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The invention relates to sobering-up oral liquid comprising the following concretely designed components: 10-20 grams of pueravia flower, 5-10 grams of raisin tree seed, 10-15 grams of olive, 5-10 grams of ebony, 10-15 grams of tuckahoe, 10-20 grams of semen coicis, 3-5 grams of villous anomum, 5-10 grams of tangerine peel, 10-20 grams of red phaseolus bean, 3-5 grams of ginger, 50-100 grams of honey and 1000 milliliters of clear water. The preparation method of the sobering-up oral liquid comprises the following steps: firstly, taking the pueravia flower, the raisin tree seed, the olive, theebony, the tuckahoe, the semen coicis, the villous anomum, the tangerine peel, the red phaseolus bean and the ginger, adding the clear water, decocting with strong fire until boiling, maintaining with slow fire for 10 minutes and filtering out medicative decoction; adding the clear water again, decocting with strong fire until boiling, maintaining with slow fire for 15 minutes and filtering out medicative decoction; blending the decocted medicative decoction of the two times together and concentrating to a required quantity; and cooling to a natural temperature and adding a right amount of honey so as to obtain the sobering-up oral liquid. The invention can be drunk before drinking, during drinking or after drinking, can perform the effects of enhancing the drinking quantity, preventing the body from being injured after drinking, and protecting the liver and the stomach, is safe and effective to take, is beneficial for the health and has the effects of sobering-up, nourishing and health care.