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A soft capsule of 'Xiao Chai Hu' and method for preparing same

A soft capsule preparation and soft capsule technology, which is applied in the field of preparation of Xiaochaihu soft capsules, can solve the problems of increased pinellia volume, difficulty in guaranteeing curative effect, large difference, etc., and achieves the effect of being easy to take and carry

Inactive Publication Date: 2006-12-20
BEIJING HONGWAN PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The prescription of Xiaochaihu Tangwan is 240 parts by weight of Bupleurum, 120 parts by weight of Scutellaria baicalensis, 120 parts by weight of Pinellia (made from ginger), 120 parts by weight of Codonopsis pilosula, 64 parts by weight of ginger, 80 parts by weight of licorice, and 120 parts by weight of jujube. It can be seen that the ratio of prescription medicinal materials is quite different from the original text of "Treatise on Febrile Diseases", and the preparation process is rough. This dosage form is not conducive to rapid drug absorption, and the drug absorption speed is very different from the original decoction.
[0005] Xiaochaihu Decoction Concentrated Pills and Xiaochaihu Decoction Dripping Pills have the same problem as Xiaochaihu Decoction Pills. The ratio of prescriptions is quite different from the original text of "Treatise on Febrile Diseases". Supported by research reports, and the daily dose of crude drug after conversion of the two-dose prescription is significantly less than Xiaochaihu tablets and granules, so the curative effect is difficult to guarantee
[0006] Compared with the present invention, the prescription ratio of Xiaochaihu Tablets differs in that the amount of Pinellia increases. As a medicinal material with certain toxicity, it should be as little as possible in the medicine for long-term use. The process of extracting and directly crushing into medicine makes quality control difficult, and the absorption rate of active ingredients is slow, which is not as good as the original decoction
[0007] Xiaochaihu granules are the closest to the original decoction in terms of prescription and technology, but they need to be taken with boiling water when used, and the medicinal taste is strong, which is extremely inconvenient for patients to use.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] a. Take the following medicinal materials according to the prescription

[0024] 240 parts by weight of Bupleurum, 90 parts by weight of Scutellaria baicalensis, 90 parts by weight of Pinellia (made from ginger), 90 parts by weight of Codonopsis pilosula, 90 parts by weight of ginger, 90 parts by weight of licorice, and 90 parts by weight of Chinese jujube.

[0025] b. Take Bupleurum, Scutellaria, Codonopsis, Glycyrrhiza and Jujube and add 6 times the amount of water to decoct twice, each time for 1.5 hours, combine the decoction, filter, and concentrate the filtrate to an appropriate amount to obtain a concentrate, which is set aside.

[0026] c. get pinellia (ginger), ginger according to the percolation method (Appendix 10 of the 2005 edition of the Pharmacopoeia) under the item of extract and extract, use 70% ethanol as solvent, after soaking for 24 hours, use 1-3ml per minute Slowly percolate at a high speed, collect about 910 parts by weight of the filtrate, recove...

Embodiment 2

[0030] a. Take the following medicinal materials according to the prescription

[0031] 240 parts by weight of Bupleurum, 90 parts by weight of Scutellaria baicalensis, 90 parts by weight of Pinellia (made from ginger), 90 parts by weight of Codonopsis pilosula, 90 parts by weight of ginger, 90 parts by weight of licorice, and 90 parts by weight of Chinese jujube.

[0032] b. Take bupleurum, scutellaria, codonopsis, licorice and jujube and add 8 times the amount of water to decoct twice, each time for 1.5 hours, combine the decoctions, filter, concentrate the filtrate to an appropriate amount to obtain a concentrate, and set aside.

[0033] c. get pinellia (ginger), ginger according to the percolation method (Appendix 10 of the 2005 edition of the Pharmacopoeia) under the item of extract and extract, use 70% ethanol as solvent, after soaking for 24 hours, use 1-3ml per minute Slowly percolate at a high speed, collect 910 parts by weight of the filtrate, recover ethanol, and ob...

Embodiment 3

[0037] a. Take the following medicinal materials according to the prescription

[0038] 240 parts by weight of Bupleurum, 90 parts by weight of Scutellaria baicalensis, 90 parts by weight of Pinellia (made from ginger), 90 parts by weight of Codonopsis pilosula, 90 parts by weight of ginger, 90 parts by weight of licorice, and 90 parts by weight of Chinese jujube.

[0039] b. Take Bupleurum, Scutellaria, Codonopsis, Glycyrrhiza and Jujube and add 6 times the amount of water to decoct twice, each time for 1.5 hours, combine the decoction, filter, and concentrate the filtrate to an appropriate amount to obtain a concentrate, which is set aside.

[0040] c. get pinellia (ginger), ginger according to the percolation method (Appendix 10 of the 2005 edition of the Pharmacopoeia) under the item of extract and extract, use 70% ethanol as solvent, after soaking for 24 hours, use 1-3ml per minute Slowly percolate at a high speed, collect 920 parts by weight of the filtrate, recover etha...

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PUM

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Abstract

The invention relates to soft capsule preparation and process for preparing same, wherein the preparation is made from Bupleurum root, baikal skullcap root, pinellia tuber, pilose asiabell root, fresh ginger, licorice root and Chinese date through steps of raw material displacement, water extraction, making mixture and encapsulation into soft capsule shells.

Description

technical field [0001] The invention belongs to the technical field of preparation of traditional Chinese medicine preparations, in particular to the preparation of Xiaobupleurum soft capsules. Background technique [0002] The prescription of Xiaochaihu Soft Capsules comes from Xiaochaihu Decoction in Zhang Zhongjing's "Treatise on Febrile Diseases". Twelve pieces (broken)", Xiao Chaihu Decoction in the original book is the main prescription for the treatment of typhoid fever and Shaoyang syndrome. Vomiting. Or chest troubles but not vomiting, or thirst, or abdominal pain, or abdominal pain, or abdominal pain, or palpitations, difficulty urinating, or not thirsty, body fever, or cough, Xiao Chai Hu Decoction. "However, after long-term medical practice, this prescription has been widely used in the treatment of liver and gallbladder, digestion, endocrine, blood, immune and other system diseases. [0003] Although modern research on Xiao Chaihu Tang has made a lot of progre...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/48A61P1/16A61P7/00A61P37/02
Inventor 谭皕营
Owner BEIJING HONGWAN PHARMA TECH
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