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Real-time extracting device and detection method for focused ultrasonic cavitation and microbubbles thereof

A technology of focused ultrasound and extraction device, which is applied in the fields of fluid pressure measurement, diagnostic recording/measurement, and medical science using acoustic methods. It can solve problems such as difficult quantification and easy coverage by fundamental waves, and achieve tissue signal suppression and detection sensitivity. high effect

Inactive Publication Date: 2009-09-16
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the technical problem that the cavitation signal in the prior art is easily covered by the fundamental wave and difficult to quantify, the present invention proposes a method and device for real-time extraction and detection of focused ultrasonic cavitation and its micro-bubbles based on pulse inversion, to realize the Ultrasonic cavitation and micro-bubble real-time identification detection

Method used

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  • Real-time extracting device and detection method for focused ultrasonic cavitation and microbubbles thereof
  • Real-time extracting device and detection method for focused ultrasonic cavitation and microbubbles thereof
  • Real-time extracting device and detection method for focused ultrasonic cavitation and microbubbles thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0040] Embodiment 1. Taking the medium degassed water as an example, observe and record the size of the cavitation threshold under different sound field parameters and different media:

[0041] use figure 1 In the experimental device, degassed water is injected into the water tank, the first cavitation receiving transducer 2 and the cavitation detection transducer 3 are both 5MHz broadband transducers, which are used to detect and receive cavitation signals respectively to complete the focus, Acquire the signal with an oscilloscope.

[0042] (1) The focused ultrasound pulse length is 10 μs, the transducer 3 adopts the pulse reversal transmission mode, the first cavitation receiving transducer 2 receives the cavitation signal, adjusts the gain of the first power amplifier 6 to 100%, and observes whether the cavitation is observed Reduce the signal and record the signal; change the gain of the power amplifier, reduce it from 100% to 5%, and record the observed signal;

[0043]...

Embodiment 2

[0047] Embodiment 2. Taking the medium degassed water as an example, the nonlinear broadband noise and subharmonics are separated from the cavitation sound signal:

[0048] use figure 2 In the experimental device, degassed water is injected into the water tank, and the first cavitation receiving transducer 2 and the second cavitation receiving transducer 2′ are 1MHz broadband transducer and 10MHz broadband transducer respectively, which are used to receive different The cavitation signal in the frequency band is fixed-focus, and the signal is collected with an acquisition card.

[0049] (1) Focused ultrasound adopts a cavitation threshold higher than that obtained in Example 1. When the focused ultrasound transducer acts but no cavitation signal is observed, the signal at this time is recorded as a background noise signal; the focused ultrasound acts and observes cavitation When the signal is recorded, the signal at this time is recorded as the cavitation sound signal;

[0...

Embodiment 3

[0053] Example 3. Extraction and comparative analysis of parameters of cavitation acoustic signals in degassed water and thrombus. Select broadband noise and sub-harmonics representing inertial cavitation and non-inertial cavitation as the research object, and observe the changes of broadband noise and sub-harmonics during the whole treatment process when focused ultrasound acts on degassed water and thrombus:

[0054] use figure 2 The experimental device is used to prepare degassed water and thrombus samples. The first cavitation receiving transducer 2 and the second cavitation receiving transducer 2′ are respectively 1MHz broadband transducer and 10MHz broadband transducer, respectively used for Receive cavitation signals of different frequency bands to complete the focus. Use the acquisition card 8 to collect signals. The external trigger signal comes from CH2 of the arbitrary waveform generator 7. The external trigger signal is triggered six times. The first five are tri...

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Abstract

The invention belongs to the technical field of ultrasonic cavitation detection and signal analysis, and relates to a method and a device for separating and detecting focused ultrasonic cavitation signals. An ultrasonic transducer of a device emits cavitation detecting signals in a pulse-inversion mode, and another ultrasonic transducer receives acoustic signals diffused by ultrasonic cavitation and movement of microbubbles; a transducer of another device generates cavitation signals in the pulse-inversion mode; for each cavitation detecting experiment, the detection method extracts background signals when the cavitation does not happen, respectively calculates power spectrums of the acquired cavitation acoustic signals and the background signals, calculates the subtracted power spectrum estimation and phase position estimation, and converts the power spectrum estimation and the phase position estimation into time domain signals to filter noise of a system; and an ICA method separates target signals such as broadband noise component, subharmonic and the like in cavitation acoustic signals from other signal components and extracts characteristic parameters of the cavitation acoustic signals. The detection method has high sensitivity and can perform quantitative analysis.

Description

technical field [0001] The invention belongs to the technical field of ultrasonic cavitation detection and analysis, and relates to a focused ultrasonic cavitation based on pulse reversal and a real-time extraction device and detection method for micro-bubbles. Background technique [0002] There are two main mechanisms of action between ultrasound and tissue: heat and cavitation. Cavitation refers to the cavitation nuclei (tiny bubbles or bubbles caused by high heat of focused ultrasound) in the liquid. A series of dynamic processes such as expansion, contraction and implosion. The cavitation process is divided into two types: ① Steady-state cavitation characterized by non-inertial cavitation. ② Transient cavitation characterized by inertial cavitation. When there are cavitation nuclei in the medium, acoustic cavitation will occur when the sound intensity exceeds a certain intensity. Violent acoustic cavitation causes high heat and high mechanical force, which may cause ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00G01L11/06
Inventor 万明习丁婷柳杨张思远
Owner XI AN JIAOTONG UNIV
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