The invention relates to a pH (potential of
hydrogen) responsive
graphene oxide nano-sheet coated mesoporous
silicon dioxide
drug double-loaded composite
nanoparticle and a preparation method. The pHresponsive
graphene oxide nano-sheet coated mesoporous
silicon dioxide
drug double-loaded composite
nanoparticle comprises a mesoporous
silicon dioxide
nanoparticle, cinnamyl
aldehyde, a
graphene oxide nano-sheet and adriamycin, wherein the cinnamyl
aldehyde is loaded inside the mesoporous
silicon dioxide nanoparticle, the surface of the mesoporous
silicon dioxide nanoparticle is coated with the graphene oxide nano-sheet, and the adriamycin is loaded in the structure of the graphene oxide nano-sheet. The preparation method includes the steps: loading the cinnamyl
aldehyde and the adriamycin inthe
amination mesoporous
silicon dioxide nanoparticle and the graphene oxide nano-sheet by
physical load and pi-pi conjugate; performing
electrostatic adsorption to obtain the pH responsive grapheneoxide nano-sheet coated mesoporous silicon dioxide
drug double-loaded composite nanoparticle. The prepared composite nanoparticle is good in
biocompatibility, high in drug loading capacity and less indrug release within a
neutral pH range, a surface covering layer is rapidly removed by
surface charge variation of the graphene oxide nano-sheet in a low-pH environment in a tumor
cell, drugs are released in a responsive manner,
drug accumulation in the
cell is finally improved,
drug treatment effects are enhanced, and toxic and side effects are reduced.