Polyhexamethyleneguanidine hydrochloride iodine medicine bath liquid and preparation method thereof

A technology of polyhexamethyleneguanidine hydrochloride and medicated bath liquid, which is applied in the fields of pharmaceutical formulations, cosmetic preparations, dressing preparations, etc., which can solve the problems of weak bactericidal efficacy, reduced bactericidal ability, and high transportation costs of products, and achieve Excellent decontamination, high bactericidal effect, good stability

Active Publication Date: 2014-03-26
上海奶牛研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the main reason for restricting the popularization and application of iodophor bath liquids is that the bactericidal effect of the products is not strong and the stability is poor.
In general use, it can only be diluted by 2 times to 5 times, and the volume is large and the transportation cost is high.
In addition, precipitation or stratification often occurs during storage (several months), and the bactericidal ability is reduced

Method used

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  • Polyhexamethyleneguanidine hydrochloride iodine medicine bath liquid and preparation method thereof
  • Polyhexamethyleneguanidine hydrochloride iodine medicine bath liquid and preparation method thereof
  • Polyhexamethyleneguanidine hydrochloride iodine medicine bath liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Weigh or measure each component according to the following proportions:

[0029]

[0030] (2) Preparation of polyhexamethylene guanidine iodine hydrochloride bath solution: add polyhexamethylene guanidine hydrochloride, detergent and skin care agent to appropriate amount of water according to the above-mentioned component amounts, and heat in the generating device To 45-50°C, start the stirrer. After mixing uniformly, add iodine, potassium iodide, and potassium iodate, and continue to stir at this temperature to make it fully dissolved. Then, a small amount of sodium tripolyphosphate and citric acid are added, and stirring is continued at a constant temperature until the components are completely dissolved to obtain the polyhexamethylene guanidine iodine hydrochloride bath solution.

Embodiment 2

[0032] (1) Weigh or measure each component according to the following proportions:

[0033]

[0034] (2) Preparation of polyhexamethylene guanidine iodine hydrochloride bath solution: add polyhexamethylene guanidine hydrochloride, detergent and skin care agent to appropriate amount of water according to the amount of the above components, and place in the generating device for adding Warm to 65-70°C and start the stirrer. After mixing uniformly, add iodine, potassium iodide, and potassium iodate, and continue to stir at this temperature to make it fully dissolved. Then, a small amount of sodium tripolyphosphate and citric acid are added, and stirring is continued at a constant temperature until the components are completely dissolved to obtain the polyhexamethylene guanidine iodine hydrochloride bath solution.

Embodiment 3

[0036] (1) Weigh or measure each component according to the following ratio:

[0037]

[0038] (2) Preparation of polyhexamethylene guanidine iodine hydrochloride bath solution: add polyhexamethylene guanidine hydrochloride, detergent and skin care agent to appropriate amount of water according to the amount of the above components, and place in the generating device for adding Warm to 58-60°C and start the stirrer. After mixing uniformly, add iodine, potassium iodide, and potassium iodate, and continue to stir at this temperature to make it fully dissolved. Then, a small amount of sodium tripolyphosphate and citric acid are added, and stirring is continued at a constant temperature until the components are completely dissolved to obtain the polyhexamethylene guanidine iodine hydrochloride bath solution.

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Abstract

The present invention relates to a polyhexamethyleneguanidine hydrochloride iodine medicine bath liquid and a preparation method thereof. The polyhexamethyleneguanidine hydrochloride iodine medicine bath liquid comprises the following components, by mass, 0.2-2 parts of iodine, 0.5-5 parts of potassium iodide, 0.1-1 part of potassium iodate, 0.1-1 part of sodium tripolyphosphate, 5-50 parts of polyhexamethyleneguanidine hydrochloride, 1-20 parts of a detergent, 0.5-5 parts of a skin care agent, 0.05-1 part of citric acid, and 15-92.55 parts of water. The preparation method comprises: respectively adding the polyhexamethyleneguanidine hydrochloride, the detergent and the skin care agent to the water, and stirring at a temperature of 45-70 DEG C until mixing is uniform; then adding the iodine, the potassium iodide, and the potassium iodate, and stirring at a temperature of 45-70 DEG C to completely dissolve; and adding the sodium tripolyphosphate and the citric acid, and stirring at a temperature of 45-70 DEG C until all components are completely dissolved to obtain the product. The medicine bath liquid of the present invention has characteristics of high effective iodine content, high sterilization effect and good stability, and is suitable for pastures. The preparation method of the present invention has a characteristic of simple operation, and can be applicable for large-scale production.

Description

Technical field [0001] The invention relates to the field of medicated bath liquid and its preparation, in particular to a medicated bath liquid of polyhexamethylene guanidine iodine hydrochloride and a preparation method thereof. Background technique [0002] Iodophors (Iodophors) is an amorphous complex prepared with a carrier. Iodine is slowly released in the iodophor solution to produce sterilization and disinfection. Its bactericidal effect is long-lasting, the irritation is low, and the coloring effect disappears. The iodine alcohol solution has the shortcomings of sublimation, yellowing and irritation, while retaining its bactericidal effect. Iodophor is generally composed of iodine, carrier, stabilizer and other auxiliary agents. At present, the main reason for restricting the promotion and application of iodophors bath liquids is that the products have poor bactericidal efficacy and poor stability. Generally, it can only be diluted 2 times to 5 times, which is large in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/84A61K8/86A61Q19/10A61K8/20
Inventor 张克春缪德年张臻峥
Owner 上海奶牛研究所有限公司
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