Preparation method of povidone iodine solution and povidone iodine solution prepared by the method

A technology of povidone-iodine and solution is applied in the directions of non-active components of medical preparations, artificially synthesized active components of polymeric materials, pharmaceutical formulations, etc., and can solve the problems of influence, harsh complexation conditions, instability, etc. Simple process, excellent stability, cost control effect

Active Publication Date: 2021-04-02
FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, due to the high activity of iodine, this also has an impact on the stability of iodine preparations
Existing povidone-iodine solutions generally use polyvinylpyrrolidone as a complexing agent, but because the complexation conditions between polyvinylpyrrolidone and iodine are relatively harsh and the reaction process is difficult to control, part of the raw material iodine cannot be completely complexed or complexed. The combined structure is unstable, which will affect the stability of povidone-iodine solution, and this will also have an adverse effect on the disinfection effect of povidone-iodine

Method used

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  • Preparation method of povidone iodine solution and povidone iodine solution prepared by the method
  • Preparation method of povidone iodine solution and povidone iodine solution prepared by the method
  • Preparation method of povidone iodine solution and povidone iodine solution prepared by the method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] (a) 6g of polyvinylpyrrolidone K12 is dissolved in water to obtain a polyvinylpyrrolidone solution for subsequent use;

[0064] (b) 2g potassium iodide is dissolved in water to obtain an iodide solution, which is set aside;

[0065] (c) Add 3g N,N-diethylbenzylamine in the preparation tank, then add 0.5g concentrated sulfuric acid, and stir for 30min; ℃; add 10g of fatty acid methyl ester polyoxyethylene ether, stir evenly, add 0.5g of iodine and iodide solution in turn, and stir for 20min, control the system temperature to 70°C; then, add polyvinylpyrrolidone solution and 3g of glycerin in turn, continue stirring After 45 minutes, stop stirring, cool, add disodium hydrogen phosphate and an appropriate amount of water, adjust the pH to 4.65, and obtain the povidone-iodine solution of Example 1.

Embodiment 2

[0067] (a) Dissolve 4g of polyvinylpyrrolidone K30 in water to obtain a polyvinylpyrrolidone solution for subsequent use;

[0068] (b) 3g of sodium iodide is dissolved in water to obtain an iodide solution, which is set aside;

[0069] (c) Add 2g of pyridine to the preparation tank, then add 0.3g of concentrated sulfuric acid, and stir for 20min; then, add 4g of 30% hydrogen peroxide, and keep stirring for 45min, the temperature of the heat preservation is 50°C; add 8g of n-octanol polyoxygen Vinyl ether JFC, stir evenly, add 0.3g refined iodine and iodide solution in turn, and stir for 15min, control the system temperature at 60°C; then, add polyvinylpyrrolidone solution and 1g glycerin in turn, continue stirring for 45min, stop stirring, cool, add Sodium sulfite and an appropriate amount of water were used to adjust the pH to 4.5 to obtain the povidone-iodine solution of Example 2.

Embodiment 3

[0071] (a) 5g of polyvinylpyrrolidone K17 is dissolved in water to obtain a polyvinylpyrrolidone solution, which is set aside;

[0072] (b) 2.5g potassium iodide is dissolved in water to obtain an iodide solution, which is set aside;

[0073] (c) Add 3g of quinoline in the preparation tank, then add 0.3g of concentrated sulfuric acid, and stir for 30min; then, add 4.5g30% hydrogen peroxide, and keep stirring for 60min, the temperature of the heat preservation is 60°C; add 12g of polylauryl alcohol Oxyethylene ether AEO-9, stir evenly, add 0.6g refined iodine and iodide solution in turn, and stir for 25min, control the system temperature at 60°C; then, add polyvinylpyrrolidone solution and 4g glycerin in turn, continue stirring for 50min, stop stirring, Cool, add disodium hydrogen phosphate and an appropriate amount of water, adjust the pH to 5.5, and obtain the povidone-iodine solution of Example 3.

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Abstract

The invention provides a preparation method of a povidone-iodine solution and the povidone-iodine solution prepared by the method. According to the method provided by the invention, a stabilizing agent is added during the preparation reaction process, so that the stability of the prepared povidone-iodine solution can be effectively improved. Meanwhile, the method provided by the invention has the advantages that the process is simple; the control is easy; the large-scale equipment is not needed; the large-scale industrial production is easy; meanwhile, the povidone-iodine solution provided by the invention has the advantages of high effective iodine content in the solution, high stability and the like.

Description

technical field [0001] The invention relates to the field of disinfection preparations, in particular to a method for preparing a povidone-iodine solution and a povidone-iodine solution prepared by the method. Background technique [0002] Povidone-iodine solution is a disinfectant and antiseptic drug. Its mechanism of action is that after the product contacts the wound or affected area, it can depolymerize and release free iodine to play a bactericidal effect, and at the same time, it is less irritating to tissues. Povidone-iodine solution has a killing effect on various bacteria, spores, viruses, fungi, etc., and is widely used in surgical sites, skin disinfection, treatment of skin diseases, and cow teat soaking. [0003] However, due to the high activity of iodine, this also affects the stability of iodine preparations. Existing povidone-iodine solutions generally use polyvinylpyrrolidone as a complexing agent, but because the complexation conditions between polyvinylpy...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/79A61K47/22A61K47/18A61P31/02
CPCA61K9/08A61K31/79A61K47/18A61K47/22
Inventor 徐奇清李成应周淑贞张庆聂姣
Owner FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD
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