Medical cationic polymer antimicrobial dressing and preparation method

A cationic polymer and polymer technology, applied in the field of biomedicine, can solve the problems of weak antibacterial persistence, easy endocytosis by human cells, allergic reactions, etc., achieve good water absorption and moisturizing performance, not easy to enter the human body, and biocompatibility good sex effect

Pending Publication Date: 2021-03-26
FIRST HOSPITAL AFFILIATED TO GENERAL HOSPITAL OF PLA
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

However, short-chain guanidinium salt wounds will be endocytosed by mammalian cells, leading to the accumulation of local antibacterial agents. After endocytosis, it may lead to rejection of the body, local inflammatory reactions, resulting in local pigmentation, or allergic reactions; small molecule antibacterial agents are mainly used , the release is too fast, and the antibacterial persistence is not strong; salts are difficult to process, uncertain, and there is still a risk of entering the circulatory system and reaching sensitive organs when used on wounds
[0005] The previous medical guanidine antibacterial agent dressings loaded small molecule guanidine salts through simple physical soaking method o

Method used

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  • Medical cationic polymer antimicrobial dressing and preparation method
  • Medical cationic polymer antimicrobial dressing and preparation method
  • Medical cationic polymer antimicrobial dressing and preparation method

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preparation example Construction

[0060] A kind of cationic polymer medical antibacterial dressing preparation method, it is characterized in that, the step of described method comprises:

[0061] a. prepare chitosan solution;

[0062] b. Prepare polyvinyl alcohol solution;

[0063] c. the chitosan solution made by step a is mixed with the polyvinyl alcohol solution made by step b, so that the mass fraction ratio of chitosan in the mixed solution is 1~5, the mass fraction ratio of polyvinyl alcohol is 0.05~0.75;

[0064] d. adding polyhexamethyleneguanidine hydrochloride to the solution prepared in step c and mixing, so that the mass-number ratio of hexamethyleneguanidine hydrochloride in the solution is 0.05 to 0.4;

[0065] e. Place the solution prepared in step d in a container, and gradually freeze at 4°C, -20°C, and -80°C in sequence;

[0066] f. the solution made by step e is placed into a vacuum freeze dryer to freeze-dry to become a porous sponge.

[0067] To achieve the preferred antimicrobial dre...

Embodiment 1

[0081] A cationic polymer medical antibacterial dressing is a polymer comprising polyhexamethyleneguanidine hydrochloride, chitosan and polyvinyl alcohol, and the components of the antibacterial dressing include:

[0082] Chitosan with a ratio of mass and number of parts of 2;

[0083] The ratio of mass and number is 0.25 polyvinyl alcohol;

[0084] Polyhexamethylene hydrochloride with a ratio of parts by mass of 0.1.

[0085] The preparation method of cationic polymer medical antibacterial dressing is that the steps include:

[0086] a. Prepare 100 mL of chitosan solution with a concentration of 2%. Take 2 g of chitosan, add 100 mL of ultrapure water, and stir mechanically at 1500 rpm for 5 minutes. Since chitosan is usually insoluble in water, add 2 mL of ice Acetic acid impels its dissolution to prepare a 2% chitosan solution;

[0087] b. Prepare a polyvinyl alcohol solution with a concentration of 5%. Take 5g of polyvinyl alcohol, add 100 mL of ultrapure water, and ster...

Embodiment 2

[0095] A cationic polymer medical antibacterial dressing, this embodiment adjusts the content of polyhexamethyleneguanidine hydrochloride for embodiment 1. In the present embodiment, the composition of antibacterial dressing comprises:

[0096] Chitosan with a mass and number ratio of 2,

[0097] The polyhexamethylene hydrochloride that the mass fraction ratio is 0.05,

[0098] The polyvinyl alcohol with a mass / number ratio of 0.25.

[0099] In the preparation method of cationic polymer medical antibacterial dressing:

[0100] In step d, a polyhexamethyleneguanidine hydrochloride solution with a concentration of 20% is prepared, and 0.25 ml of a 20% polyhexamethyleneguanidine hydrochloride solution is added to the solution prepared in step c, so that the The mass fraction ratio of hexamethyleneguanidine hydrochloride to chitosan in the solution is 0.05:2.

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Abstract

The invention relates to a medical cationic polymer antimicrobial dressing and a preparation method. The antimicrobial dressing is a polymer including polyhexamethylene guanide hydrochloride, chitosanand polyvinyl alcohol, and the antibacterial dressing comprises the following components in parts by weight: 1-5 parts of chitosan, 0.05-0.4 part of polyhexamethylene guanide hydrochloride and 0.05-0.75 part of polyvinyl alcohol. The antimicrobial dressing has the beneficial effects that the long-chain guanidine polyhexamethylene guanide hydrochloride and the polymer chitosan are selected to synergistically exert the antimicrobial ability, and the dressing is processed by utilizing good mechanical properties of the long-chain guanidine polyhexamethylene guanide hydrochloride and the polymer chitosan; the antimicrobial dressing is not prone to fall off, is not prone to enter the human body, and a 3D porous spongy dressing can be prepared, so that the dressing has good water absorption andmoisture retention properties; and the antimicrobial dressing can have a local broad-spectrum antimicrobial property, is not prone to develop drug resistance, has low toxicity, has a good effect of promoting wound healing, provides a mechanical protection effect for a wound, absorbs exudates, keeps the wound moist and has high biocompatibility, and the drug is not prone to enter blood.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a cationic polymer medical antibacterial dressing and a preparation method thereof. Background technique [0002] Wound infection can cause a variety of serious complications, such as sepsis, multiple organ failure, etc. Topical application of antibacterial dressings is currently one of the main methods for preventing and treating infected wounds. Antibacterial dressings are classified according to their effective antibacterial components. Current research hotspots include antibiotics, nano-metal particles, and polymers. [0003] There are thousands of antibiotics that have been discovered, but those that can be used systemically are very limited. Antibiotics act on specific targets of bacteria and are prone to drug resistance; local administration still has the risk of toxicity, entering the body, and developing drug resistance. Nano-metal particles are representative of...

Claims

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Application Information

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IPC IPC(8): A61L15/24A61L15/28A61L15/42A61L15/44A61L15/46
CPCA61L15/24A61L15/28A61L15/44A61L15/46A61L15/42A61L15/425A61L2300/204A61L2300/404C08L29/04C08L5/08
Inventor 柴家科岳晓彤刘玲英迟云飞胡泉尹会男吴育寿畅阳白海良韩绍芳王晓腾刘翔宇冯瑞
Owner FIRST HOSPITAL AFFILIATED TO GENERAL HOSPITAL OF PLA
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