Dipyridamole-loaded polyurethane anticoagulative material and preparation process thereof

A technology for the preparation of pyridamole polyurethane, which is applied in the field of dipyridamole-loaded polyurethane anticoagulant materials and its preparation technology, can solve the problems of limited electrospinning process and complex technical parameters of coaxial electrospinning, and achieve Improve the success rate of transplantation, avoid acute thrombosis and intimal hyperplasia, and have good uniformity

Inactive Publication Date: 2015-04-29
胡作军 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology describes making artificial blood tubes that have a special layer inside or outside them called antipyrolite (dopant). These layers help prevent clumping together of plates during surgery while still allowing enough oxygen from getting through without causing blockages like those caused when traditional methods are used. Additionally, this design prevents excessive tissue growth around these tubings which could lead to complications such as catheter occlusion. Overall, this innovative technical solution makes medical procedures more efficient and effective over longer periods.

Problems solved by technology

This patents describes different methods for preparing artificial blood tubes made up of tiny pores called diketes (small holes) within them. These techniques involve injecting special chemical substances like antifibrate agents onto the surfaces of the blood vessels' walls where they attach themselves tightly together without slip around. By doing this, the implanted devices become fixed permanently attached to the blood vessel wall while also allowing blood cells to pass freely through their passageway. Overall, these processes provide advantages compared to traditional methodologies involving filtrating plugs alone, making it possible to create complex structures containing cores and coatings filled with various types of medicines.

Method used

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  • Dipyridamole-loaded polyurethane anticoagulative material and preparation process thereof
  • Dipyridamole-loaded polyurethane anticoagulative material and preparation process thereof
  • Dipyridamole-loaded polyurethane anticoagulative material and preparation process thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0039] 1) Prepare the external fluid: dissolve 1.5g of polyurethane in 10ml of a mixed solution of tetrahydrofuran and N,N-dimethylformamide with a volume ratio of 5:5, and stir overnight;

[0040] 2) Prepare internal fluid: dissolve 30mg dipyridamole and 1.1g polycaprolactone (molecular weight 8000-10000) in 4.4g chloroform, and shake for 10 minutes;

[0041] 3) Coaxial electrospinning: inner fluid flow rate: 0.1ml / h, outer fluid flow rate: 0.7ml / h; coaxial spinning nozzle outer tube diameter 1.54mm, inner tube diameter 0.51mm; voltage: 15-20KV, ground The thread is added to the blood vessel mold, the distance between the coaxial spinning nozzle and the blood vessel mold is kept at 20 cm, and the speed of the blood vessel mold is 100 rpm; the temperature in the electrospinning box is kept at 40 ° C, and the humidity is 30% to 40%. Electrospinning time is 2 to 3 hours;

[0042] 4) After the electrospinning, the artificial blood vessel was removed from the mold and dried in va...

Embodiment 2

[0044] 1) Prepare the external fluid: dissolve 1g of polyurethane in 10ml of a mixed solution of tetrahydrofuran and N,N-dimethylformamide with a volume ratio of 7:3, and stir overnight;

[0045]2) Prepare internal fluid: dissolve 60mg of dipyridamole and 1.1g of polyethylene glycol 6000 in 4.4g of chloroform, and shake for 10 minutes;

[0046] 3) Coaxial electrospinning: inner fluid flow rate: 0.1ml / h, outer fluid flow rate: 0.7ml / h; coaxial spinning nozzle outer tube diameter 1.54mm, inner tube diameter 0.51mm; voltage: 15~20KV, ground The thread is added to the blood vessel mold, the distance between the coaxial spinning nozzle and the blood vessel mold is kept at 20 cm, and the speed of the blood vessel mold is 100 rpm; the temperature in the electrospinning box is kept at 40 ° C, and the humidity is 30% to 40%. Electrospinning time is 2 to 3 hours;

[0047] 4) After the electrospinning, the artificial blood vessel was removed from the mold and dried in vacuum at 80°C ove...

Embodiment 3

[0049] 1) Prepare the external fluid: dissolve 1.2g of polyurethane in 10ml of a mixed solution of tetrahydrofuran and N,N-dimethylformamide with a volume ratio of 3:7, and stir overnight;

[0050] 2) Prepare internal fluid: dissolve 80mg dipyridamole and 2.0g polyethylene glycol 6000 in 4.4g chloroform, shake for 10 minutes;

[0051] 3) Coaxial electrospinning: inner fluid flow rate: 0.2ml / h, outer fluid flow rate: 1.0ml / h; coaxial spinning nozzle outer tube diameter 1.54mm, inner tube diameter 0.51mm; voltage: 15-20KV, ground The thread is added to the blood vessel mold, the distance between the coaxial spinning nozzle and the blood vessel mold is kept at 20 cm, and the speed of the blood vessel mold is 100 rpm; the temperature in the electrospinning box is kept at 40 ° C, and the humidity is 30% to 40%. Electrospinning time is 2 to 3 hours;

[0052] 4) After the electrospinning, the artificial blood vessel was removed from the mold and dried in vacuum at 80°C overnight.

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Abstract

The invention discloses a dipyridamole-loaded polyurethane anticoagulative material and a preparation process thereof. The material adopts a core-shell structure, the inner layer is a dipyridamole loaded layer, and the outer layer is a polyurethane main body layer. When the material is used as an artificial blood vessel to be transplanted, the dipyridamole can be slowly released in a long term, adhesion, aggregation and activation of platelets on the surface of the artificial blood vessel are inhibited, the blood compatibility of the artificial blood vessel is improved, the acute thrombosis and intima proliferation can be effectively avoided, and the transplanting success rate of the artificial blood vessel can be effectively improved.

Description

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Claims

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Application Information

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Owner 胡作军
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