Woven vascular drug stent

A blood vessel and drug technology, applied in the field of medical devices, can solve problems such as high stenosis rate, ineffective treatment of diabetic patients, and increased risk of stent thrombosis

Inactive Publication Date: 2017-05-10
LEO MEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinical evidence shows that drug stents are still not effective in the treatment of patients with vascular disease and diabetes [JACC Cardiovasc Interv 2013;6:523–32; J Invasive Cardiol 2014;26(7):98-99]
Diabetic patients have a higher rate of stenosis after stent implantation and an increased risk of stent thrombosis (25%-80%) [N Engl JMed. 2009;361:1045-1057; N Engl J Med. 2007;357:2001-2015 ]

Method used

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  • Woven vascular drug stent
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The material of the stent wire is nickel-titanium shape memory alloy, and the metal wire is braided into a stent. The structure is as follows: figure 1 shown.

[0029] Take 0.1g of poly D, L-lactic acid (PDLLA, the weight average molecular weight range is 30,000-140,000), dissolve it in 10ml of n-propyl acetate at room temperature, and prepare a uniform solution, then add 0.1g of rapamycin Mix evenly, and accurately spray the configured solution onto the surface of the stent as the bottom layer of the drug coating of the stent. Then take 0.1g polyvinylpyrrolidone (PVP, the weight average molecular weight range is 30,000-200,000), add it to 10ml water to dissolve at room temperature, prepare a uniform solution, and spray it on the surface of the above-mentioned stent containing the bottom layer of the drug coating, as Protective top layer. The stent was dried in a vacuum oven, sterilized by ethylene oxide for use, and the coating structure was as follows: figure 2 sh...

Embodiment 2

[0032] The material of the stent wire is the same as in Example 1, and the metal wire is braided into a stent, and the structure is as follows figure 1 shown.

[0033] Take 0.1g of poly(lactic-co-glycolic acid) (poly(lactic-co-glycolic acid) (PLGA, the weight average molecular weight range is 20,000-80,000), dissolve in 10mL tetrahydrofuran at room temperature, prepare a uniform solution, and then add Mix 0.1g of paclitaxel evenly, spray the prepared solution onto the surface of the stent accurately, and use it as the bottom layer of the drug coating of the stent. The stent is dried in a vacuum oven, sterilized by ethylene oxide, and the coating structure is as follows: figure 2 shown. Then take 0.1g of polyethylene glycol (PEG, with a weight average molecular weight range of 10,000-30,000), dissolve it in 10ml of tetrahydrofuran at room temperature, prepare a uniform solution, and spray it on the surface of the stent containing the bottom layer of the drug coating as a prot...

Embodiment 3

[0036] The material of the stent wire is the same as in Example 1, and the metal wire is braided into a stent, and the structure is as follows figure 1 shown.

[0037] Take 0.1g of poly(lactic-co-glycolic acid) (poly(lactic-co-glycolic acid) (PLGA, the weight average molecular weight range is 20,000-80,000), dissolve in 10mL tetrahydrofuran at room temperature, prepare a uniform solution, and then add Mix 0.1g of paclitaxel evenly, spray the prepared solution onto the surface of the stent accurately, and use it as the bottom layer of the drug coating of the stent. The stent is dried in a vacuum oven, sterilized by ethylene oxide, and the coating structure is as follows: figure 2 shown. Then take 0.1g of polyethylene glycol (PEG, with a weight average molecular weight range of 10,000-30,000), dissolve it in 10ml of tetrahydrofuran at room temperature, and prepare a uniform solution, then add 0.1g of glibenclamide, spray to the above-mentioned drug-containing Coat the bottom ...

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PUM

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Abstract

The invention belongs to the field of medical apparatuses, and in particular relates to a vascular woven stent. The vascular woven stent comprises a woven stent main body and a coating, wherein the woven stent main body is constituted by metal wires having a shape memory function; and the coating comprises a drug coating bottom course and a protective top course. The vascular woven stent provided by the invention, by combining the woven stent, can effectively relieve coating falling, so that an acute thrombosis risk is reduced, stimulation to vascular walls and blood vessels is relieved, an occurrence rate of vascular restenosis is reduced, thrombogenesis is relieved, influence of patients' complications to the drug coating is relieved, and finally, product's effectiveness is improved.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a vascular braided stent, in particular to a vascular braided stent capable of reducing acute thrombosis, vascular restenosis, and the incidence of late vascular thrombosis. Background technique [0002] In recent years, vascular stents, as a human vascular implant, have been widely used in the treatment of coronary vessels, peripheral vessels, and intracranial vessels. For coronary vessels, 316L stainless steel, cobalt-chromium alloy or platinum-chromium alloy are often used at present, and the balloon dilation catheter is used to expand to reach the lesion. Compared with coronary arteries, the diameter of peripheral blood vessels is larger and the lesion area is longer. Self-expandable stents are often used to achieve better therapeutic effects. [0003] For self-expanding stents, there are mainly cutting stents and braided stents. After years of application, cuttin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/86A61L31/02A61L31/14A61L31/10A61L31/16
CPCA61F2/86A61F2/0077A61F2210/0014A61F2250/0067A61L31/022A61L31/10A61L31/14A61L31/148A61L31/16A61L2300/606A61L2300/802
Inventor 周奇吴常生张忠民
Owner LEO MEDICAL
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