Double-layered composite biological dressing and adhesive-free compound technology thereof

A biological dressing, double-layer composite technology, applied in medical science, absorbent pads, bandages, etc., can solve the problems of increased ingredients, hazards, etc., and achieve the effect of preventing wound infection, non-cytotoxicity, and safe use

Active Publication Date: 2014-12-10
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Adhesive adhesive compounding method is used to introduce adhesive into the dressing, which brings unnecessary increase of ingredients and potential harm

Method used

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  • Double-layered composite biological dressing and adhesive-free compound technology thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Divide 20*20cm 2 100g / m 2 The chitosan fiber needle-punched non-woven fabric was laid flat on a stainless steel freezing tray, sprayed with 30ml RO pure water on the surface of the non-woven fabric, placed in an ultra-low temperature refrigerator, and pre-frozen at -40°C for 30 minutes; prepared the sponge layer material solution, the total concentration 3.5wt%, weighed 1.1g of macromolecular chitosan, 0.3g of small molecular chitosan, 1.1g of macromolecular collagen, and 0.3g of small molecular collagen, dissolved in 80ml of 0.5wt% acetic acid aqueous solution, and uniformly Stir the pulper to a uniform state, ultrasonically degas, and store at 20°C; take out the pre-frozen chitosan non-woven fabric freezing plate, and quickly spray the sponge layer raw material solution on the non-woven fabric evenly, with a spray volume of 40ml / 20* 20cm 2 , and the operation time is less than 5 minutes; then put it into an ultra-low temperature refrigerator, freeze at -50°C for 60 ...

Embodiment 2

[0035] Divide 20*20cm 2 100g / m 2The chitosan fiber needle-punched non-woven fabric was laid flat on a stainless steel freezing tray, sprayed 40ml RO pure water on the surface of the non-woven fabric, placed in an ultra-low temperature refrigerator, and pre-frozen at -40°C for 30 minutes; prepared the sponge layer material solution, the total concentration 2.5wt%, weighed 0.8g macromolecular chitosan, 0.2g small molecular chitosan, 0.8g macromolecular collagen, 0.2g small molecular collagen, dissolved in 80ml 0.5wt% acetic acid aqueous solution, and homogenized at room temperature Stir with machine until uniform, ultrasonic degassing, and store at 20°C; take out the pre-frozen chitosan non-woven fabric freezing plate, and quickly spray the sponge layer raw material solution on the non-woven fabric evenly, with a spray volume of 60ml / 20*20cm 2 , and the operation time is less than 5 minutes; then put it into an ultra-low temperature refrigerator, freeze at -40°C for 60 minutes,...

Embodiment 3

[0039] Divide 20*20cm 2 100g / m 2 The chitosan fiber needle-punched non-woven fabric was laid flat on a stainless steel freezing tray, sprayed with 30ml RO pure water on the surface of the non-woven fabric, placed in an ultra-low temperature refrigerator, and pre-frozen at -30°C for 30 minutes; prepared the sponge layer material solution, the total concentration 2.0wt%, weighed 0.8g of macromolecular chitosan, 0.2g of small molecular chitosan, 0.8g of macromolecular collagen, and 0.2g of small molecular collagen, dissolved in 0.5% acetic acid aqueous solution of 100ml, and uniformly Stir the pulper to a uniform state, ultrasonically degas, and store at 20°C; take out the pre-frozen chitosan non-woven fabric freezing plate, and quickly spray the sponge layer raw material solution evenly on the non-woven fabric with a spray volume of 50ml / 20* 20cm 2 , the operation time is less than 5 minutes; then put it into a low-temperature refrigerator, freeze at -40°C for 60 minutes, quic...

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Abstract

The invention provides a double-layered composite biological dressing and an adhesive-free compound technology thereof. The double-layered composite dressing comprises a chitosan fiber non-woven fabric layer and a spongy-shaped functional layer, wherein no adhesive is needed to bond the two layers. The preparation technology comprises the following steps: (1) chitosan fiber non-woven fabric is pre-cooled; (2) macromolecule chitosan, macromolecule collagen protein, micromolecule collagen protein and micromolecule chitosan in mass ratio of 0.7-1.3 to 0.1-0.3 to 0.7-1.3 to 0.1-0.3 are added in a faintly acid aqueous solution to prepare a spongy layer material solution; (3) the pre-cooled chitosan non-woven fabric is taken out and the spongy layer material solution is rapidly and uniformly sprayed on the non-woven fabric, wherein the spraying amount is 20-60 ml / 20*20 cm<2>; (4) the chitosan non-woven fabric sprayed with the spongy layer material solution is freeze-dried. The prepared double-layered composite dressing is firm in embedding connection between the two layers; the spongy functional layer has the function of promoting wound healing and prevents adhesion; the chitosan fiber non-woven fabric layer has the functions of favorable air permeability, comfort and bacterium resistance.

Description

technical field [0001] The invention belongs to the field of preparation of medical wound dressings, and in particular relates to a double-layer composite biological dressing and an adhesive-free composite process thereof. Background technique [0002] After skin trauma or burns. It is usually necessary to protect the wound surface with a wound dressing with excellent performance and provide an environment conducive to wound healing. For deep second-degree wounds or burns, in addition to the necessary wound protection and antibacterial functions, the dressing also needs to have the function of promoting the regeneration of residual epithelium and accelerating wound healing until the permanent skin barrier is rebuilt. [0003] Chitosan has good wound-protecting and hemostatic properties, antibacterial properties, and strong biocompatibility. Chitosan fiber non-woven fabrics can be used as wound dressings. However, because chitosan fiber is easy to adhere to the wound, the n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/28A61L15/44A61L15/42
Inventor 郭养浩郑允权石贤爱
Owner FUZHOU UNIV
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