Short peptide for inhibiting Shiga toxin and application thereof

A Shiga toxin and short peptide technology, applied in the direction of peptides, anti-toxins, peptide/protein components, etc., to achieve good application prospects, excellent binding kinetics, and the effect of inhibiting toxicity
CN101016332AActive Publication Date: 2007-08-15MICROBE EPIDEMIC DISEASE INST OF PLA MILITARY MEDICAL ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
MICROBE EPIDEMIC DISEASE INST OF PLA MILITARY MEDICAL ACAD OF SCI
Publication Date
2007-08-15

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Abstract

The invention discloses a making method of short peptide to inhibit shigellosis with amino acid as list 1, which is characterized by the following: adding chemical group, amino acid, peptide, protein, PEG, marked material to N and C ends to do kinds of chemical or biological decoration; optimizing the stability or other applying property and using scale; fitting for treat shigellosis, enterorrhagia escherichia coli O157 and cholera vibrio.
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Description

technical field

[0001] The present invention relates to a biological toxin inhibitor, in particular to a short peptide capable of inhibiting Shiga toxin, and also to a preparation method and application of the short peptide. Background technique

[0002] Shiga toxin (Stx) is a kind of bacterial exotoxin with enterotoxicity, cytotoxicity and neurotoxicity produced by enteropathogenic bacteria, and it is the most common cause of emerging enteropathogens such as acute bacillary dysentery, cholera O139, O157:H7, etc. A key potent virulence factor. Clinically, it causes serious complications such as hemorrhagic colitis (hemorrhagic colitis, HC), thrombotic thrombocytopenic purpura (TTP), and hemolytic uremic syndrome (HUS) with a mortality rate as high as 80-90%. Such diseases kill millions of people worldwide.

[0003] At present, there are no specific and effective preventive products and emergency treatment drugs for Shiga toxin. Antibiotic treatment commonly used in clinic...

Claims

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