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A kind of hypromellose enteric-coated empty capsule with calcium salt, potassium salt and sodium salt gel

A technology of hypromellose and hollow capsules, which is applied in the fields of capsule transportation, medical preparations of non-active ingredients, and pharmaceutical formulas, which can solve the problems of large capsules and low production efficiency, achieve low water content, and increase production costs. Modulus, non-perishable effect

Active Publication Date: 2021-01-01
CHONGQING HENGSHENG MEDICINAL CAPSULE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after several years of production and use practice, it is found that when the patented method is used to produce hollow capsules, the proportion of microbubbles and uneven thickness on the capsule body is too large, and often about 30% of the products are unqualified, resulting in low production efficiency.

Method used

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  • A kind of hypromellose enteric-coated empty capsule with calcium salt, potassium salt and sodium salt gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Take 50kg of hypromellose, put it into 120L of purified water at a temperature of 87°C, stir and mix rapidly for 9 minutes, and then keep it for 60 minutes at a temperature of 80°C to obtain a hypromellose solution.

[0026] (2) Stir and swell 430 g of gellan gum in 120 L of purified water at a temperature of 40° C., then heat to 85° C. and keep it for 55 minutes to obtain gellan gum swelling liquid.

[0027] (3) Add the gellan gum swelling solution to the hypromellose solution at a temperature 4°C higher than that of the hypromellose solution, and add the hypromellose solution and the gellan gum swelling solution at the same temperature Pour into the mixing kettle at the same time and start stirring when pouring in. After pouring, keep stirring and mixing for 9 minutes, and then cool to 75°C to obtain hypromellose gel solution.

[0028] (4) Add 210 g of calcium chloride to the hypromellose gel solution, stir at a speed of 900 rpm for 2 minutes, then vacuumize and f...

Embodiment 2

[0038] (1) Take 50kg of hypromellose, put it into 125L of purified water at a temperature of 92°C, stir and mix quickly for 13 minutes, and then keep it at a temperature of 85°C for 75 minutes to obtain a hypromellose solution.

[0039] (2) Stir and swell 466 g of gellan gum in 125 L of purified water at a temperature of 42.5° C., then heat to 90° C. and keep it for 60 minutes to obtain gellan gum swelling liquid.

[0040] (3) Add the gellan gum swelling solution to the hypromellose solution at a temperature 5°C higher than that of the hypromellose solution, and add the hypromellose solution and the gellan gum swelling solution at the same temperature Pour it into the mixing tank at the same time and start stirring when pouring in. After pouring, keep stirring and mixing for 13 minutes, and then cool to 80°C to obtain hypromellose gel solution.

[0041] (4) Add 235 g of calcium chloride to the hypromellose gel solution, stir at a speed of 1000 rpm for 2.5 min, then vacuumize and...

Embodiment 3

[0050] (1) Take 50kg of hypromellose, put it into 130L of purified water at a temperature of 98°C, stir and mix rapidly for 17 minutes, and then keep it standing for 90 minutes at a temperature of 92°C to obtain a hypromellose solution.

[0051] (2) Stir and swell 490 g of gellan gum in 130 L of purified water at a temperature of 45° C., then heat to 95° C. and keep it for 65 minutes to obtain gellan gum swelling liquid.

[0052] (3) Add the gellan gum swelling solution to the hypromellose solution at a temperature 6°C higher than that of the hypromellose solution, and add the hypromellose solution and the gellan gum swelling solution at the same temperature Pour into the mixing tank at the same time and start stirring when pouring in. After pouring, keep stirring and mixing for 17 minutes, and then cool to 85°C to obtain hypromellose gel solution.

[0053] (4) Add 250 g of calcium chloride to the hypromellose gel solution, stir at a speed of 1100 rpm for 3 minutes, then vacuu...

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Abstract

The invention relates to a hydroxypropyl methylcellulose enteric hollow capsule gelling calcium salt, potassium salt and sodium salt, and belongs to the technical field of hollow capsule production. The capsule is prepared by the following steps: stirring hydroxypropyl methylcellulose in purified water to obtain a hydroxypropyl methylcellulose solution; adding a gelling agent to obtain a hydroxypropyl methylcellulose gel solution; adding calcium salt to obtain a calcium gel solution; adding potassium salt to obtain a calcium potassium gel solution; adding sodium salt to obtain a colloidal solution; and performing glue dipping to obtain the hydroxypropyl methylcellulose enteric hollow capsule. The invention has the beneficial effects that: a proper amount of sodium alginate improves the modeling property of the colloidal solution, and the calcium salt, the potassium salt and the sodium alginate are sequentially added into the hydroxypropyl methylcellulose colloidal solution, so that theproblem of uneven thickness during glue dipping can be greatly reduced; and when the temperature of a gel agent swelling liquid is higher than that of the hydroxypropyl methylcellulose solution, thegel agent swelling liquid is added with vacuum filtration and degassing, so that the fine bubbles in the solution can be completely released, the fine bubbles on the hollow capsule body are basicallyeliminated, the product quality is effectively improved, and the production efficiency is improved.

Description

technical field [0001] The invention belongs to the technical field of hollow capsule production, in particular to a plant-based enteric-coated hollow capsule prepared by using hypromellose as a raw material and gelling calcium salt, potassium salt and sodium salt. Background technique [0002] The hollow capsule is composed of a cap and a body made of refined medicinal materials, and is used to hold solid medicines; such as self-made powders, health products, medicines, etc., which solves the problems of difficult entrance and poor taste for users, and truly realizes The good medicine is no longer bitter; because the hollow capsules are easy to swallow and can effectively mask the unpleasant taste and smell of the contents, they are becoming more and more popular among patients. [0003] Previous hollow capsules mainly include animal gelatin capsules and various vegetable capsules. In view of the various defects of the existing capsules, the company developed and applied f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/38A61K47/36
Inventor 李全忠吴易果华玉容唐杰胡晓涛
Owner CHONGQING HENGSHENG MEDICINAL CAPSULE
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