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Erythromycin enteric-coated capsule and preparation thereof

An enteric-coated capsule and erythromycin technology, which is used in capsule delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problem that unsaturated groups are easily released, affect product quality and efficacy, and cannot guarantee product qualifications. and other problems to achieve the effect of ensuring quality and curative effect, good product quality and high work efficiency

Active Publication Date: 2008-08-13
TIANSHENG PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the release rate of erythromycin enteric-coated capsules currently on the market is unstable, and the release rate gradually decreases during storage, so that the product cannot be guaranteed to be qualified within the validity period, which seriously affects the quality and curative effect of the product
Tracing it to its cause is mainly because the main component cellulose acetate phthalate in the enteric-coating liquid proportioning of the enteric-coated micropill contained in the existing erythromycin enteric-coated capsule contains unsaturated ester bond and hydrocarbon group, in storage During the process, unsaturated groups are easy to dissociate, resulting in reduced release

Method used

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  • Erythromycin enteric-coated capsule and preparation thereof
  • Erythromycin enteric-coated capsule and preparation thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0024] An erythromycin enteric-coated capsule, wherein the proportion of the enteric-coating liquid components of the enteric-coated pellets is calculated by weight: polyacrylic acid resin II: 1, diethyl phthalate: 0.07, Tween-80 : 0.08, castor oil: 0.08, ethanol with a concentration greater than or equal to 95%: 12.

[0025] Its preparation method is as follows:

[0026] a. Dissolve the polyacrylic acid resin II in the ethanol of the above ratio according to the above-mentioned enteric coating liquid composition ratio, and then add the remaining components in the ratio, stir evenly and dissolve to obtain the enteric coating liquid spare;

[0027] b. mixing the erythromycin raw material containing a therapeutically effective amount with sucrose to make erythromycin pellets with a particle size of 0.6 to 0.8 mm for subsequent use;

[0028] c. Enteric-coating the above-mentioned erythromycin pellets: placing the above-mentioned erythromycin pellets in a BZJ-1000F II type coati...

Embodiment 2

[0031] The composition ratio of the enteric coating solution of the enteric-coated pellets is shown in Table 3.

[0032] In the preparation method: in step c, the rotating speed of the coating granulator is 40 rpm, the rotating speed of the spray gun power gear pump is 30 rpm, and 3 blowing devices are added above the coating granulator, and the obtained product is detected in step d. The enteric coating weight gain rate of erythromycin enteric-coated pellets was 12%.

[0033] All the other are with embodiment 1.

Embodiment 3

[0035] The composition ratio of the enteric coating solution of the enteric-coated pellets is shown in Table 3:

[0036] In its preparation method: in step c, the rotating speed of the coating granulator is 60 rpm, the rotating speed of the spray gun power gear pump is 40 rpm, and 2 blowing devices are added around the coating granulator, and the obtained product is detected in step d. The enteric coating weight gain rate of erythromycin enteric-coated pellets was 18%.

[0037] All the other are with embodiment 1.

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Abstract

The invention provides an erythromycin enteric-coated capsule and the preparation method. The invention is characterized in that: the component ratio of the enteric-coated liquid of the enteric-pellets capsules contained in the enteric-coated capsules counted by weight percentage is that: polyacrylic resin: II: 1, diethyl phthalate: 0.07 to 0.1, Tween-80:0.08 to 0.12, castor oil: 0.08 to 0.12, ethanol whose concentration is bigger than or equal to 95%: 12 to 14; all are counted as weight percentage. The invention conquers defects in the prior art, elevates the product quality, keeps the releasing degree of the product stable and guarantees the quality as well as healing effect of the product during the period of validity, and also the preparation is simple and convenient, the work efficiency is high and the quality of the products is quite well.

Description

technical field [0001] The invention relates to an erythromycin enteric-coated capsule and a preparation method thereof. Background technique [0002] Erythromycin enteric-coated capsules belong to antibiotic drugs, and the main indications are 1. As an alternative drug for penicillin-allergic patients to treat hemolytic streptococcus, Streptococcus pneumoniae and other infections; 2. Legionnaires’ disease; 3. Mycoplasma pneumoniae pneumonia; 4. Pneumonia Chlamydia pneumonia; 5. Other genitourinary infection caused by Chlamydia and Mycoplasma, Chlamydia trachomatis conjunctivitis, gonococcal infection, oral infection caused by anaerobic bacteria, Campylobacter jejuni enteritis, whooping cough, etc. Because erythromycin is very irritating to the stomach, the content of the existing erythromycin capsules adopts enteric-coated pellets, that is, enteric-coated pellets are coated on the pellets to prevent the release of erythromycin in the stomach, so that it is only The therape...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K9/58A61K31/7048A61P31/04
Inventor 黄云川
Owner TIANSHENG PHARMA GROUP
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