The invention relates to a cleaning machine, in particular to a paintbrush cleaning machine. The paintbrush cleaning machine is high in cleaning speed, and brushes of paintbrushes cannot be easily damaged by the paintbrush cleaning machine during cleaning. The paintbrush cleaning machine comprises a bottom plate, vertical plates, a top plate, air cylinders, a frame, a drain pipe, a first valve, anannular slide rail, an annular slider, a disc, an L-shaped draw bar, a spring, an arc-shaped clamp plate and the like. The air cylinders are symmetrically mounted on the left side and the right sideof the top of the bottom plate and are vertically arranged, the frame is mounted between telescopic rods of the air cylinders on the left side and the right side of the top of the bottom plate, the drain pipe is connected with the middle of the bottom of the frame and is communicated with the inside of the frame, and the first valve is arranged on the drain pipe. The paintbrush cleaning machine has the advantages that the upper portions of the paintbrushes can be scrubbed by a scrubbing device, accordingly, the paintbrushes can be thoroughly cleaned by the paintbrush cleaning machine, the paintbrush cleaning machine is high in cleaning speed, and the brushes of the paintbrushes cannot be easily damaged by the paintbrush cleaning machine during cleaning.