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Detachable T-shaped microchannel device and method for preparing monodisperse polymer microspheres by same

A technology of microchannels and polymers, applied in chemical instruments and methods, pharmaceutical formulations, chemical/physical processes, etc., to achieve the effects of easy dredging, simple equipment, and narrow particle size distribution

Inactive Publication Date: 2011-10-12
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, it has been reported abroad that the fiber of PLGA has been prepared by the microchannel method, but the microspheres of polylactic acid and its copolymers have not been reported by the microchannel device.

Method used

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  • Detachable T-shaped microchannel device and method for preparing monodisperse polymer microspheres by same
  • Detachable T-shaped microchannel device and method for preparing monodisperse polymer microspheres by same
  • Detachable T-shaped microchannel device and method for preparing monodisperse polymer microspheres by same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1: Preparation of polylactic-co-glycolic acid (PLGA) microparticles

[0031] A T-shaped microchannel with a diameter of 129 μm at the needle tip of the dispersed phase and a 300 μm equivalent diameter of the continuous phase at the T-shaped nozzle is processed. A certain mass of polylactic acid-glycolic acid copolymer (molecular weight 15,000) was weighed and dissolved in dichloromethane to obtain a dispersed phase with a concentration of 1% g / ml. Weigh a certain mass of polyvinyl alcohol-124 and dissolve it in water to obtain a continuous phase with a concentration of 0.5% g / ml. Turn on the peristaltic pump in the constant flow device and adjust the flow rate to 20ml / min. Draw 10ml of the dispersed phase with a syringe, install the syringe into a syringe pump, and adjust the flow rate of the dispersed phase to 0.2ml / min. After the dispersed phase is injected into the T-shaped nozzle, open the water stop clamp, the continuous phase fluid enters the T-shaped pi...

Embodiment 2

[0032] Example 2: Preparation of polylactic-co-glycolic acid (PLGA) microparticles

[0033] A T-shaped microchannel with a diameter of 129 μm at the needle tip of the dispersed phase and a 300 μm equivalent diameter of the continuous phase at the T-shaped nozzle is processed. A certain mass of polylactic acid-glycolic acid copolymer (molecular weight 15,000) was weighed and dissolved in dichloromethane to obtain a dispersed phase with a concentration of 1% g / ml. Weigh a certain mass of polyvinyl alcohol-124 and dissolve it in water to obtain a continuous phase with a concentration of 1% g / ml. Turn on the peristaltic pump in the constant flow device and adjust the flow rate to 20ml / min. Draw 10ml of the dispersed phase with a syringe, install the syringe into a syringe pump, and adjust the flow rate of the dispersed phase to 0.03 ml / min. After the dispersed phase is injected into the T-shaped nozzle, open the water stop clamp, the continuous phase fluid enters the T-shaped pipe...

Embodiment 3

[0034] Example 3: Preparation of polylactic-co-glycolic acid (PLGA) microparticles

[0035] A T-shaped microchannel with a diameter of 129 μm at the needle tip of the dispersed phase and a 300 μm equivalent diameter of the continuous phase at the T-shaped nozzle is processed. A certain mass of polylactic acid-glycolic acid copolymer (molecular weight 15,000) was weighed and dissolved in dichloromethane to obtain a dispersed phase with a concentration of 1% g / ml. Weigh a certain mass of polyvinyl alcohol-124 and dissolve it in water to obtain a continuous phase with a concentration of 1% g / ml. Turn on the peristaltic pump in the constant flow device and adjust the flow rate to 20ml / min. Draw 10ml of the dispersed phase with a syringe, install the syringe into a syringe pump, and adjust the flow rate of the dispersed phase to 0.4ml / min. After the dispersed phase is injected into the T-shaped nozzle, open the water stop clamp, the continuous phase fluid enters the T-shaped pipe...

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Abstract

The invention discloses a detachable T-shaped microchannel device and a method for preparing monodisperse polymer microspheres by the same. The method comprises the following steps of: performing heat treatment on a needle tube serving as a disperse phase flowing channel, and processing a duct with the same outer diameter as the needle tube on a pipeline serving as a continuous phase flowing channel to make the disperse phase needle tube and the continuous phase tube form a T-shaped channel; under the stable operating condition, making dispersed fluid form uniform micro liquid drops at a T-shaped tube orifice through the shearing force of continuous phase fluid to the disperse phase fluid; and under the action of a shaker, diffusing an organic solvent out of the liquid drops, and curing the liquid drops to form the polymer microspheres with uniform particle size. The T-shaped microchannel device is simple in equipment and can be detached, and pipelines are easy to dredge after being blocked; and the prepared polymer microspheres have uniform particle size, the particle size distribution coefficient of less than 15 percent, the minimum particle size distribution coefficient of 3 percent, and smooth surfaces without adhesion.

Description

technical field [0001] The invention relates to a detachable T-shaped microchannel device and a method for preparing monodisperse polymer microspheres. The prepared polymer microspheres are mainly used in the pharmaceutical slow-release preparation industry. Background technique [0002] As a sustained and controlled release drug carrier, monodisperse biodegradable polymer microspheres can not only improve bioavailability, but also play an irreplaceable role in the sustained and controlled drug release system. Because in a drug sustained-release system, if the drug-loaded microspheres used are all loaded with the same dose of drug, then this system can achieve the best control over the drug dose. In addition, as a functional polymer material, polymer microspheres with uniform micron-sized particles are also widely used in analytical chemistry, biochemistry, immunomedicine, standard metrology and some high-tech fields. [0003] The preparation methods of monodisperse polymer...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J19/00C08J3/16A61K47/30A61K47/34
Inventor 关怡新缪世锋余金鹏姚善泾
Owner ZHEJIANG UNIV
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