Chewing tablet of proton pump inhibitor

A proton pump inhibitor and chewable tablet technology, applied in the field of proton pump inhibitor chewable tablets, can solve the problems of delayed acid suppression effect of proton pump inhibitor, unfavorable timely treatment and rapid relief of pain, etc., to reduce manpower and improve medication compliance. properties, reducing the effect of the coating process

Inactive Publication Date: 2007-11-07
JIANGSU AOSAIKANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Since proton pump inhibitors are easily degraded in an acidic environment, the usual oral preparations of proton pump inhibitors adopt enteric coating to prevent the active ingredient from degrading in gastric acid. The acid-suppressing effect of proton pump inhibitors is delayed, which is not conducive to timely treatment and rapid relief of patient suffering

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Omeprazole 20g

[0020] Sodium bicarbonate 600g

[0021] Magnesium hydroxide 500g

[0022] Mannitol 200g

[0023] Sorbitol 160g

[0024] Strawberry essence 10g

[0025] Magnesium Stearate 10g

[0026] The above-mentioned amount of omeprazole is mixed with sodium bicarbonate, magnesium hydroxide, mannitol, sorbitol, and strawberry essence through an 80-mesh sieve by the equal-volume incremental method, rolled into large pieces, and granulated through a 18-mesh sieve. Add magnesium stearate, mix evenly, measure the content of the intermediate, and press into tablets to obtain omeprazole chewable tablets.

Embodiment 2

[0028] Omeprazole 40g

[0029] Sodium bicarbonate 600g

[0030] Magnesium hydroxide 500g

[0031] Mannitol 200g

[0032] Sorbitol 160g

[0033] Strawberry essence 10g

[0034] Magnesium Stearate 10g

[0035] The above-mentioned amount of omeprazole is mixed with sodium bicarbonate, magnesium hydroxide, mannitol, sorbitol, and strawberry essence through an 80-mesh sieve by the equal-volume incremental method, rolled into large pieces, and granulated through a 18-mesh sieve. Add magnesium stearate, mix evenly, measure the content of the intermediate, and press into tablets to obtain omeprazole chewable tablets.

Embodiment 3

[0037] Omeprazole Sodium 42.6g

[0038] Sodium bicarbonate 600g

[0039] Magnesium hydroxide 500g

[0040] Mannitol 200g

[0041] Sorbitol 160g

[0042] Strawberry essence 10g

[0043] Magnesium Stearate 10g

[0044] Mix the above-mentioned amount of omeprazole sodium with sodium bicarbonate, magnesium hydroxide, mannitol, sorbitol, and strawberry essence through an 80-mesh sieve according to the equal-volume incremental method, and make large tablets by rolling method, and pass through a 18-mesh sieve to granulate , adding magnesium stearate, mixing evenly, measuring the content of the intermediate, and pressing into tablets to obtain omeprazole sodium chewable tablets.

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PUM

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Abstract

The present invention relates to one kind of chewing tablet of proton pump inhibitor for treating gastric ulcer, duodenal ulcer, stomal ulcer and other indications. The chewing tablet contains proton pump inhibitor in 1-5 wt%, carbonate in 35-60 wt% and hydroxide in 35-60 wt%. The proton pump inhibitor is one selected from omeprazole, S-omeprazole, pantoprazole, lansoprazole, rabeprazole, leminoprazole, tenatoprazole and their salts. The biologically acceptable buffering agent is selected from sodium bicarbonate, sodium carbonate, magnesium carbonate, calcium carbonate and their mixture, preferably sodium bicarbonate. The hydroxide is selected from magnesium hydroxide, calcium hydroxide, aluminum hydroxide, sodium hydroxide and their mixture, preferably magnesium hydroxide.

Description

technical field [0001] A proton pump inhibitor chewable tablet of the present invention relates to a chewable tablet containing at least one proton pump inhibitor, at least one carbonate, and at least one hydroxide, used for treating gastric ulcer, twelve Indications for duodenal ulcer, anastomotic ulcer, reflux, esophagitis, Zoller-Ellison syndrome, etc. Background technique [0002] Digestive system disease is one of common frequently-occurring diseases, and wherein ulcer disease is the most common, and its total sickness rate accounts for 10~12% of total population approximately, and main onset age is 30~50 years old. There are 400,000 people in the United States suffering from peptic ulcers every year, mainly due to smoking, drinking, emotional stress, and drug stimulation (such as ASP, indomethacin, and peptic ulcer). The incidence rate of American men is 10%, and that of women is 5%. %. The gastrointestinal incidence rate is 5-10% in Japan and 12.3% in Germany. Acco...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/10A61K33/08A61K33/00A61K45/06A61K9/20A61K47/02A61P1/04A61K31/4439A61K31/4184A61K31/444
Inventor 叶东李晓昕戴艳
Owner JIANGSU AOSAIKANG PHARMA CO LTD
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