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PH (potential of hydrogen) responsive graphene oxide nano-sheet coated mesoporous silicon dioxide drug double-loaded composite nanoparticle and preparation method

A technology of mesoporous silica and graphene nanosheets, which can be used in drug combination, pharmaceutical formulation, drug delivery, etc., can solve problems such as cardiotoxicity, achieve low toxicity, good biocompatibility, and improve drug accumulation.

Active Publication Date: 2019-10-08
NORTHWESTERN POLYTECHNICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, DOX also has toxic and side effects such as bone marrow suppression and cardiotoxicity during clinical use.

Method used

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  • PH (potential of hydrogen) responsive graphene oxide nano-sheet coated mesoporous silicon dioxide drug double-loaded composite nanoparticle and preparation method
  • PH (potential of hydrogen) responsive graphene oxide nano-sheet coated mesoporous silicon dioxide drug double-loaded composite nanoparticle and preparation method
  • PH (potential of hydrogen) responsive graphene oxide nano-sheet coated mesoporous silicon dioxide drug double-loaded composite nanoparticle and preparation method

Examples

Experimental program
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Effect test

Embodiment

[0042] 1. Preparation of mesoporous silica nanoparticles (MSN):

[0043] Accurately weigh 2.1 g of cetyltrimethylammonium bromide (CTAB) into a 100 mL round-bottomed flask, add 52 mL of distilled water to the flask, and magnetically stir (600 rpm) in a water bath at 60°C until it becomes a transparent solution. Keep stirring, continue to dropwise add 12mL of absolute ethanol and 2.8g of triethanolamine to the above mixed solution, continue to stir for 15min, then slowly add 4.7mL of tetraethyl orthosilicate dropwise, and continue to stir in a 60°C water bath for 2h. After the reaction was completed, the solution was cooled to room temperature, and the supernatant was discarded by centrifugation (10,000 rpm, 5 min). The white solid was collected and washed repeatedly with distilled water and absolute ethanol. The cleaned sample was added to 200 mL of absolute ethanol solution containing 10% concentrated hydrochloric acid (36%), and refluxed in a water bath at 80° C. for 24 h. ...

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Abstract

The invention relates to a pH (potential of hydrogen) responsive graphene oxide nano-sheet coated mesoporous silicon dioxide drug double-loaded composite nanoparticle and a preparation method. The pHresponsive graphene oxide nano-sheet coated mesoporous silicon dioxide drug double-loaded composite nanoparticle comprises a mesoporous silicon dioxide nanoparticle, cinnamyl aldehyde, a graphene oxide nano-sheet and adriamycin, wherein the cinnamyl aldehyde is loaded inside the mesoporous silicon dioxide nanoparticle, the surface of the mesoporous silicon dioxide nanoparticle is coated with the graphene oxide nano-sheet, and the adriamycin is loaded in the structure of the graphene oxide nano-sheet. The preparation method includes the steps: loading the cinnamyl aldehyde and the adriamycin inthe amination mesoporous silicon dioxide nanoparticle and the graphene oxide nano-sheet by physical load and pi-pi conjugate; performing electrostatic adsorption to obtain the pH responsive grapheneoxide nano-sheet coated mesoporous silicon dioxide drug double-loaded composite nanoparticle. The prepared composite nanoparticle is good in biocompatibility, high in drug loading capacity and less indrug release within a neutral pH range, a surface covering layer is rapidly removed by surface charge variation of the graphene oxide nano-sheet in a low-pH environment in a tumor cell, drugs are released in a responsive manner, drug accumulation in the cell is finally improved, drug treatment effects are enhanced, and toxic and side effects are reduced.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a pH-responsive graphene oxide nanosheet-coated mesoporous silica drug double-loaded composite nanoparticle and a preparation method thereof. Background technique [0002] Tumor is one of the major diseases that threaten human health. At present, the main treatment method for malignant tumors is surgery, supplemented by comprehensive treatment such as chemotherapy and radiotherapy. Chemotherapy (chemotherapy) mainly uses chemical drugs to inhibit tumor proliferation, metastasis and ultimately kill tumors. However, most chemotherapy drugs often have many defects in clinical use, such as poor water solubility and stability, short circulation time in the body, and lack of targeting, etc., which not only affect the curative effect, but also cause serious side effects, which bring additional pain to patients. [0003] Nanotechnology is an emerging technology to study the p...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K47/52A61K31/11A61K31/704A61P35/00
CPCA61K47/6949A61K47/6923A61K47/52A61K31/11A61K31/704A61P35/00A61K2300/00Y02A50/30
Inventor 董凯卢婷利叶仙育赵壮壮
Owner NORTHWESTERN POLYTECHNICAL UNIV
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