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Preparation method of Longmu Zhuanggu granule

A technology for strengthening bones and granules of Longmu, which is applied to medical preparations containing active ingredients, bone diseases, and pharmaceutical formulas. It can solve the problems of large dosage, high production cost, and poor compliance of medication, and achieve the goal of reducing dosage. Effect

Active Publication Date: 2014-11-19
JIANMIN PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to improve the preparation method of Longmu Zhuanggu Granules to overcome the defects of large dosage, high production cost and poor compliance of taking medicine.

Method used

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  • Preparation method of Longmu Zhuanggu granule
  • Preparation method of Longmu Zhuanggu granule
  • Preparation method of Longmu Zhuanggu granule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] prescription:

[0022]

[0023] Preparation method:

[0024] 1) For the above sixteen flavors, make tortoise shell and schisandra vinegar, stir-fry Atractylodes macrocephala and gallinaceous gold, forge oysters, and set aside;

[0025] 2) Grind the stir-fried gallinaceous gold into fine powder and set aside;

[0026] 3) Take the nine flavors of Codonopsis pilosula, Astragalus root, Ophiopogon japonicus, Atractylodes macrocephala, Chinese yam, Schisandra chinensis, Poria cocos, jujube, and licorice, add water to boil three times, each time for 2 hours, combine the decoction, and filter; tortoise shell, keel, and oyster add water to decoct the three flavors Boil four times, 2 hours each time, combine the decoction, filter, combine the filtrate with Codonopsis pilosula and other extracts, and concentrate to a clear paste with a relative density of 1.05-1.10;

[0027] 4) AB-8 type macroporous adsorption resin column (1368g AB-8 type resin packing column of 1368g AB-8 t...

Embodiment 2

[0030] The 1st, 2nd, 3rd, 5th steps of prescription and preparation method are all identical with embodiment 1, difference is that step 4) is: the DA-201 type macroporous adsorption resin column (684g DA-201 type resin Pack the column, the weight of the resin is 2 times of the weight of the medicinal material), elute with 30% ethanol 11.3L (15 times the volume of the macroporous adsorption resin column), collect the eluate, and concentrate into a thick paste.

Embodiment 3

[0032] The 1st, 2nd, 3rd, 5th steps of prescription and preparation method are all identical with embodiment 1, difference is that step 4) is: the DA-201 type macroporous adsorption resin column (1710g DA-201 type resin Pack the column, the weight of the resin is 5 times of the weight of the medicinal material), elute with 15L of 60% ethanol (8 times the volume of the macroporous adsorption resin column), collect the eluate, and concentrate into a thick paste.

[0033] Embodiment 1-3 is compared with the comparative example 1 that does not carry out macroporous resin adsorption (feeding amount and other steps in the preparation method are identical with embodiment 1), and the results are shown in the following table:

[0034]

[0035] As can be seen from the results, after the macroporous resin is used for adsorption, the total amount of the Chinese medicine extract is greatly reduced, thereby correspondingly reducing the auxiliary materials required for the prepara...

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Abstract

The invention discloses a preparation method of a Longmu Zhuanggu granule. The preparation method comprises the steps of adding a process of carrying out macroporous resin adsorption on clear paste on the basis of the original Longmu Zhuanggu granule preparation process, eluting by using 30-60% ethyl alcohol, collecting the eluant and concentrating to thick paste. According to the preparation method, the gross of the traditional Chinese medicine extract can be decreased; compared with the process without macroporous resin adsorption, the preparation method disclosed by the invention has the advantages that the gross of the extract can be decreased by 42.5%; most strikingly, the decrease of the gross of the extract does not cause effect reduction; on the premise of taking traditional Chinese medicinal material with same dosage, the effect is not much different from the original method, so that the taking dosage of the Longmu Zhuanggu granule can be decreased. The decrease of the taking dosage is beneficial to decreasing the accessories, reducing the cost, reducing the preparation specification, improving the taking compliance, reducing the bitterness of the drug and improving the taste of the granule during taking after mixing with water.

Description

technical field [0001] The invention relates to a preparation method of traditional Chinese medicine, in particular to a preparation method of Longmu Zhuanggu Granules. Background technique [0002] CN1466976A discloses a medicine for preventing and treating rickets and osteoporosis and a preparation method thereof. The medicine belongs to a compound preparation of Chinese and Western medicines, and is compatible with Chinese medicines for invigorating the spleen and invigorating the kidney, so as to exert the effects of invigorating the spleen and stomach, and strengthening tendons and bones. It is used for the treatment and prevention of rickets and rickets in children. The drug has a history of more than 20 years of clinical application. It is an exclusive product of Wuhan Jianmin Pharmaceutical Group Co., Ltd., and its product name is Longmu Zhuanggu Granules. It is a well-known trademark in China and a national protected product of traditional Chinese medicine. "2010 e...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61K9/16A61P19/08A61P19/10A61K35/56A61K35/37A61K31/19A61K31/592
Inventor 黄志军赵刚肖飞向阳朱立彬
Owner JIANMIN PHARMA GRP CO LTD
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