Preparation method of medicine elution type blood vessel stent

A technology of vascular stents and drugs, which is applied in the direction of blood vessels, stents, and devices with tubular structures in the human body, can solve the problems of easy detachment of the polymer layer, achieve the effect of not easy detachment, and overcome the inability to be co-soluble in the same volatile organic solvent

Inactive Publication Date: 2006-10-11
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After the drug-eluting vascular stent prepared by this method is implanted, the functional drug is released to exert highly effective antiplatelet and anticoagulant effects at the implantation site, so as to overcome the restenosis, subacute thrombosis and polymer Layers are easy to fall off, etc.

Method used

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  • Preparation method of medicine elution type blood vessel stent
  • Preparation method of medicine elution type blood vessel stent
  • Preparation method of medicine elution type blood vessel stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A kind of operation step of preparation method of hirudin-eluting vascular stent is as follows:

[0040] (1) Preparation of butyl titanate solution

[0041]The butyl titanate solution is prepared according to the following substances and molar concentration ratios, butyl titanate: ethylene glycol methyl ether: ethyl acetoacetate: water = 0.5: 10: 0.5: 1, first add titanium to ethylene glycol methyl ether butyl ester, mix well and then add ethyl acetoacetate and water;

[0042] (2) Place the vascular stent in butyl titanate solution for processing

[0043] Soak the vascular stent in butyl titanate solution for 5 minutes, take it out and dry it at room temperature, then place it in a muffle furnace for heat treatment at 600°C, the heating rate is 8°C / min, keep it warm for 5 hours, take it out and dry it at room temperature cooling the vascular stent to form a titanium dioxide layer with a surface roughness of 0.5 μm on the surface of the vascular stent;

[0044] (3) Pr...

Embodiment 2

[0050] The operation steps of a preparation method of an anti-platelet monoclonal antibody eluting vascular stent are as follows:

[0051] (1) Preparation of butyl titanate solution

[0052] The butyl titanate solution is prepared according to the following substances and molar concentration ratios, butyl titanate: ethylene glycol methyl ether: ethyl acetoacetate: water = 3: 30: 3: 10, first add titanium to ethylene glycol methyl ether butyl ester, mix well and then add ethyl acetoacetate and water;

[0053] (2) Place the vascular stent in butyl titanate solution for processing

[0054] Soak the vascular stent in butyl titanate solution for 5 minutes, take it out, dry it at room temperature, and then place it in a muffle furnace for heat treatment at 450°C at a heating rate of 4°C / min, keep it warm for 0.5 hours, take out the stent, A titanium dioxide layer with a surface roughness of 0.1 μm is formed on the surface of the vascular stent;

[0055] (3) Preparation of polymer...

Embodiment 3

[0061] The operation steps of a method for preparing a protamine-eluting vascular stent are as follows:

[0062] (1) Preparation of butyl titanate solution

[0063] The butyl titanate solution is prepared according to the following substances and molar concentration ratios, butyl titanate: ethylene glycol methyl ether: ethyl acetoacetate: water = 2: 20: 2: 5, first add titanium to ethylene glycol methyl ether butyl ester, mix well and then add ethyl acetoacetate and water;

[0064] (2) Place the vascular stent in butyl titanate solution for processing

[0065] Soak the vascular stent in butyl titanate solution for 20 minutes, take it out and dry it at room temperature, then place it in a muffle furnace for heat treatment at 550°C at a heating rate of 6°C / min, keep it warm for 3 hours, take it out and dry it at room temperature cooling the vascular stent to form a titanium dioxide layer with a surface roughness of 0.3 μm on the surface of the vascular stent;

[0066] (3) Pre...

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Abstract

A medicine eluting blood vessel scaffold is composed of blood vessel scaffold, TiO2 layer and medicine-polymer layer. It is prepared through roughening the surface of blood vessel scaffold, generating TiO2 layer on the rough surface, coating polymer layer, and combining medicine to the polymer layer. It can prevent said scaffold from renarrowing and thrombosis.

Description

technical field [0001] The invention relates to a preparation method of a vascular stent, in particular to a preparation method of a drug-eluting vascular stent capable of releasing therapeutic drugs. The drug-eluting blood vessel stent prepared by the method can effectively prevent restenosis and thrombosis after stent implantation. Background technique [0002] In 1969, under fluoroscopy, Dotter placed a self-made stainless steel densely threaded vascular stent in the surrounding blood vessels of dogs. This stent maintained the patency of the blood vessels for two and a half years. He proved for the first time that the stainless steel vascular stent can be integrated with the vessel wall [DotlerCT . Transluminally placed coil springs and arterial tube graffs. Long-tern patency in the carinepopliteal artery. Invest Radiol, 1969, 4: 329-332]. In 1987, Sigwart et al. reported the placement of vascular stents in coronary arteries, mainly for acute vascular occlusion caused by...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/00A61L29/00A61F2/06A61M29/00A61F2/82
Inventor 王贵学尹铁英阮长耿罗贝尔·吉杜安沈阳
Owner CHONGQING UNIV
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