Alkaline ionic liquid and its prepn process and application

Abstract

The present invention is one kind of alkaline ionic liquid and its preparation process and application in Pd catalyzed C-C and C-N coupling reaction, and belongs to the field of new material and fine chemical technology. The alkaline ionic liquid consists of two parts, cation A+ and anion B-. The cation A+ precursor is imidazole, pyridine, etc; and the anion B- is alkaline group X- or non-alkaline group Y-. The alkaline ionic liquid is prepared through the first quaternizing with alkyl halide as the quaternizing reagent to obtain ion type halide; and the subsequent ion exchange to obtain the target alkaline ionic liquid. The alkaline ionic liquid of the present invention may act as acid-binding agent and can avoid formation of sticky inorganic salt to facilitate reuse.

Description

technical field [0001] The invention relates to an alkaline ionic liquid and its preparation method, as well as its application in palladium-catalyzed carbon-carbon and carbon-nitrogen coupling reactions, belonging to the field of new materials and fine chemicals. Background technique [0002] The carbon-carbon / carbon-nitrogen coupling reaction under the action of the transition metal palladium compound catalyst plays an important role in organic synthetic chemistry. It is an effective means for preparing many fine chemicals and pharmaceutical intermediates, and can be applied to drugs, pesticides , dyes, daily chemicals and polymers. However, the shortcoming of this reaction has the following aspects: 1. the catalyst system is unstable, and after a fresh catalyst is used once, palladium black is often precipitated—catalyst deactivation; It can be effectively carried out, and the cheap substrates chlorinated aromatic hydrocarbons and brominated aromati...

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Problems solved by technology

However, the shortcoming of this reaction has the following aspects: 1. the catalyst system is unstable, and after a fresh catalyst is used once, palladium black is often precipitated—catalyst deactivation; It can be effectively carried out, and the cheap substrates chlorinated aromatic hydrocarbons and brominated aromatic hydrocarbons are difficult to activate; ③The use of alkali-using organic bases or inorganic bases as acid-binding agents, forming a large number of by-products sodium salts, potassium salts or ammonium salts, these by-products The accumulation of salt will gradually poison and deactivate the transition metal palladium catalyst, which limits the reuse of the catalyst; the by-product solid salt is mixed with the organic product into a paste, which brings difficulties to product separation; Poor solubility in solvents and reactants affects its acid-binding effect, thus limiting the coupling reaction rate and efficiency

④The use of toxic and harmful organic solvents not only pollutes the environment, but also brings cumbersome operations to the separation and purification of subsequent products; ⑤The residues of metal palladium and phosphine ligands in organic products limit the use of products in the fields of medicine and food

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