92results about "Mercapto/sulfide group formation/introduction" patented technology

The invention discloses aryl alkyl thioether compounds and a synthesis method thereof. The synthesis method comprises the steps: in a reaction solvent, with an arylamine derivative and halogenated hydrocarbon as reaction raw materials, and Na2S2O3 as a vulcanization reagent, in the presence of a copper reagent catalyst, and reacting to obtain the aryl alkyl thioether compounds. According to the synthesis method disclosed by the invention, raw materials are easy to obtain and low in price, the reaction operation is simple, the reaction conditions are mild, the yield is higher, the tolerance of a functional group is excellent, later-phase modification of compounds of medicines, sugars, amino acids and the like is successfully realized, and an efficient method for constructing a carbon-sulfur bond is provided for researches of medicinal chemistry and biology orthogonal chemistry.

The present invention provides a method for improved preparation of Sugammadex sodium.

The invention discloses a method for preparing (Z)-1,2-disulfide-1-olefin by the catalysis of metal copper salt, comprising the following steps of: using metal copper salt as a catalyst and using (Z)-1-bromine-2-thioether-1-olefin or mercaptan as a substrate under the action of alkaline in an organic solvent to synthesize (Z)-1,2-disulfide-1-olefin. The invention has the following advantages: the raw materials in the method are easily available; the preparation method is simple; as the catalyst, the metal copper salt is cheap and easily available; (Z)-1,2-disulfide-1-olefin prepared by the method has an extensive application prospect in the fields of coordination chemistry, material science, organic synthesis and the like.

The invention discloses a method for preparing diaryl disulfide and diaryl diselenide under the catalysis of an aqueous phase. A water-soluble catalyst is used for efficiently catalyzing the reaction of sulfur powder or selenium powder with aryl halide in the pure aqueous phase, so the method for preparing disulfide-bond-containing and diselenide-bond-containing aromatic compounds is environmentally-friendly, simple and convenient to operate, safe, low in cost and efficient. Compared with the prior art, the method can be suitable for a large number of functional groups, ensures high yield and few side products, and is simple and convenient to operate, safe, low in cost and environmentally-friendly.

The invention discloses a preparation method of an alpha-trifluoromethylthio substituted acetophenone compound. The preparation method comprises the following steps: by taking aryl ketone as a substrate, sodium trifluoromethanesulfinate as a trifluoromethylthio reagent, triphosgene as an additive, pyridine as a catalyst and dichloroethane as a solvent, in the nitrogen protection mode, stirring for12 hours at the temperature of 60 DEG C, performing a TLC tracking reaction, and conducting column chromatography isolation after sufficiently completing the reaction, thereby obtaining the alpha-trifluoromethylthio substituted acetophenone compound. According to the preparation method, the triphosgene is used as the reaction additive, so that using an expensive trifluoromethylthio reagent is avoided, but so far, a method for introducing trifluomethylthio has not been reported, the preparation method is simple and convenient, is low in cost, and is high in yield, a product is directly obtained, without any transition metal catalysis, and therefore, the preparation method is extremely high in practical popularization value.

Methods for carbon-sulfur (C S) or carbon-oxygen (C-O) coupling reactions are provided. The methods involve the use of a transition metal complex comprising a heterocyclic carbene ligand complexed with a transition metal. Transition metal complexes comprising a heterocyclic carbene ligand complexed with nickel are also provided. The nickel heterocylic carbene complexes may be used for C-S or C-O coupling reactions.

The invention relates to a method for synthesizing benzyl alkyl sulfur ether. With thiourea as a sulfur source, benzyl bromide or benzyl halide reacts with alkyl alkyl halide under the catalysis effect of inorganic alkali to obtain an asymmetric benzyl alkyl sulfur ether compound. The method avoids the use of mercaptan with a pungent smell as the sulfur source, and adopts the one-pot method, so that the purpose of environmental protection can be achieved, and the operational program is simplified to further reduce the cost of synthesis and large-scale production.

The invention relates to a benzyl thioether compound and a preparation method thereof, and belongs to the technical field of organic compounds. The preparation method provided by the invention comprises the following step: in a protective atmosphere, oxalate and a sulfur source react in a solvent under the action of a catalyst, a reducing agent and a ligand to obtain the benzyl thioether compound. According to the preparation process of the benzyl thioether compound, oxalate and a sulfur source are used as raw materials, the raw materials are simple and easy to obtain, the reaction condition is mild and environment-friendly, nickel halide is used as a catalyst in the reaction, the obtained yield is high, and the method can be suitable for amplification reaction and lays a foundation for industrial production.

The present invention provides oxalic amide ligands and uses thereof in copper-catalyzed coupling reaction of aryl halides. Specifically, the present invention provides a use of a compound represented by formula I, wherein definitions of each group are described in the specification. The compound represented by formula I can be used as a ligand in copper-catalyzed coupling reaction of aryl halides for the formation of C—N, C—O and C—S bonds.

The present invention is a method for promoting hydrothiolation of an unactivated alkenes with a thiol using gallium triflate.

