Film-forming gel composition, application and wound protecting material
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A gel composition and film-forming technology, which can be used in drug combinations, medical preparations containing active ingredients, medical science, etc., can solve the problems of secondary wound damage, insufficient tightness, poor mechanical strength and flexibility, etc.
Inactive Publication Date: 2015-11-04
SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
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Problems solved by technology
[0014] The technical problem to be solved by the present invention is to overcome the fact that the solid band-aid type wound-protecting preparations in the prior art are easy to cause secondary damage to the wound surface, accumulated water and scale, resulting in infection, limited use size, inability to adhere to the wound, poor flexibility, and inability to make the affected area To overcome the defects of the wetness of the liquid band-aids in the prior art, they are poor in air permeability, easy to cause stuffy, itching, dampness, allergies and other adverse side effects, or they are not hydrophobic, have poor mechanical strength and flexibility, and are difficult to completely peel off , easy to stick to dust and the adhesion between the film and the skin is not tight enough, poor wear resistance, easy to be erased, etc., and to overcome some film-forming gel compositions mostly use aromatic organic carboxylic acids with pharmacological activity as esterification agents, which is inevitable It exists in the film-forming gel composition in a free state, thereby producing pharmacological effects on the human body and causing adverse reactions. A film-forming gel composition, its use, and wound-protecting materials are provided.
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Embodiment 6-20
[0098] The composition and content thereof of the drug film-forming gel composition of embodiment 6-20 are as shown in table 1:
[0099] The composition and content thereof of the drug film-forming gel composition of table 2 embodiment 6-20
[0100]
[0101]
[0102] The hydroxypropyl cellulose in the above table is the hydroxypropyl cellulose Kluce series produced by the Aqualon Functional Materials Department of Ashland, USA.
[0103] Embodiment 1-20, according to the component of each embodiment and comparative example in table 1 and table 2, content prepares 1000 grams of film-forming gel wound protection films according to the following method respectively:
[0104] 1. Add appropriate amount of solvent and antibacterial agent into the container, stir evenly, add esterification agent, stir to dissolve;
[0105] 2. While stirring homogeneously, slowly add hydroxypropyl cellulose, so that the hydroxypropyl cellulose can be dispersed into the solvent as soon as it comes ...
Embodiment 21-26
[0108] The composition and content thereof of the drug film-forming gel composition of embodiment 21-26 are as shown in table 3:
[0109] The composition and content thereof of the drug film-forming gel composition of table 3 embodiment 21-26
[0110]
[0111]
[0112] With benzalkonium chloride, chlorhexidine acetate, povidone iodine, erythromycin, mupirocin, clotrimazole, and aloe extract as model drugs, the components in Table 3 were prepared according to the preparation of Examples 1-5 Methods 1000 grams of drug film-forming gel compositions were prepared respectively.
[0113] The pharmaceutical film-forming gel composition prepared in Table 3 is a translucent semi-solid gel in appearance and has an ethanol smell, and can form a smooth, tough, wear-resistant, and durable hydrophobic film on the skin.
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Abstract
The invention discloses a film-forming gel composition, its application and a wound protecting material. The film-forming gel composition comprises the following ingredients: hydroxy propyl cellulose, an esterifying agent, a cross-linking agent and a solvent, wherein the esterifying agent contains saturated fatty hydroxy carboxylic acid and tannic acid. The chemical general formula of the saturated fatty hydroxy carboxylic acid is CnH2n+2-m-L(OH)m(COOH)L, wherein n, m and L are integers; n is greater than or equal to 1; m is greater than or equal to 1; L is greater than or equal to 1; m+L is 2-5; and n+L is 2-6. The film-forming gel composition can be used to prepare a drug for treating skin or oral mucosal diseases, or can be used as a drug carrier to prepare a drug film-forming gel composition and a wound protecting material. The film-forming gel composition contains no aromatic organic carboxylic acid with pharmacological activity, will not produce pharmaceutical action on human body and also will not cause adverse reactions on human body.
Description
technical field [0001] The invention relates to a film-forming gel composition, its use and a wound-protecting material. Background technique [0002] Human skin is caused by cuts, abrasions, incisions, scalds, etc., or skin inflammation caused by bacteria, fungi or viruses, is a common disease that people often encounter in daily life. The general treatment measures are to clean the wound, stop bleeding, disinfect, and then use wound protection preparations to protect the wound surface and prevent infection. [0003] At present, most of the commonly used topical skin protection preparations are solid bandage-like "Band-Aid" products. This product is a long-shaped adhesive plaster composed of elastic textiles and adhesive plaster adhesives. The inner layer is attached with a strong absorbent It is a protective composite pad composed of a special absorbent pad and a layer of isolation permeable membrane. The absorbent pad has two types: drug-containing and drug-free, which h...
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Application Information
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