Hypromellose enteric empty capsule gelated by gellan gum and potassium chloride

Abstract

A hypromellose enteric empty capsule gelated by gellan gum and potassium chloride belongs to technical field of empty capsule production, is characterized in that hypromellose is used as a main raw material and mixed with the gellan gum and potassium chloride to prepare the empty capsule, and has the benefits that the disintegration is timely, moisture content is low, the empty capsule is suitable for medicines which have strong hygroscopicity and are sensitive to water, the influence of dissolved mediums on a capsule shell is small, the medication compliance is high, the storage period is long, the empty capsule can not go bad within 3-4 years, requirements on storage and transportation conditions are low, the empty capsule is less susceptible to fragmentation at a low-moisture environment, is insusceptible to deformation at a high-temperature environment, and has low probabilities of rottenness and deterioration; the empty capsule is made from pure vegetable fibers, and can meet requirements of all cultural backgrounds and religious groups; the manufacturing process is almost free from pollution, tailings can be again dissolved for reuse; frequently-used surface-active agents and plasticizers are eliminated, the gelating speed is accelerated only by using the potassium chloride to help the gellan gum to condense so as to reduce the gelating temperature, accordingly, the additives are reduced, and the production cost is reduced; the empty capsule is suitable for mass promotion.

Description

technical field [0001] The invention belongs to the technical field of hollow capsule production, in particular to a vegetable enteric hollow capsule prepared by using hypromellose as a raw material and comprising gellan gum and potassium chloride gel. Background technique [0002] The hollow capsule is composed of a cap and a two-section capsule shell refined from medicinal materials, and is used to hold solid medicines; such as homemade powders, health products, pharmaceuticals, etc., it solves the problems of difficult entrance and poor taste for users. The good medicine is no longer bitter; because the hollow capsule is easy to swallow, it can effectively mask the uncomfortable taste and smell of the content, and it is more and more popular with patients. [0003] The current hollow capsules mainly include animal gelatin capsules and various vegetable capsules. In my country, gelatin hollow capsules account for the vast majority. At present, gelatin hollow capsules have...

AI Technical Summary

Problems solved by technology

[0004] However, gelatin capsules obviously have the defect of slow disintegration speed. At the same time, the huge gelatin empty capsule market and its industrial chain have also brought many quality problems and safety risks.

After the "Chromium Exceeding Standard Capsule Incident", more attention has been paid to the safety issues of capsules; at the same time, with the occurrence of animal diseases such as "mad cow disease" and "foot-and-mouth disease", people have a lot of interest in making gelatin raw materials from animal leather and bones. There is great anxiety, the empty capsules mainly produced from animal gelatin have great potential safety hazards

[0005] In view of this, scientific research institutions at home and abroad have strengthened the research on plant-based capsules. So far, a variety of non-gelatin hollow capsules have been developed. 68%-88% pullulan, 10%-30% hypromellose, 1%-3% gel, 0.1%-0.5% coagulant, 0.1%-0.5% Surfactants and 0.1%-0.3% pigments are prepared into glue and dipped in glue. This patent solves the problems of slow disintegration speed and potential safety hazards of gelatin capsules, but it is obvious in the film-forming and storage stability of the capsule body. Not enough, it also has adverse effects on certain drugs in the capsule, and the surfactant in it has been expressly banned