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A kind of hypromellose enteric-coated empty capsule with calcium salt and sodium salt gel

A technology of hypromellose and hollow capsules, which is applied in capsule delivery, medical preparations of non-active ingredients, inorganic non-active ingredients, etc. It can solve problems such as low production efficiency and large capsules, and improve moldability , low water content, easy storage effect

Active Publication Date: 2020-02-14
CHONGQING HENGSHENG MEDICINAL CAPSULE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after several years of production and use practice, it is found that when the patented method is used to produce hollow capsules, the proportion of microbubbles and uneven thickness on the capsule body is too large, and often about 30% of the products are unqualified, resulting in low production efficiency.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Take 50kg of hypromellose, put it into 110L of purified water at a temperature of 87°C, stir and mix it for 9 minutes, and then keep it for 60 minutes at a temperature of 80°C to obtain a hypromellose solution.

[0024] (2) Stir and swell 330 g of gellan gum in 110 L of purified water at a temperature of 40° C., then heat to 85° C. and keep it for 55 minutes to obtain gellan gum swelling liquid.

[0025] (3) Add the gellan gum swelling solution to the hypromellose solution at a temperature 4°C higher than that of the hypromellose solution, and add the hypromellose solution and the gellan gum swelling solution at the same temperature Pour into the mixing kettle at the same time and start stirring when pouring in. After pouring, keep stirring and mixing for 9 minutes, and then cool to 75°C to obtain hypromellose gel solution.

[0026] (4) Add 260 g of calcium chloride to the hypromellose gel solution, stir at a speed of 900 rpm for 2 minutes, then vacuumize and filter...

Embodiment 2

[0035] (1) Take 50kg of hypromellose, put it into 113L of purified water at a temperature of 92°C, stir and mix rapidly for 10 minutes, and then keep it standing at a temperature of 85°C for 75 minutes to obtain a hypromellose solution.

[0036](2) Stir and swell 357 g of gellan gum in 113 L of purified water at a temperature of 42.5° C., then heat to 90° C. and keep it for 60 minutes to obtain a gel swelling solution.

[0037] (3) Add the gellan gum swelling solution to the hypromellose solution at a temperature 5°C higher than that of the hypromellose solution, and add the hypromellose solution and the gellan gum swelling solution at the same temperature Pour into the mixing kettle at the same speed and start stirring when pouring in. After pouring, keep stirring and mixing for 10 minutes, and then cool to 80°C to obtain hypromellose gel solution.

[0038] (4) Add 271 g of calcium chloride to the hypromellose gel solution, stir at a speed of 1000 rpm for 2.5 min, then vacuum...

Embodiment 3

[0046] (1) Take 50kg of hypromellose, put it into 115L of purified water with a temperature of 97°C, stir and mix quickly for 11 minutes, and then keep it for 90 minutes at a temperature of 90°C to obtain a hypromellose solution;

[0047] (2) Stir and swell 380g of gellan gum in 115L of purified water at a temperature of 45°C, then heat to 95°C and keep it for 65 minutes to obtain a gel swelling solution;

[0048] (3) Add the gellan gum swelling solution to the hypromellose solution at a temperature 6°C higher than that of the hypromellose solution, and add the hypromellose solution and the gellan gum swelling solution at the same temperature Pour into the mixing tank at the same speed and start stirring when pouring in. After pouring, continue to stir and mix for 11 minutes, and then cool to 85°C to obtain hypromellose gel solution;

[0049] (4) Add 290 g of calcium chloride to the hypromellose gel solution, stir at a speed of 1100 rpm for 3 minutes, then vacuumize and filter...

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Abstract

The invention discloses a hydroxypropyl methylcellulose enteric empty capsule with calcium salt and sodium salt gel, and belongs to the technical field of production of empty capsules. The method comprises the steps that hydroxypropyl methylcellulose is stirred into purified water to obtain a hydroxypropyl methylcellulose solution, gel is mixed, and a hydroxypropyl methylcellulose colloid solution; the calcium salt is mixed to obtain a hydroxypropyl methylcellulose calcium gel solution, and then the sodium salt is mixed to obtain a hydroxypropyl methylcellulose colloidal solution; glue dippingis carried out to prepare the hydroxypropyl methylcellulose enteric empty capsule. The enteric empty capsule has the advantages that sodium alginate is added to improve the film forming property of the colloidal solution, the calcium salt is firstly mixed in the mixing process, then the sodium alginate is mixed so that the problem of uneven thickness during glue dipping can be effectively solved,a gel swelling solution is added and mixed when the temperature is higher than that of the hydroxypropyl methylcellulose solution, vacuum suction filtration and degassing are also used, then residualtiny bubbles in the solution can be completely released, the micro bubbles on the empty capsule body are basically completely eradicated, the product quality is effectively improved, and the production efficiency is improved.

Description

technical field [0001] The invention belongs to the technical field of hollow capsule production, in particular to a plant-based enteric-coated hollow capsule prepared by taking hypromellose as a raw material and gelling calcium salt and sodium salt. Background technique [0002] The hollow capsule is composed of a cap and a body made of refined medicinal materials, and is used to hold solid medicines; such as self-made powders, health products, medicines, etc., which solves the problems of difficult entrance and poor taste for users, and truly realizes Good medicine is no longer bitter; because capsule medicine is easy to swallow and can effectively mask the unpleasant taste and smell of the contents, it is becoming more and more popular among patients. [0003] Previous hollow capsules mainly include animal gelatin capsules and various vegetable capsules. In view of the various defects of the existing capsules, the company developed and applied for a patent number of 2013...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/38A61K47/36A61K47/02
Inventor 吴易果李全忠华玉容唐杰胡晓涛
Owner CHONGQING HENGSHENG MEDICINAL CAPSULE
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