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Rheumatism soft capsule and its preparation method

A technology of soft capsules and Fengtongning, which is applied in the field of Fengtongning soft capsules and its preparation, can solve the problems of no sinomenine hydrochloride, etc., and achieve the effects of easy taking and carrying, high bioavailability, and fast dissolution

Active Publication Date: 2005-12-28
朱慧秋 +1
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AI Technical Summary

Problems solved by technology

But so far, there is no soft capsule of sinomenine hydrochloride

Method used

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Embodiment Construction

[0013] In this embodiment, the pharmaceutical adjuvant is one or more of diluent, latent solvent, suspending agent and antioxidant. In specific implementation, pharmaceutical excipients and preservatives can have the following options:

[0014] Described diluent is one or more in polyethylene glycols, vegetable oil, mineral oil;

[0015] Described latent solvent is propylene glycols;

[0016] The suspending agent is ethyl hydroxyethyl cellulose, chitin, chitosan, methyl cellulose, ethyl cellulose, agar, tragacanth gum, hydroxyethyl methyl cellulose, hydroxyethyl cellulose, hydroxyl One or more of propyl methylcellulose, hydroxypropyl cellulose, beeswax, polyethylene glycol-4000, polyethylene glycol-6000, etc.;

[0017] The antioxidant is sodium bisulfite, sodium pyrosulfite, potassium pyrosulfite, ethylenediaminetetraacetic acid, ethylenediaminetetraacetic acid sodium salt, succinic acid, citric acid, hydroquinone, malic acid, ascorbic acid, sodium ascorbate , inositol, α-t...

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Abstract

A Fengtongning soft capsule and a preparation method thereof. The soft capsule is composed of a medicinal liquid and a capsule shell, and is characterized in that the medicinal liquid contains sinomenine hydrochloride as an active ingredient and a pharmaceutical excipient, and the content of sinomenine hydrochloride is 0.005-0.040 g / grain; the gelatin, glycerin, water and preservative for preparing the capsule shell are prepared in the proportions of 10 parts by weight of gelatin, 3.2-3.6 parts of glycerin, 9.0 parts of water and an appropriate amount of preservative. Soft capsules are molded by compression molding. Compared with the existing formulations of "Fengtongning Injection" and "Fengtongning Tablets", Fengtongning Soft Capsules of the present invention have beneficial effects in that they are stable in quality, convenient to carry and administer; effect.

Description

Technical field: [0001] The invention relates to soft capsule oral medicine containing effective dosage of sinomenine hydrochloride and its preparation. Background technique: [0002] Sinomenine hydrochloride is the hydrochloride salt of the main active ingredient of the traditional Chinese medicine Qingfengteng. The chemical structure of sinomenine is similar to that of morphine, but it does not have the addictive properties of morphine, and has good analgesic and anti-inflammatory effects. Qingfengteng, Li Shizhen recorded in "Compendium of Materia Medica" that it can "cure rheumatism flow injection, experience joints of crane knees, damage and swelling." Make great achievements." "Materia Medica Biandu" says: "This thing is good at curing wind diseases, so all calendar paralysis can be cured." "Pharmacopoeia of the People's Republic of China" summarizes its effects as "dispelling rheumatism, dredging meridians, and diuresis". [0003] Rheumatism is a class of commonly...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K31/4748A61P19/06
Inventor 朱慧秋杨思林
Owner 朱慧秋
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