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Preparation method of bacterial cellulose composite chitosan moist antimicrobial dressing

A composite chitosan wetness and bacterial cellulose technology, which is applied in the fields of medical science, textiles, papermaking, bandages, etc., can solve the problems of performance degradation and application limitations of bacterial cellulose materials, and achieve low cost and simple preparation process , the effect of prolonging the use time

Active Publication Date: 2015-03-25
钟春燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing composite methods often destroy the three-dimensional nano-network structure of bacterial cellulose itself, resulting in the degradation of some properties of the composite material due to the destruction of the bacterial cellulose structure, such as: mechanical strength, water absorption performance, air permeability, etc.
The destruction of these properties will limit the application of bacterial cellulose materials in the field of dressings

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (1) Activate Acetobacter xylinum to prepare seed mash, then evenly drop the seed mash with a strain concentration of 10% on the sterilized polyester non-woven fabric or woven fabric, and add a small amount of fermentation medium after 5 minutes . The amount of fermentation medium added is controlled so that the distance from the liquid surface of the medium to the bottom of the culture container is 5 mm, the temperature of the fermentation culture is 25° C., and the time is 48 hours. Then add fermentation medium, wherein the amount of fermentation medium added is controlled at a distance of 20 mm from the liquid surface of the medium to the bottom of the culture container, the fermentation temperature is 30° C., and the culture time is 6 days. The fermentation product is purified to obtain bacterial cellulose composite polyester non-woven fabric or woven fabric membrane material. The upper layer is a bacterial cellulose film, the lower layer is a non-woven fabric or a ...

Embodiment 2

[0023] (1) Activate Acetobacter xylinum to prepare seed mash, then evenly drop the seed mash with a strain concentration of 30% on the sterilized nylon non-woven fabric or woven fabric, and add a small amount of fermentation medium after 6 minutes . The amount of fermentation medium added is controlled so that the distance from the liquid surface of the medium to the bottom of the culture container is 8 mm, the temperature of the fermentation culture is 28° C., and the time is 40 h. Then add fermentation medium, wherein the amount of fermentation medium added is controlled at a distance of 25 mm from the liquid surface of the medium to the bottom surface of the culture container, the temperature of the fermentation culture is 32° C., and the culture time is 6 days. The fermentation product is purified to obtain bacterial cellulose composite nylon non-woven fabric or woven fabric membrane material. The upper layer is a bacterial cellulose film, the lower layer is a non-woven f...

Embodiment 3

[0026] (1) Activate Acetobacter xylinum to prepare seed mash, and then evenly drop the seed mash with a strain concentration of 60% on the sterilized viscose fiber non-woven or woven cloth, and add a small amount of fermentation after 7 minutes Medium. The amount of fermentation medium added is controlled so that the distance from the liquid surface of the medium to the bottom of the culture container is 10 mm, the temperature of the fermentation culture is 30° C., and the time is 32 hours. Then add fermentation medium, wherein the amount of fermentation medium added is controlled at a distance of 30 mm from the liquid surface of the medium to the bottom of the culture vessel, the temperature of the fermentation culture is 34° C., and the culture time is 5 days. The fermentation product is purified to obtain bacterial cellulose composite viscose fiber non-woven fabric or woven fabric membrane material. The upper layer is a bacterial cellulose film, the lower layer is a non-wo...

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PUM

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Abstract

The invention discloses a preparation method of a bacterial cellulose composite chitosan moist antimicrobial dressing, and relates to medical equipment and the technical field of a preparation of the medical equipment. The preparation method comprises the following steps that a seed mash prepared from activating a strain is dropped on a non-woven fabric or a woven fabric, and a small amount of fermentation culture media are added to be cultured for 12 to 48 hours, then the fermentation culture media are supplemented, and culturing is carried out for 3 to 6 days, and a fermentation product is taken out, the fermentation product is purified to obtain a bacterial cellulose composite non-woven fabric or a woven fabric membrane material, and an electrostatic spinning method is used for ejecting a chitosan solution from a spinneret, trickles of the ejected chitosan solution are ejected to the bacterial cellulose composite non-woven fabric or the woven fabric membrane material containing anhydrous ethanol and / or water, finally the bacterial cellulose composite chitosan moist antimicrobial dressing is obtained after the bacterial cellulose composite non-woven fabric or the woven fabric membrane material containing anhydrous ethanol and / or water is treated. The preparation method disclosed by the invention is simple and easy in preparation processes, convenient to operate, and low in cost, and the prepared moist antimicrobial dressing can cure chronic unhealed traumas, pressure acute refractory wounds, burns, and a large area of soft tissue defects and / or infections.

Description

technical field [0001] The invention relates to the technical field of medical equipment and its preparation, in particular to a method for preparing a bacterial cellulose composite chitosan moist antibacterial dressing. Background technique [0002] Modern medical theory proves that the wound healing process is a continuous dynamic process, which is a process of interaction between cells and cells, cells and cell matrix, and soluble media. From the perspective of the development of medical dressings, with the popularization of "wet therapy" theory and practice, wet dressings have received increasing attention in the world's medical and health fields. The application of "wet therapy" will keep the wound in a warm and humid environment. In this environment, bacteria multiply rapidly in the wound, making the wound an important source of cross-infection in the ward. In order to control the bacteria on the wound and prevent their spread, it is necessary to add antibacterial sub...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/44D04H13/00
Inventor 钟春燕其他发明人请求不公开姓名
Owner 钟春燕
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