Gellan gum and calcium chloride gelled hydroxypropyl methylcellulose enteric-coated hollow capsule

Abstract

The invention relates to a gellan gum and calcium chloride gelled hydroxypropyl methylcellulose enteric-coated hollow capsule, and belongs to the technical field of the production of hollow capsules. The hollow capsule is characterized in that the hollow capsule is prepared through mixing a main raw material hydroxypropyl methylcellulose with the gellan gum and calcium chloride under a special condition, the hollow capsule has the characteristics of timely disintegration, low water content, suitableness for medicines having strong hygroscopic property and being sensitive to water, small influences of a dissolve-out medium to the shell of the capsule, high drug compliance, long storage duration data, no deterioration within 3-4 years, low condition requirements on the storage and the transportation, difficult crushing in the low humidity environment, difficult deformation, putrefaction and deterioration in the high temperature environment, according with the requirements of populations having all culture backgrounds and religious faiths because of pure vegetable fibers, almost no pollution in the production process, secondary re-dissolving utilization of tailings, omission of the commonly-used surfactants and plasticizers, acceleration of the gelling speed by reducing the gelling temperature only through utilizing calcium chloride to assist the gellan gum, additive reduction, production cost reduction, and suitableness for the mass popularization.

Description

technical field [0001] The invention belongs to the technical field of hollow capsule production, in particular to a plant-based enteric-coated hollow capsule made of gellan gum and calcium chloride gel prepared from hypromellose. Background technique [0002] The hollow capsule is composed of a cap and a body made of refined medicinal materials, and is used to hold solid medicines; such as self-made powders, health products, medicines, etc., which solves the problems of difficult entrance and poor taste for users, and truly realizes The good medicine is no longer bitter; because the hollow capsules are easy to swallow and can effectively mask the unpleasant taste and smell of the contents, they are becoming more and more popular among patients. [0003] The current hollow capsules mainly include animal gelatin capsules and various vegetable capsules. In my country, gelatin hollow capsules account for the vast majority. At present, gelatin hollow capsules have been widely us...

AI Technical Summary

Problems solved by technology

[0004] However, gelatin capsules obviously have the defect of slow disintegration speed. At the same time, the huge gelatin empty capsule market and its industrial chain have also brought many quality problems and safety risks.

After the "Chromium Exceeding Standard Capsule Incident", more attention has been paid to the safety issues of capsules; at the same time, with the occurrence of animal diseases such as "mad cow disease" and "foot-and-mouth disease", people have a lot of interest in making gelatin raw materials from animal leather and bones. There is great anxiety, the empty capsules mainly produced from animal gelatin have great potential safety hazards

[0005] In view of this, scientific research institutions at home and abroad have strengthened the research on plant-based capsules. So far, a variety of non-gelatin hollow capsules have been developed. 68%-88% pullulan, 10%-30% hypromellose, 1%-3% gel, 0.1%-0.5% coagulant, 0.1%-0.5% Surfactants and 0.1%-0.3% pigments are prepared into glue and dipped in glue. This patent solves the problems of slow disintegration speed and potential safety hazards of gelatin capsules, but it is obvious in the film-forming and storage stability of the capsule body. Not enough, it also has adverse effects on certain drugs in the capsule, and the surfactant in it has been expressly banned