The invention discloses a novel
drug-loaded soluble microneedle for promoting healing of
diabetic ulcer and a preparation method of the novel
drug-loaded soluble microneedle. The microneedle comprises effective component extracts in lipidosome,
hyaluronic acid,
frankincense and
myrrh. The carried
medicine is a classical
medicine pair with tissue regeneration promoting and sore astringing, namely
frankincense-
myrrh, and the key active ingredients for treating the
diabetic ulcer are screened out by adopting
artificial intelligence-based molecular docking and network target technologies, and biological
verification is carried out on the action mechanism of the key active ingredients; by adopting the
carrier system and the existing components lipidosome and
hyaluronic acid in the
organism, the material has extremely high
biocompatibility and no toxic or
side effect, and shows good stability in the subsequent test, so that the time and difficulty of clinical
medicine replacement are greatly reduced; the preparation process of the
drug-loaded microneedle is simple, conventional equipment is used, raw materials are easy to obtain, the drug-loaded microneedle is safe,
pollution-free and low in cost, economic and mental burdens of patients are relieved, and the drug-loaded microneedle has good popularization and application prospects.