Exterior use prepn. for treating skin trauma

A technology for external preparations and skin wounds, applied in the field of external preparations for the treatment of skin wounds, can solve the problems of ineffective antibacterial and bactericidal effects, tissue invasion, poor permeability, etc., to achieve good protection of wounds, accelerated healing, and beneficial regeneration Effect

Inactive Publication Date: 2003-05-21
SHANGHAI UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Existing traditionally used external preparations such as silver sulfadiazine and other creams have some shortcomings in use, mainly in: 1. The effect of bacteriostatic and bactericidal is not very obvious, and the persistence is poor
2. Poor permeability of preparations, often only acting on the surface
3. It also has a certain damage to normal tissues, and has no effect on tissue repair
4. There are obvious allergies and no effect on the growth of epithelial cells and the immune regulation of local tissues

Method used

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  • Exterior use prepn. for treating skin trauma
  • Exterior use prepn. for treating skin trauma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1: see figure 1 , The specific preparation method of the cream of the external preparation of the present invention can be divided into the following steps. Present embodiment is example with preparing 1000 grams (1 kilogram) cream for external use:

[0046] a. Preparation of oil phase materials: Take 140 grams of stearic acid and 30 grams of glyceryl monostearate, mix and heat until melted, and keep at 70-90°C for 1 hour;

[0047] b. Preparation of water phase materials: Take 10 grams of sodium hydroxide and add 745 grams of distilled water, after melting, add 50 grams of glycerin and heat to 70-90 °C;

[0048] c. Heat the water phase material and flow it into the emulsification neutralization tank, heat and stir, and then flow the oil phase material into the emulsification neutralization tank for emulsification. The speed of the agitator in the emulsification neutralization tank is 80-100 rpm Minute;

[0049] d. After emulsification and stirring, at a tempe...

Embodiment 2

[0052] Embodiment 2: the preparation method of the water preparation of the present invention is: get 10 grams of rare earth cerium salts, 10 grams of ribose, 5 grams of silver nitrate, dissolve in 975 grams of water distillation, stir to make it fully dissolve, then canned. The water agent of the present invention can be sprayed on the wound surface by spraying or brushing, or can be covered on the affected part after being impregnated with degreasing gauze, non-woven fabric or absorbable resin.

Embodiment 3

[0053] Embodiment 3: The preparation method of the paste of the present invention is: take 100 grams of starch and add 896.5 grams of distilled water, stir and heat to 70-95 ° C, after the starch is fully dissolved, cool to 55-70 ° C, then add 1 gram of rare earth Cerium salts, 2 grams of ribose and 0.5 gram of soluble silver salt are fully stirred, then cooled and canned, and the obtained product is a paste.

[0054]In addition, the preparation containing the pharmaceutical ingredient of the present invention can also be coated on a fabric with better air permeability by means of coating to make a plaster.

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PUM

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Abstract

The present invention relates to a preparation for external application for curing wound of skin. Its prescription composition contains stearic acid, glyceryl monostearate and glycerin as basic medicinal raw material, and contains special additives, such as rare earth cerium salt, ribose and soluble silver salt compound, etc. and its preparation method includes the following steps: heating stearic acid 14% and glyceryl monostearate 3% (oil phase) and melting them, heat-insulating at 70-90 deg.C for 1 hr; adding glycerin 5% into distilled water 74% (water phase) heating to 70-92 deg.C or adding sodium hydroxide 1% into distilled water and dissolving, then adding glycerin 5% (water phase), heating to 70-90 deg.C, slowly adding oil phase, stirring and cooling, adding rare earth cerium salt, ribose and soluble silver salt.

Description

technical field [0001] The invention relates to an external preparation for treating skin wounds, and belongs to the field of medical chemical medicine manufacture. Background technique [0002] The normal surface skin structure and mucous membranes of the human body are damaged and invaded by physical, chemical, and microbial factors in the external environment, and lose their original defense functions. There are secondary and secondary infections, and it is difficult to restore the normal surface tissue structure, which seriously affects people's life and work, especially in the field of burn surgery. [0003] Existing traditionally used external preparations such as silver sulfadiazine and other creams have some shortcomings in use, mainly as follows: 1. The effect of bacteriostatic and bactericidal is not very obvious, and the persistence is poor. 2. The preparation has poor permeability and often only acts on the surface. 3. It also has a certain damage to normal tis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7088A61K33/24A61P17/02
Inventor 陈国华张晓亮严根荣梁琥琪
Owner SHANGHAI UNIV
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