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Preparation method of mesoporous apatite nano-drug carrier with reduction responsiveness and cellular targeting property for hepatoma cell

A nano-drug carrier, mesoporous apatite technology, applied in the field of biomedical materials, can solve the problems of difficult degradation, high toxicity and side effects, and achieve the effect of improving effectiveness, reducing toxicity and side effects, and improving intake efficiency

Active Publication Date: 2015-05-06
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims to solve the problem that the current drug carrier has high toxic and side effects and is difficult to degrade, and provides a method for preparing a mesoporous apatite nano drug carrier that has reduction responsiveness and cell targeting to liver cancer cells

Method used

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  • Preparation method of mesoporous apatite nano-drug carrier with reduction responsiveness and cellular targeting property for hepatoma cell
  • Preparation method of mesoporous apatite nano-drug carrier with reduction responsiveness and cellular targeting property for hepatoma cell
  • Preparation method of mesoporous apatite nano-drug carrier with reduction responsiveness and cellular targeting property for hepatoma cell

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specific Embodiment approach 1

[0034] Embodiment 1: A preparation method of a mesoporous apatite nano-drug carrier with reduction responsiveness and cell-targeting to liver cancer cells according to this embodiment is carried out according to the following steps:

[0035] 1. Preparation of the template agent: Dissolve the template agent F127 and calcium pantothenate monohydrate in deionized water, and stir at a stirring speed of 250r / min to 400r / min until a clear emulsion is obtained to obtain a F127-calcium pantothenate mixed solution. Promptly obtain templating agent;

[0036] The mass ratio of template agent F127 described in step one to calcium pantothenate monohydrate is 1:(4~8); the mass ratio of template agent F127 described in step one to deionized water is 1:(30~100 );

[0037] 2. Preparation of mesoporous hydroxyapatite nanoparticles: K 2 HPO 4 ·3H 2 O is dissolved in deionized water to give K 2 HPO 4 solution, followed by NH 3 ·H 2 O Mediation K 2 HPO 4 The pH value of the solution is a...

specific Embodiment approach 2

[0055] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the mass ratio of template agent F127 and calcium pantothenate monohydrate described in step 1 is 2.68:17.67. Other steps and parameters are the same as those in the first embodiment.

specific Embodiment approach 3

[0056] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the mass ratio of template agent F127 to deionized water in step 1 is 2.68:100. Other steps and parameters are the same as those in Embodiment 1 or 2.

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Abstract

The invention discloses a preparation method of a mesoporous apatite nano-drug carrier with reduction responsiveness and cellular targeting property for a hepatoma cell, belonging to the field of biomedical materials. The invention aims at solving the problems that the current drug carrier is high in toxic and side effects and low in degradability. The preparation method comprises the steps of firstly, preparing a template agent; secondly, preparing a mesoporous hydroxylapatite nanoparticle; thirdly, aminating mesoporous hydroxylapatite; fourthly, carboxylating mesoporous apatite; fifthly, preparing disulfide bond functionalized mesoporous apatite; and sixthly, preparing the mesoporous apatite nano-drug carrier with reduction responsiveness and cellular targeting property. The mesoporous apatite nano-drug carrier prepared by using the preparation method can be used for recognizing hepatoma cells in a targeting way, so that the uptake of the normal tissues to the drug is reduced, and the in-vivo toxic and side effects of the drug are reduced. The drug is regularly and quantitatively introduced to pathological tissues, so that the utilization ratio of the drug is increased.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a method for preparing a mesoporous apatite nano-medicine carrier with reduction responsiveness and cell-targeting to liver cancer cells. Background technique [0002] Cancer (malignant tumor) has become one of the most important diseases threatening human health, and its incidence rate keeps increasing year by year. Currently, chemotherapy is still the most important treatment. In traditional chemotherapy methods, since anticancer drugs cannot specifically recognize target cells, the drugs are distributed in various organs in the body after entering the body, and the specific distribution to the lesion is less. These drugs have high cytotoxicity, can kill tumor cells and destroy normal tissue cells at the same time, have serious side effects, and bring great pain to patients. Therefore, it is important to construct a new type of intelligent response-controlled r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/04A61P35/00A61P1/16
Inventor 黄玉东李大龙贺金梅程玮璐李纪伟尉枫
Owner HARBIN INST OF TECH
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