were harvested by centrifugation for 10 minutes and were washed twice with Butterfield's Phosphate Buffer (BPB pH. 7.2). The cells were then re-suspended in BPB to obtain a cell suspension of approximately 108 CFU / ml. (Target inoculum levels were approximately 106 CFU / ml in the final test solution).

[0061] Three sets of two non-porous glass slides were provided. For each set of test slides, one was treated with the test solution in Example 3 and the other slide was treated with the intermediate test solution from Example 3. Each slide was then inoculated with E. coli.

[0062] After inoculation, the test slides were then stored for periods of 1 and 24 hours, then plated out at the indicated time period and incubated for a period of 24 hours. A score of Pass indicates no bacterial growth. A score of Fail indicates bacterial growth. ...

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Abstract

Compositions comprising silver dihydrogen citrate in combination with a second antimicrobial compound are provided. The second antimicrobial compound may be quaternary ammonia, an oxidizer or a halogen species, such as chlorine, bromine or iodine. Methods of using the antimicrobial composition provide superior antimicrobial effects.

Description

[0001] This invention claims priority from U.S. provisional application Ser. No. 60 / 498,347, filed Aug. 28, 2003, which is incorporated herein by reference in its entirety.FIELD OF THE INVENTION [0002] The invention relates to antimicrobial compositions and their methods of use. In particular, the invention relates to silver dihydrogen citrate compositions comprising quaternary amines, an oxidizing agent or a halogen compound, and methods of using the compositions to confer an antimicrobial effect on various substrates. BACKGROUND OF THE INVENTION [0003] A large number of antimicrobial compounds are known. Compounds that kill or prevent the spread of microbes have been used for a variety of purposes and in numerous products to prolong product shelf-life, and to confer antimicrobial benefits to end-users, their possessions and their environments. Some antimicrobial compounds that may be mentioned include quaternary ammonium compounds, oxidizing agents and halogen compounds. [0004] Qu...

Claims

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Application Information

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IPC IPC(8): A01N33/12A01N37/00A01N55/02A01N59/00A61KA61K31/28A61L15/16
CPCA01N31/02A01N37/36A01N59/16C07C59/265A01N25/34A01N33/12A01N59/00A01N59/02A01N2300/00A01N25/22Y10T442/2525A61P31/00A61K31/28
Inventor ARATA, ANDREW B.
Owner PURE BIOSCI
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