The invention relates to cleaning and sterilizing devices, in particular to an efficient cleaning and sterilizing device for medical supplies. The efficient cleaning and sterilizing device comprises a base plate, a left lateral plate, a cleaning box, a first slide rail, a first slider, a spring, a top plate, a sprayer, a thermal insulation box, a disinfectant box, a disc, a first connecting rod and the like, wherein the left lateral plate is arranged at the left end of the base plate, the first slide rail and a third pulley are arranged on the bottom plate, the third pulley is located on the right of the first slide rail, the first slider is slidably connected to the first slide rail, the spring is connected between the left of the first slider and the inner left of the first slide rail, the cleaning box is connected to the first slider, and a screen plate is arranged in the cleaning box. The efficient cleaning and sterilizing device is thorough in sterilizing, simple to operate and reasonable in design.