A drug eluting balloon
A technology of balloons and medicines, applied in the direction of medicine equipment, stents, and other medical equipment, etc., can solve the problems of small applicable population, toxicity, and large limitations, and achieve the effect of firm coating, easy absorption, and prevention of thrombosis
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Embodiment 1
[0027] The invention provides a drug-eluting balloon, the surface of the balloon body has a drug coating, and the drug coating composition includes paclitaxel and hirudin with a mass ratio of 1:1. The medicine coating weight of described balloon is 3ug / mm 2 .
[0028] The preparation method of the drug-eluting balloon of the present invention comprises the following steps:
[0029] Step 1, taking paclitaxel and hirudin with a mass ratio of 1:1, adding the hirudin dry powder into methanol at a ratio of 6-8 mg / ml for dissolving, adding paclitaxel in a formula amount after dissolving to prepare a paclitaxel and hirudin solution;
[0030] Step 2: Spray paclitaxel and hirudin solution on the surface of the eluting balloon by vacuum spraying combined with ultrasonic atomization technology. The specific operation is as follows: first spray paclitaxel and hirudin solution to the specified weight range, and then air dry naturally for 10-30 minutes. The drug coating weight of the bal...
Embodiment 2
[0032] The invention provides a drug-eluting balloon, the surface of the balloon body has a drug coating, and the drug coating composition includes paclitaxel and hirudin with a mass ratio of 2:1. The medicine coating weight of described balloon is 3ug / mm 2 .
[0033] The preparation method of the drug-eluting balloon of the present invention comprises the following steps:
[0034] Step 1, take paclitaxel and hirudin with a mass ratio of 2:1, add paclitaxel to methanol at a ratio of 18-20 mg / ml to prepare a paclitaxel solution; add hirudin dry powder to methanol at a ratio of 6-8 mg / ml to dissolve and prepare Hirudin solution; the hirudin solution is prepared by dissolving hirudin dry powder in methanol;
[0035] Step 2: Spray paclitaxel solution and hirudin solution on the surface of the eluting balloon by vacuum spraying combined with ultrasonic atomization technology. The specific operation is as follows: first spray the paclitaxel solution to reach the specified weight ra...
Embodiment 3
[0037] The invention provides a drug-eluting balloon, the surface of the balloon body has a drug coating, and the drug coating composition includes paclitaxel and hirudin with a mass ratio of 3:1. The medicine coating weight of described balloon is 8ug / mm 2 .
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