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Chitosan hydrogel for antibacterial dressing and preparation method thereof

A technology of chitosan and sugar water, which is applied in medical science, absorbent pads, bandages, etc., can solve the problems of poor antibacterial durability and doubtful antibacterial safety, and achieve enhanced antibacterial effect, strong antibacterial ability, and high water absorption.

Inactive Publication Date: 2014-07-16
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention provides a kind of antibacterial dressing with good drug resistance, good antibacterial property, antibacterial lasting, water absorption rate etc. Chitosan hydrogel with high and good mechanical properties for antibacterial dressings

Method used

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  • Chitosan hydrogel for antibacterial dressing and preparation method thereof
  • Chitosan hydrogel for antibacterial dressing and preparation method thereof
  • Chitosan hydrogel for antibacterial dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] A chitosan hydrogel for antibacterial dressing, calculated in parts by weight, its composition and content are as follows:

[0047] Chitosan 2 parts

[0048] 5 parts of water-soluble monomer

[0049] Antibacterial agent polyhexamethylene guanidine hydrochloride 1 part

[0050] Cross-linking agent 0.015 parts

[0051] condensing agent 1 part

[0052]Activator 1 part

[0053] Initiator 0.1 parts

[0054] 109 parts of dimethyl sulfoxide;

[0055] The chitosan has a degree of deacetylation of 80.0 and a viscosity of 50-800mPa.s;

[0056] Described water-soluble monomer is methacrylic acid;

[0057] The crosslinking agent is N,N-methylenebisacrylamide;

[0058] The condensing agent is diisopropylcarbodiimide (DIC);

[0059] The activator is 1-hydroxybenzotriazole (HOBt);

[0060] Described initiator is potassium persulfate.

[0061] The preparation method of above-mentioned a kind of antibacterial dressing chitosan hydrogel specifically comprises the steps:

[00...

Embodiment 2

[0071] A chitosan hydrogel for antibacterial dressing, calculated in parts by weight, its composition and content are as follows:

[0072] Chitosan 3 parts

[0073] 6 parts of water-soluble monomer

[0074] Antibacterial agent polyhexamethylene guanidine hydrochloride 1.5 parts

[0075] Cross-linking agent 0.02 parts

[0076] condensing agent 1 part

[0077] Activator 1 part

[0078] Initiator 0.15 part

[0079] 113.5 parts of dimethyl sulfoxide;

[0080] The chitosan has a degree of deacetylation of 85.0 and a viscosity of 50-800mPa.s;

[0081] Described water-soluble monomer is acrylic acid;

[0082] Described linking agent is glutaraldehyde;

[0083] The condensing agent is 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDCI);

[0084] The activator is 1-hydroxybenzotriazole (HOBt);

[0085] The initiator is ammonium persulfate.

[0086] The preparation method of above-mentioned a kind of antibacterial dressing chitosan hydrogel specifically comprises the steps: ...

Embodiment 3

[0093] A chitosan hydrogel for antibacterial dressing, calculated in parts by weight, its composition and content are as follows:

[0094] Chitosan 4 parts

[0095] 10 parts of water-soluble monomer

[0096] Antibacterial agent polyhexamethylene guanidine hydrochloride 3 parts

[0097] Cross-linking agent 0.045 parts

[0098] Condensing agent 1.5 parts

[0099] Activator 1.5 parts

[0100] Initiator 0.25 parts

[0101] 127 parts of dimethyl sulfoxide;

[0102] The chitosan has a degree of deacetylation of 90.0 and a viscosity of 50-800mPa.s;

[0103] Described water-soluble monomer is methacrylic acid;

[0104] The crosslinking agent is N,N-methylenebisacrylamide;

[0105] The condensing agent is diisopropylcarbodiimide (DIC);

[0106] The activator is 4-N,N-lutidine (DMAP);

[0107] Described initiator is potassium persulfate.

[0108] The preparation method of above-mentioned a kind of antibacterial dressing chitosan hydrogel specifically comprises the steps:

[...

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Abstract

The invention discloses a chitosan hydrogel for an antibacterial dressing and a preparation method thereof. The chitosan hydrogel for the antibacterial dressing comprises, by weight, 2 to 6 parts of chitosan, 5 to 20 parts of a water-soluble monomer, 1 to 5 parts of an antibacterial agent polyhexamethyleneguanidine hydrochloride, 0.015 to 0.1 part of a cross-linking agent, 1 to 5 parts of a condensing agent, 1 to 5 parts of an activator, 0.1 to 0.5 part of an initiator and 109 to 145 parts of dimethyl sulfoxide. The preparation method comprises the following steps: introducing a carboxyl group on chitosan in the manner of free radical polymerization; subjecting the carboxyl group introduced on chitosan and the antibacterial agent polyhexamethyleneguanidine hydrochloride to an amidation reaction by using the condensing agent and the activator; and uniformly mixing chitosan for the antibacterial dressing with the cross-linking agent and pouring an obtained mixture into a die for a reaction so as to obtain the hydrogel with good drug resistance, good antibacterial property, a lasting antibacterial effect, high water absorption and good mechanical properties.

Description

technical field [0001] The invention relates to an antibacterial dressing, in particular to a chitosan hydrogel suitable for treating burns, scalds and open mechanical wounds and a preparation method thereof. Background technique [0002] Medical dressings are a key material in clinical wound management. The main function of traditional dressings is to cover the wound and prevent wound infection. In the 21st century, modern medical dressings have gradually replaced traditional dressings. Compared with traditional dressings, modern dressings, especially hydrogel dressings, have good mechanical strength and can resist wound damage from mechanical factors (such as injury, collision, etc.), pollution and chemical stimulation (due to the wounds at the joints before dressing When the patient moves, it is mainly affected by tension. If the mechanical properties (such as tensile strength) are low, the hydrogel dry film will easily break, so the strength of the hydrogel dressing is...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/42A61L15/44C08G81/02C08F251/00C08F220/06C08J3/24
Inventor 吴蓁宋羽顾顺超王玮媛盛奥奇张英强
Owner SHANGHAI INST OF TECH
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