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Bilobalide K dropping pill and preparation method thereof

A technology of ginkgolide and dripping pills, which is applied in the directions of pill delivery, pharmaceutical formulations, and medical preparations of inactive ingredients, etc., can solve the problems of slow dissolution rate of ginkgolide K and small dosage of drugs, etc.

Inactive Publication Date: 2018-03-06
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention makes ginkgolide K into dripping pills, which solves the problems of slow ginkgolide K dissolution rate and small dosage, and can improve oral bioavailability and drug compliance of patients

Method used

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  • Bilobalide K dropping pill and preparation method thereof
  • Bilobalide K dropping pill and preparation method thereof
  • Bilobalide K dropping pill and preparation method thereof

Examples

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preparation example Construction

[0028] The present invention also provides the preparation method of described ginkgolide K dropping pills, comprising the steps of:

[0029] (1) Preparation of matrix: take polyethylene glycol 4000 or polyethylene glycol 6000, 5-15% poloxamer or polysorbate 80 accounting for 70-87.5% of the total weight of ginkgolide K dripping pills, mix homogeneous, molten, to obtain a molten matrix;

[0030] (2) prepare the mixed solution of medicine and matrix: 7.5~15% ginkgolide K powders that account for the ginkgolide K dripping pill gross weight are mixed with the molten matrix described in step (1), obtain the mixed medicinal solution of melting;

[0031] (3) Preparation of dripping pills: adjust the temperature of the dripping pill machine and drop the molten mixed medicinal solution obtained in step (2) into the condensing agent drop by drop under the condition of heat preservation of 80-100°C. Take out the shrinkage-molded dropping pills at the outlet, remove the condensate, and ...

Embodiment 1

[0037] (1) Preparation of matrix: take 37.5g of polyethylene glycol 4000 and 5.0g of poloxamer, mix them evenly, place them in a water bath with a magnetic stirrer at 95°C and heat and stir until all the above components are melted to obtain a molten matrix ;

[0038] (2) Prepare the mixed solution of medicine and substrate: 7.5g of ginkgolide K powder is added in the molten substrate obtained in step (1), and mixed uniformly to obtain a molten mixed medicinal solution;

[0039] (3) Preparation of dripping pills: put the molten mixed medicinal solution obtained in step (2) in a dripping pill machine, and drop it dropwise into the condensing agent under the condition of heat preservation at 90°C. The inner diameter of the dripper is 3mm, and the condensing agent It is liquid paraffin, and the cooling temperature is 5°C. After the cooling is complete, take out the shrinkage-molded dropping pills from the outlet of the dropping pill machine, remove the condensate, and dry to obta...

Embodiment 2

[0041] (1) Preparation of matrix: take 37.5 g of polyethylene glycol 6000 and 5.0 g of polysorbate 80, mix them uniformly, place them in a water bath with a magnetic stirrer at 95°C, heat and stir until all the above components are melted, and obtain a molten matrix;

[0042] (2) Prepare the mixed solution of medicine and substrate: 7.5g of ginkgolide K powder is added in the molten substrate obtained in step (1), and mixed uniformly to obtain a molten mixed medicinal solution;

[0043] (3) Preparation of dripping pills: put the molten mixed medicinal solution obtained in step (2) in a dripping pill machine, and drop it into the condensing agent drop by drop under the condition of heat preservation of 100°C. The inner diameter of the dripper is 3mm, and the condensing agent Dimethicone 50, the cooling temperature is 10°C, after the cooling is complete, take out the shrinkage-molded dropping pills from the outlet of the dropping pill machine, remove the condensate, and dry to ob...

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Abstract

The invention relates to the field of medicine preparations and in particular to a bilobalide K dropping pill and a preparation method thereof. The bilobalide K dropping pill consists of the followingcomponents in parts by mass: 7.5-15.0 parts of bilobalide K, 70-87.5 parts of a water-soluble substrate and 5-15 parts of a solubilizer. The invention further discloses a preparation method of the bilobalide K dropping pill. As the bilobalide K is prepared into the bilobalide K dropping pill, the dissolution rate of the bilobalide K is increased, the bioavailability of oral taking is improved, and the bilobalide K dropping pill has the characteristics of being small in dosage, high in product stability, good in medicinal compliance of patients, and the like.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a ginkgolide K dropping pill and a preparation method thereof. Background technique [0002] Ginkgolide is an effective substance extracted from the leaves of the Chinese herbal medicine Ginkgo biloba. This substance can be further subdivided into ginkgolides A, B, C, bilobalide, etc. from the structure. For ginkgolides, Chinese patent document CN1313287A discloses A production process of ginkgolide was developed. The method for separating ginkgolide monomers from the total extract of ginkgolides also has many relevant bibliographical reports. For example, people such as You Song introduced the separation and structure determination method of ginkgolides in Ginkgo biloba (see You Song et al. , Separation and structure determination of ginkgolides in Ginkgo biloba leaves, Chinese Journal of Medicinal Chemistry, No. 4, 1995). The Ginkgolide K described in the invention ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/365A61K47/10A61K47/26A61P9/10A61P25/00
CPCA61K9/2018A61K9/2031A61K31/365
Inventor 萧伟刘文君陈益航孟兆青胡玉梅程宁波杨彪房卉黄文哲王振中
Owner JIANGSU KANION PHARMA CO LTD
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