The invention discloses a method for performing metal catalytic coupling reaction by utilizing an organic anion-cation pair, and belongs to the field of preparation of a high polymer material. The method for preparing the organic anion-cation pair comprises the following steps of: (a) mixing tetra-alkyl ammonium hydroxide or phosphine hydroxide with acid in water, and after dissolving, obtaining a reaction mixture; (b) stirring the obtained reaction mixture for 8-12 hours under the protection of nitrogen N2, thereby obtaining an ion exchange product; (c) cooling and drying the obtained ion exchange product for 24-48 hours, and after freeze-drying, obtaining a solid ion exchange product; and (d) vacuum-drying the obtained solid ion exchange product for 24-36 hours under the 30-50 DEG C temperature condition, thereby obtaining the organic anion-cation pair. The method for preparing the organic anion-cation pair is simple in process and convenient in preparation; the quaternary ammonium base is low in cost; the cost of base in the coupling reaction is efficiently reduced; the quaternary ammonium cation or quaternary phosphine cation is easy to dissolve in an organic solvent; and the problem that inorganic base is difficult to dissolve in the organic solvent is efficiently solved.

The invention belongs to the field of chemistry, and relates to a synthetic method of asymmetrical thioether. The synthetic method comprises the following steps of (a) under the condition of catalysis of tetrabutyl ammonium halide, enabling a structural compound as shown in a formula (I), a structural compound as shown in a formula (II) and sulfur oxonium salt to react in a solvent so as to obtain the asymmetrical thioether with a structure as shown in formula (III), wherein R1 is selected from phenyl, substituted phenyl, naphtyl, substituted naphtyl, thienyl, or substituted thienyl; R2 is selected from hydrogen, phenyl, substituted phenyl, naphtyl, substituted naphtyl, thienyl or substituted thienyl; or R1, R2 and C connected with R1 and R2 form fluorene or thioxanthene; R3 is selected from hydrogen or an alkyl group; R4 is selected from hydrogen, phenyl, substituted phenyl, naphtyl, substituted naphtyl, thienyl or substituted thienyl; R5 is selected from hydrogen; or R4, R5 and C connected with R4 and R5 form the fluorene or the thioxanthene; R6 is selected form the alkyl group or the substituted alkyl group; and X is selected from C1, Br or I.

The invention discloses a synthetic method of asymmetric thioether. According to the method, alcohol which is cheap, easy to obtain, wide in source, stable and low in toxicity is used as an alkylationreagent, trimethyl halosilane is used as a non-transition metal catalyst, a solvent is not needed, and an asymmetric thioether compound is directly synthesized through a high-selectivity dehydrationSalkylation reaction. According to the method, the use of a transition metal catalyst and alkali is avoided, the catalytic method is simple, the condition is simple, the operation is easy, the byproduct is water, the synthesis efficiency is high, and the selectivity is good.

The invention belongs to the technical field of organic synthesis of sulfur-containing compounds and discloses a thioether compound and a synthetic method and application thereof. The thioether compound is prepared by the following steps: mixing acetone, a disulfide compound, inorganic base and 18-crown ether-6, heating and stirring, reacting under the action of a catalyst of inorganic base in theair atmosphere, concentrating and purifying to prepare the thioether compound. The molecular structural formula of the thioether compound is as shown in the formula (1) in the specification, whereinR1 and R2 are selected from hydrogen atom, alkyl group, alkoxy group, nitro group, amino group, hydroxyl group, halogeno, acyl group, aryl group or heterocyclic group. The use of high-toxicity halohydrocarbon, such as dichloromethane and diiodomethane is avoided by the method. The synthetic method has simple steps, is simple to operate and is feasible, is environmentally-friendly and has high conversion rate under mild conditions. Yield of the product reaches up to 96%. The thioether compound can be applied in the field of preparation of organic synthetic intermediates.

The present relates to a method and a kit to produce an optically pure α-sulfenylated carbonyl compound comprising a primary or a secondary propargylic alcohol and an aryl thiol, a transition metal catalyst and a solvent.

Novel thioalkylcarboxylate-modified CDs and pharmaceutical compositions comprising these thioalkylcarboxylate-modified CDs are disclosed, as well as methods of using the disclosed thioalkylcarboxylate-modified CDs and pharmaceutical compositions thereof to neutralize or reduce undesired effects or symptoms associated with one or more fentanyl related compounds in a subject in need thereof. The use of the disclosed thioalkylcarboxylate-modified CDs to detect the presence of one or more fentanyl related compounds in a sample is also disclosed, which comprises contacting the sample with said thioalkylcarboxylate-modified CDs or a composition comprising these CDs.

The invention provides a vulcanizing agent for a hydrogenation catalyst and a preparation method of the vulcanizing agent. Sulfur content of the vulcanizing agent is 40wt%-80wt%, and the vulcanizing agent contains straight-chain polysulfide and cyclic polysulfide. The preparation method comprises steps as follows: elemental sulfur and a catalyst are weighed proportionally and added to a reactor, the reactor is closed and heated, and then olefins are added to the reactor; pressure in the reactor is increased continuously, when pressure in the reactor reaches a certain value, an air release valve of the reactor is opened, gas in the reaction system is released, pressure in the reactor is kept in a constant-value range, the reaction is performed for a period of time in the reaction state, andafter separation, the vulcanizing agent is obtained. The problems of higher toxicity, high production cost, low safety performance, difficulty in transportation and the like of an existing vulcanizing agent are solved, and the organic polysulfide vulcanizing agent which contains simple components and is high in sulfur content, wide in decomposition temperature range and good in oil solubility isprovided.