Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of a mesoporous apatite nano drug carrier with reduction responsiveness and cell targeting to liver cancer cells

A nano-drug carrier, mesoporous apatite technology, applied in the field of biomedical materials, can solve problems such as large toxic and side effects, difficult to degrade, etc., and achieve the effects of improving effectiveness, controlling drug release, and excellent specific surface area.

Active Publication Date: 2017-10-03
HARBIN INST OF TECH
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims to solve the problem that the current drug carrier has high toxic and side effects and is difficult to degrade, and provides a method for preparing a mesoporous apatite nano drug carrier that has reduction responsiveness and cell targeting to liver cancer cells

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of a mesoporous apatite nano drug carrier with reduction responsiveness and cell targeting to liver cancer cells
  • Preparation method of a mesoporous apatite nano drug carrier with reduction responsiveness and cell targeting to liver cancer cells
  • Preparation method of a mesoporous apatite nano drug carrier with reduction responsiveness and cell targeting to liver cancer cells

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0034] Embodiment 1: A preparation method of a mesoporous apatite nano-drug carrier with reduction responsiveness and cell-targeting to liver cancer cells according to this embodiment is carried out according to the following steps:

[0035] 1. Preparation of the template agent: Dissolve the template agent F127 and calcium pantothenate monohydrate in deionized water, and stir at a stirring speed of 250r / min to 400r / min until a clear emulsion is obtained to obtain a F127-calcium pantothenate mixed solution. Promptly obtain templating agent;

[0036] The mass ratio of template agent F127 described in step one to calcium pantothenate monohydrate is 1:(4~8); the mass ratio of template agent F127 described in step one to deionized water is 1:(30~100 );

[0037] 2. Preparation of mesoporous hydroxyapatite nanoparticles: K 2 HPO 4 ·3H 2 O is dissolved in deionized water to give K 2 HPO 4 solution, followed by NH 3 ·H 2 O Mediation K 2 HPO 4 The pH value of the solution is a...

specific Embodiment approach 2

[0055] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the mass ratio of template agent F127 and calcium pantothenate monohydrate described in step 1 is 2.68:17.67. Other steps and parameters are the same as those in the first embodiment.

specific Embodiment approach 3

[0056] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the mass ratio of template agent F127 to deionized water in step 1 is 2.68:100. Other steps and parameters are the same as those in Embodiment 1 or 2.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A preparation method of mesoporous apatite nano drug carrier with reduction responsiveness and cell targeting to liver cancer cells. The invention belongs to the field of biomedical materials, and in particular relates to a method for preparing a mesoporous apatite nano-medicine carrier with reduction responsiveness and cell-targeting to liver cancer cells. The invention aims to solve the problem that the current drug carrier has large toxic and side effects and is difficult to degrade. Methods: 1. Preparation of template agent; 2. Preparation of mesoporous hydroxyapatite nanoparticles; 3. Amination of mesoporous hydroxyapatite; 4. Carboxylation of mesoporous apatite; 5. Disulfide bond Preparation of functionalized mesoporous apatite; 6. Preparation of mesoporous apatite nano drug carrier with reduction responsiveness and cell targeting. The product obtained by the invention can target and recognize liver cancer cells, reduce the uptake of drugs by normal tissues, and reduce the toxic and side effects of drugs in vivo. Regularly and quantitatively introducing the drug into the diseased tissue improves the utilization rate of the drug.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a method for preparing a mesoporous apatite nano-medicine carrier with reduction responsiveness and cell-targeting to liver cancer cells. Background technique [0002] Cancer (malignant tumor) has become one of the most important diseases threatening human health, and its incidence rate keeps increasing year by year. Currently, chemotherapy is still the most important treatment. In traditional chemotherapy methods, since anticancer drugs cannot specifically recognize target cells, the drugs are distributed in various organs in the body after entering the body, and the specific distribution to the lesion is less. These drugs have high cytotoxicity, can kill tumor cells and destroy normal tissue cells at the same time, have serious side effects, and bring great pain to patients. Therefore, it is important to construct a new type of intelligent response-controlled r...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/04A61P35/00A61P1/16
Inventor 黄玉东李大龙贺金梅程玮璐李纪伟尉枫
Owner HARBIN INST OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com