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Medicine for treating chronic renal failure and preparation method thereof

A kidney function and drug technology, which is applied in the field of drug preparation, can solve the problems of shortened survival period of patients and high cost of long-term dialysis, and achieve the effects of increasing drug compliance, reducing fibrosis, and reducing dosage

Active Publication Date: 2012-07-04
AIR FORCE MEDICAL CENT PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] As mentioned above, dialysis treatment cannot reverse the damage of nephrons, and many patients cannot bear the high cost of long-term dialysis, which ultimately shortens the survival period of patients

Method used

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  • Medicine for treating chronic renal failure and preparation method thereof

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Experimental program
Comparison scheme
Effect test

no. 1 approach

[0031] Granules 1-1

[0032] Raw materials: raw land 240g, cornus 80g, poria cocos 80g, astragalus 400g, atractylodes macrocephala 80g

[0033] Preparation method: soak 8 times the weight of raw material drug in distilled water for 2 hours, decoct for 1.5 hours, separate to obtain a decoction; add 5 times the weight of raw material drug for decoction for 1 hour, and combine the obtained decoction; third time Add water 5 times the weight of the raw material drug and decoct for 1 hour, combine the obtained decoction, filter the decoction, and concentrate under reduced pressure to a clear paste with a relative density of 1.10. 0.75 times of pharmaceutical excipients were used as base material, and spray-dried to obtain granules. In the spray drying, the inlet air temperature is 75° C., the material temperature is 70° C., and the drying is performed for 1 hour.

no. 2 approach

[0035] Granules 1-2

[0036] Raw materials: raw land 240g, cornus 80g, poria cocos 80g, astragalus 400g, atractylodes macrocephala 80g, angelica 80g, chuanxiong 160g, salvia miltiorrhiza 240g

[0037] Preparation method: same as the first embodiment.

no. 3 approach

[0039] Granules 1-3

[0040] Raw materials: Rehmannia 240g, Cornus 80g, Poria 80g, Astragalus 400g, Angelica 80g, Salvia miltiorrhiza 240g, Chuanxiong 160g, Dilong 120g, Honeysuckle 160g, Atractylodes macrocephala 80g, Rhubarb 80g

[0041] Preparation method: same as the first embodiment.

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Abstract

The invention discloses a medicine for treating chronic renal failure and a preparation method thereof. The medicine for treating chronic renal failure comprises bulk pharmaceutical chemicals, namely rehmanniae praeparatum, fructus corni, Indian buead, astragali radix and rhizoma atractylodis macrocephalae which are proportionally processed and prepared into granules. The medicine for treating chronic renal failure provided by the invention has functions of replenishing qi, nourishing kidney, invigorating spleen, resolving stasis, detoxing and removing turbidity, and can be used for treating the diseases such as early-stage and middle-stage chronic renal failure, spleen and kidney deficiency of syndrome differentiation of chronic kidney disease, blood stasis and obstruction, toxin and turbidity accumulation and the like.

Description

technical field [0001] The invention relates to a medicine for treating chronic renal failure by nourishing the kidney and invigorating the spleen, nourishing blood and removing blood stasis, detoxifying and reducing turbidity, and also relates to a preparation method of the medicine. Background technique [0002] Chronic renal failure (chronic renal failure for short), also known as chronic renal insufficiency, refers to chronic progressive renal parenchymal damage caused by various reasons, resulting in obvious atrophy of the kidneys, unable to maintain their basic functions, clinically manifested as retention of metabolites, water , electrolyte, acid-base balance disorders, the involvement of various systems of the body as the main clinical syndrome. According to relevant statistics, among every million population, 100-150 people suffer from chronic renal failure every year. In terms of treatment, modern medicine has always lacked effective drugs for the treatment of chr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61P13/12A61K35/64A61K35/62
Inventor 张福成吴燕林敏
Owner AIR FORCE MEDICAL CENT PLA
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