Synbiotics of bacillus licheniformis and oligosaccharide class prebiotics and composition and formulation thereof

Abstract

The invention relates to a synbiotics of bacillus licheniformis and oligosaccharide class prebiotics and a composite and a formulation thereof, being characterized in that the synbiotics comprises bacillus licheniformis medical live bacterial powder and the oligosaccharide class prebiotics, wherein the bacillus licheniformis medical live bacterial powder contains live bacteria about 30 billion/gram; the weight ratio of the bacillus licheniformis medical live bacterial powder to the oligosaccharide class prebiotics is 1:1 to 76; the weight ratio of the medical live bacterial powder of the composite, the oligosaccharide class prebiotics and auxiliary materials is as follows: 1.25-5 percent of the bacillus licheniformis medical live bacterial powder, 5-95 percent of the oligosaccharide class prebiotics, 20-50 percent of preferable oligosaccharide class prebiotics, 30-65 percent of diluting agents, 1-20 percent of bonding agents, 1-15 percent of disintegrating agents, 0.1-3 percent of lubricating agents, 1-10 percent of coating agents, 0.01-0.1 percent of flavoring agents, 0.0001-0.001 percent of coloring agents, and 0.1-15 percent of suspending agents. The synbiotics composite is prepared into oral common tablets, oral cavity disintegration tablets, dispersing tablets, enteric-coated tablets, granular formulation, enteric-coated granular formulation, capsules, enteric-coated capsules, dry supensoid agents and external tablets according to a conventional process; and an in vitro test shows that each formulation can promote the growth and the reproduction of the synbiotics of bacillus licheniformis, restrain the growth of harmful bacteria, enhance the immunizing power of parasitifers, reduce diarrhea and enhance the health care.

Description

Technical field [0001] The invention belongs to the field of medical biotechnology and relates to a synbiotic of Bacillus licheniformis and oligosaccharide prebiotics and its composition and preparation. Background technique [0002] With the deepening of microecology, microecological modulators have also developed rapidly. The so-called microecological modulator refers to the adjustment of microecological imbalance, maintenance of microecological balance, and improvement of microecological balance under the guidance of microecological theory. Preparations made of beneficial bacteria and their metabolites and growth-promoting substances that improve human health or enhance health, also known as microbial products. It is a new type of preparations developed after antibiotics that contain beneficial microorganisms and their growth-promoting substances. . Unlike antibiotics, these products do not kill bacteria, but promote bacteria, promoting the growth and development of phys...

AI Technical Summary

Problems solved by technology

Oligosaccharides are an important class of prebiotics. The current research is mainly on probiotics such as bifidobacteria and lactic acid bacteria. They have a highly selective proliferation effect on probiotics, greatly impr

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