Medical nano-silver and cerium emulsion and preparation method thereof

A technology of silver-cerium emulsion and nano-silver particles, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, local antibacterial agents, etc., can solve the problems of poor microbial infection effect, and achieve the promotion of epithelial cell growth and good permeability , beneficial to the effect of regeneration

Inactive Publication Date: 2012-09-19
SHANGHAI UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In particular, it can only be used to kill superficial microorganisms, and has poor effect on deeper microbial infections. For other infected wounds, topical antibiotics or hormonal topical drugs are generally used.

Method used

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  • Medical nano-silver and cerium emulsion and preparation method thereof
  • Medical nano-silver and cerium emulsion and preparation method thereof
  • Medical nano-silver and cerium emulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] a. Preparation of oil phase materials: take 80 grams of stearic acid, 20 grams of glyceryl monostearate, and 60 grams of stearyl alcohol, heat and stir, and after melting at 85-95 °C, add 1 gram of antioxidant to Hydroxybenzoic acid, keep for 10 minutes;

[0047] b. Preparation of water phase materials: Take 100 grams of glycerol and add the remaining distilled water, heat and stir to 85-95 °C, add 8 grams of sodium hydroxide and stir again;

[0048]c. Heat the water phase material into the emulsification neutralization tank, heat and stir, then flow the oil phase material into the emulsification neutralization tank for emulsification, adjust the pH value to 6, and keep the temperature in the tank at 85-95°C Stop heating after 10 minutes, and the speed of the agitator in the emulsification neutralization tank is 80-100 rpm;

[0049] d. When the temperature in the emulsification neutralization tank drops to 55-60°C, put in a mixture of 12 grams of rare earth cerium salt...

Embodiment 2

[0057] a. Take 12 grams of rare earth cerium salt and add 50 grams of distilled water at a temperature of 60 ° C to stir, and set aside;

[0058] b. Take 12 grams of ribose, add 100 grams of distilled water at 60°C and stir, set aside;

[0059] c. Take 6 grams of nano-silver particles, add 30 grams of distilled water at 60°C, place in an ultrasonic bath for 10 minutes, shake well, and set aside;

[0060] d. Mix the above three aqueous solutions and set aside.

[0061] e. Take 10 grams of sodium polyacrylic acid G57, add the remaining amount of distilled water and stir evenly, then add the above three aqueous solutions and stir evenly again, and it is ready.

Embodiment 3

[0063] a. Take 12 grams of rare earth cerium salt and add 50 grams of distilled water at a temperature of 60 ° C to stir, and set aside;

[0064] b. Take 12 grams of ribose, add 100 grams of distilled water at 60°C and stir, set aside;

[0065] c. Take 6 grams of nano-silver particles, add 30 grams of distilled water at 60°C, place in an ultrasonic bath for 10 minutes, shake well, and set aside;

[0066] d. Mix the above three aqueous solutions, add the remaining amount of distilled water and stir, set aside.

[0067] e. After impregnating the above mixed aqueous solution with non-woven fabric or degreasing gauze, the wound can be covered.

[0068] Animal Test 1

[0069] ①Materials and methods

[0070] a. Laboratory animals

[0071] 80 purebred Wistar rats, male, weighing 180-200 grams, were provided by the Breeding Center of the Second Military Medical University.

[0072] b. Burn model

[0073] After the rats were weighed, they were anesthetized with pentobarbital (35m...

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Abstract

The invention relates to a medical nano-silver and cerium emulsion and a preparation method of the emulsion; in a formula combination of the emulsion, basic raw materials contains rare earth cerate, nano-silver particles and ribose as a main body; an oil phase of auxiliary materials comprises stearic acid, monoglyceride, octadecanol and para-hydroxybenzoic acid, and a water phase of the auxiliary materials comprises sodium hydroxide and glycerol; the emulsion prepared by emulsifying above materials has good actions of protecting wounds and prompting tissue regeneration on various wound surfaces of skins and mucosas; effective rate of the emulsion is more than 95%. For infectious wound of skins, the emulsion can fast and effectively inhibit and sterilize various microorganisms, and generate less drug resistance, and effective rate of the emulsion is more than 98%. For cured ulcer, the emulsion also can fast and effectively cultivate organizations such as basement meat, and can be beneficial to regeneration of epithelial tissue and accelerate wound healing, and the effective rate of the emulsion is more than 93%.

Description

technical field [0001] The invention relates to a medical nano-silver cerium emulsion and a preparation method thereof. Background technique [0002] The normal surface skin and mucous membrane of the human body are eroded by various reasons from the external environment, including physical trauma such as burns, wounds, and blast injuries, as well as trauma caused by chemical and microbial infections. The physical and chemical properties and tissue structure of the normal skin are destroyed and a natural barrier is lost. At this time, the normal surface tissue structure loses its original anti-epidemic function, and the immune regulation of the human body is out of balance, which promotes the accumulation and reproduction of a large number of bacteria on the wound surface, leading to primary and secondary infections, and the normal surface tissue structure is difficult to obtain. recovery, seriously affecting the health of patients and even threatening the lives of patients...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/38A61K9/107A61P17/02A61P31/02A61K33/24A61K31/7105
Inventor 张晓亮严根荣孔秀龙梁琥琪
Owner SHANGHAI UNIV
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