Erythromycin micro pill enteric coatel tablet and its preparation method

A technology of erythromycin and enteric-coated tablets, applied in the field of medicine, can solve the problems of destroying gastric acid, affecting digestion, missed or mistaken intake, etc., and achieves the effects of reducing incidence, improving stability, and improving bioavailability

Inactive Publication Date: 2005-03-09
范敏华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This will not only easily lead to missed doses, but also have an impact on the stomach, destroying gastric acid and affecting digestion

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: In this example, 1000 erythromycin pellet-type enteric-coated tablets were prepared, using the following ingredients:

[0016] Erythromycin 125g

[0017] Microcrystalline Cellulose 100g

[0018] Povidone 10g

[0019] Crospovidone 15g

[0020] Low-substituted hydroxypropyl cellulose 10g

[0021] Starch 140g

[0022] Appropriate amount of starch slurry

[0023] Magnesium Stearate 3g

[0024] Fumed silica 3g

[0025] Barrier Coating Prescription

[0026] Hydroxypropyl Methyl Cellulose 8g

[0027] Polyethylene glycol 0.8g

[0028] Propylene glycol 0.8g

[0029] Castor oil 0.8g

[0030] Enteric Coating Prescription

[0031] Enteric acrylic resin 20g

[0032] Phthalates 2g

[0033] Process steps:

[0034] 1. Place the erythromycin and microcrystalline cellulose of the prescribed amount in the fluidized bed; dissolve the povidone of the prescribed amount in an appropriate amount of ethanol as a binder to prepare pellets;

[0035] 2. Mix the prescript...

Embodiment 2

[0038] Embodiment 2: This embodiment prepares 1000 erythromycin pellet type enteric-coated tablets, using the following ingredients:

[0039] Erythromycin 125g

[0040] Calcium hydrogen phosphate 80g

[0041] Hypromellose 10g

[0042] Sodium carboxymethyl starch 20g

[0043] Dextrin 70g

[0044] Mannitol 80g

[0045] Gelatin 10g

[0046] Polyethylene glycol 3g

[0047] Talc powder 3g

[0048] Barrier Coating Prescription

[0049] Povidone 8g

[0050] Enteric Coating Prescription

[0051] Shellac 15g

[0052] Triacetin 2g

[0053] Process steps:

[0054] 1. Mix the prescribed amount of erythromycin and calcium hydrogen phosphate, and dissolve the prescribed amount of hypromellose in an appropriate amount of ethanol aqueous solution as a binder; prepare pellets by extrusion spheronizer;

[0055] 2. Mix the prescribed amount of sodium carboxymethyl starch, dextrin, and mannitol, granulate with gelatin pulp, dry, and granulate, and mix the granulated granules with the...

Embodiment 3

[0058] Embodiment 3: This embodiment prepares 1000 erythromycin pellet type enteric-coated tablets, using the following ingredients:

[0059] Erythromycin 125g

[0060] Sucrose type blank core 60g

[0061] Lactose 50g

[0062] Povidone 10g

[0063] Croscarmellose Sodium 32g

[0064] Modified starch 20g

[0065] Starch 80g

[0066] Sucrose 40g

[0067] Appropriate amount of starch slurry

[0068] Sodium Lauryl Sulfate 1g

[0069] Hydrogenated vegetable oil 1g

[0070] Fumed silica 3g

[0071] Barrier Coating Prescription

[0072] Hydroxypropyl Cellulose 8g

[0073] Polyethylene glycol 0.8g

[0074] Enteric Coating Prescription

[0075] Hydroxypropyl Methylcellulose Phthalate 20g

[0076] Acetyl monoglyceride 2g

[0077] Process steps:

[0078] 1. Suspend or dissolve the prescribed amount of povidone, erythromycin and lactose in an appropriate amount of ethanol aqueous solution, place the prescribed amount of sucrose-type blank cores in a fluidized bed; side spra...

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PUM

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Abstract

A micropill-type enteric tablet of erythromycin is proportionally prepared from erythromycin, filler, adhesive, lubricant, flowing aid, isolating coating and enteric coating.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an erythromycin pellet type enteric-coated tablet and a preparation method thereof. Background technique [0002] Erythromycin is a macrolide antibiotic with a similar antibacterial spectrum to penicillin. Has a strong antibacterial effect. It has a certain effect on Gram-negative bacteria such as meningococcus, Neisseria gonorrhoeae, pertussis bacillus, influenza bacillus, Brucella, some Shigella and Escherichia coli. Strains resistant to penicillin are generally sensitive to erythromycin. The antibacterial mechanism of erythromycin is mainly combined with the 50S subunit of the ribonucleosome, inhibiting the peptide acyl transferase, affecting the translocation process of the ribonucleosome, hindering the growth of the peptide chain, inhibiting the synthesis of bacterial proteins, and inhibiting the synthesis of bacterial proteins. Bacteria. [0003] Erythr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K9/20A61K31/7048A61P31/04
Inventor 范敏华
Owner 范敏华
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