Hydroxypropyl methylcellulose enteric-coated hollow capsules prepared through gel coagulation of potassium salt and sodium salt

A technology of hypromellose and hollow capsules, which is applied in capsule delivery, medical preparations of non-active ingredients, pharmaceutical formulas, etc., can solve the problems of large capsules and low production efficiency, achieve low water content, and increase production costs. Modulus, reducing the effect of additives

Active Publication Date: 2019-06-07
CHONGQING HENGSHENG MEDICINAL CAPSULE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after several years of production and use practice, it is found that when the patented method is used to produce hollow capsules, the proportion of m

Method used

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  • Hydroxypropyl methylcellulose enteric-coated hollow capsules prepared through gel coagulation of potassium salt and sodium salt

Examples

Experimental program
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Effect test

Embodiment 1

[0023] (1) Take 50kg of hypromellose, put it into 120L of purified water at a temperature of 85°C, stir and mix rapidly for 13 minutes, and then keep it for 60 minutes at a temperature of 82°C to obtain a hypromellose solution.

[0024] (2) Stir and swell 270 g of gellan gum in 120 L of purified water at a temperature of 40° C., then heat to 85° C. and keep it for 55 minutes to obtain gellan gum swelling liquid.

[0025] (3) Add the gellan gum swelling solution to the hypromellose solution at a temperature 3°C higher than that of the hypromellose solution, and add the hypromellose solution and the gellan gum swelling solution at the same temperature Pour into the mixing tank at the same speed and start stirring when pouring in. After pouring, keep stirring and mixing for 13 minutes, and then cool to 75°C to obtain hypromellose gel solution.

[0026] (4) Add 270 g of potassium chloride to the hypromellose gel solution, stir at a speed of 900 rpm for 2 minutes, then vacuumize an...

Embodiment 2

[0035] (1) Take 50kg of hypromellose, put it into 125L of purified water at a temperature of 92°C, stir and mix rapidly for 15 minutes, and then keep it standing at a temperature of 85°C for 75min to obtain a hypromellose solution.

[0036] (2) Stir and swell 357 g of gellan gum in 125 L of purified water at a temperature of 42.5° C., then heat to 90° C. and keep it for 60 minutes to obtain gellan gum swelling liquid.

[0037](3) Add the gellan gum swelling solution to the hypromellose solution at a temperature 4°C higher than that of the hypromellose solution, and add the hypromellose solution and the gellan gum swelling solution at the same temperature Pour into the mixing tank at the same time and start stirring when pouring in. After pouring, keep stirring and mixing for 15 minutes, and then cool to 80°C to obtain hypromellose gel solution.

[0038] (4) Add 286 g of potassium chloride to the hypromellose gel solution, stir at a speed of 1000 rpm for 2.5 minutes, then vacuu...

Embodiment 3

[0046] (1) Take 50kg of hypromellose, put it into 130L of purified water at a temperature of 98°C, stir and mix rapidly for 17 minutes, and then keep it standing for 90 minutes at a temperature of 92°C to obtain a hypromellose solution.

[0047] (2) Stir and swell 405 g of gellan gum in 130 L of purified water at a temperature of 45° C., then heat to 95° C. and keep it for 65 minutes to obtain gellan gum swelling liquid.

[0048] (3) Add the gellan gum swelling solution to the hypromellose solution at a temperature 5°C higher than that of the hypromellose solution, and add the hypromellose solution and the gellan gum swelling solution at the same temperature Pour into the mixing tank at the same time and start stirring when pouring in. After pouring, keep stirring and mixing for 17 minutes, and then cool to 85°C to obtain hypromellose gel solution.

[0049] (4) Add 310 g of potassium chloride to the hypromellose gel solution, stir at a speed of 1100 rpm for 3 minutes, then vac...

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Abstract

The invention relates to hydroxypropyl methylcellulose enteric-coated hollow capsules prepared through gel coagulation of potassium salt and sodium salt, and belongs to the technical field of the production of hollow capsules. The hydroxypropyl methylcellulose enteric-coated hollow capsules are prepared through the steps of stirring hydroxypropyl methylcellulose and purified water to obtain a hydroxypropyl methylcellulose solution, then performing infiltration with gelata to obtain a hydroxypropyl methylcellulose colloid solution, then performing infiltration with the potassium salt to obtaina hydroxypropyl methylcellulose potassium gel solution, then performing infiltration with the sodium salt to obtain a hydroxypropyl methylcellulose gelatine solution, and then performing gel dipping so as to obtain the hydroxypropyl methylcellulose enteric-coated hollow capsules. The hydroxypropyl methylcellulose enteric-coated hollow capsules have the beneficial effects that sodium alginate is added, so that the mold forming properties of the gelatine solution are increased; the potassium salt is firstly infiltrated with the solution, and then the sodium alginate is infiltrated, so that the problem of uneven thickness of gel dipping can be well solved; gelata swelling liquid is added and mixed when the temperature of the gelata swelling liquid is higher than that of the hydroxypropyl methylcellulose solution, and vacuum filtration degassing is combined, so that residual fine bubbles in the solution can be thoroughly released, fine bubbles on hollow capsule bodies can be basically avoided, the quality of products can be effectively increased, and the production efficiency is improved.

Description

technical field [0001] The invention belongs to the technical field of hollow capsule production, in particular to a plant-based enteric-coated hollow capsule prepared by using hypromellose as a raw material and gelling potassium salt and sodium salt. Background technique [0002] The hollow capsule is composed of a cap and a body made of refined medicinal materials, and is used to hold solid medicines; such as self-made powders, health products, medicines, etc., which solves the problems of difficult entrance and poor taste for users, and truly realizes The good medicine is no longer bitter; because the hollow capsules are easy to swallow and can effectively mask the unpleasant taste and smell of the contents, they are becoming more and more popular among patients. [0003] Previous hollow capsules mainly include animal gelatin capsules and various vegetable capsules. In view of the various defects of the existing capsules, the company developed and applied for a patent nu...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/38A61K47/36
Inventor 吴易果李全忠华玉容唐杰胡晓涛
Owner CHONGQING HENGSHENG MEDICINAL CAPSULE
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