Hydroxypropyl methylcellulose enteric-coated hollow capsules prepared through gel coagulation of potassium salt and sodium salt

Abstract

The invention relates to hydroxypropyl methylcellulose enteric-coated hollow capsules prepared through gel coagulation of potassium salt and sodium salt, and belongs to the technical field of the production of hollow capsules. The hydroxypropyl methylcellulose enteric-coated hollow capsules are prepared through the steps of stirring hydroxypropyl methylcellulose and purified water to obtain a hydroxypropyl methylcellulose solution, then performing infiltration with gelata to obtain a hydroxypropyl methylcellulose colloid solution, then performing infiltration with the potassium salt to obtaina hydroxypropyl methylcellulose potassium gel solution, then performing infiltration with the sodium salt to obtain a hydroxypropyl methylcellulose gelatine solution, and then performing gel dipping so as to obtain the hydroxypropyl methylcellulose enteric-coated hollow capsules. The hydroxypropyl methylcellulose enteric-coated hollow capsules have the beneficial effects that sodium alginate is added, so that the mold forming properties of the gelatine solution are increased; the potassium salt is firstly infiltrated with the solution, and then the sodium alginate is infiltrated, so that the problem of uneven thickness of gel dipping can be well solved; gelata swelling liquid is added and mixed when the temperature of the gelata swelling liquid is higher than that of the hydroxypropyl methylcellulose solution, and vacuum filtration degassing is combined, so that residual fine bubbles in the solution can be thoroughly released, fine bubbles on hollow capsule bodies can be basically avoided, the quality of products can be effectively increased, and the production efficiency is improved.

Description

technical field [0001] The invention belongs to the technical field of hollow capsule production, in particular to a plant-based enteric-coated hollow capsule prepared by using hypromellose as a raw material and gelling potassium salt and sodium salt. Background technique [0002] The hollow capsule is composed of a cap and a body made of refined medicinal materials, and is used to hold solid medicines; such as self-made powders, health products, medicines, etc., which solves the problems of difficult entrance and poor taste for users, and truly realizes The good medicine is no longer bitter; because the hollow capsules are easy to swallow and can effectively mask the unpleasant taste and smell of the contents, they are becoming more and more popular among patients. [0003] Previous hollow capsules mainly include animal gelatin capsules and various vegetable capsules. In view of the various defects of the existing capsules, the company developed and applied for a patent nu...

AI Technical Summary

Problems solved by technology

However, after several years of production and use practice, it is found that when the patented method is used to produce hollow capsules, the proportion of microbubbles and uneven thickness on the capsule body is too large, and often about 30% of the products are unqualified, resulting in low production efficiency.

Images