Levodropropizine medicinal composition for oral cavity use

A technology of levodropropizine and its composition, which is applied in the field of chemical medicine invention, and can solve problems such as unfavorable swallowing by the elderly or children, increased drug concentration, and unstable properties, etc.

Active Publication Date: 2008-04-16
HUNAN JIUDIAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, ordinary tablets and capsules are not conducive to the elderly or children swallowing. Although the oral liquid is convenient to take, its properties are relatively unstable and troublesome to store. The dosage and pharmacokinetic properties are not as good as capsules and tablets. Therefore, the inventor studies this defect Invented a new dosage form, that is, the levodropropizine pharmaceutical composition that can be taken or chewed in the mouth can make the drug stay in the lesion, the drug concentration is relatively increased, and the action time is relatively prolonged, so as to reduce the drug dosage. The purpose of easy absorption, long storage time and improvement of therapeutic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Raw materials g

[0015] Levodropropizine 60

[0016] Meringue 120

[0017] Sucrose Powder 900

[0018] Hypromellose (15cp) 5

[0019] Menthol 15

[0020] Magnesium Stearate 5

[0021] 70% ethanol appropriate amount

[0022] The raw and auxiliary materials are crushed separately, sieved, and set aside. Weigh the raw and auxiliary materials according to the prescription quantity. First mix the excipients (except magnesium stearate and menthol), then add levodropropizine and mix well. Use 70% ethanol to make soft material, granulate, bake at 50-55°C for about 2 hours, sieve and granulate, add magnesium stearate, mix well, spray menthol 95% ethanol solution, and seal for about 6 hours. . Tablet 1000 pieces.

Embodiment 2

[0028] Raw materials g

[0029] Levodropropizine 60

[0030] β-Cyclodextrin 200

[0031] Lactose 30

[0032] Stevia 8

[0033] Magnesium Stearate 4

[0034] 5% gelatin paste appropriate amount

[0035] Crush the raw and auxiliary materials separately, sieve, and set aside; weigh the raw and auxiliary materials according to the prescription amount; dissolve β-cyclodextrin in water and add levodropropizine to grind into a paste, dry, crush, and sieve; the above mixture Mix with other excipients (except magnesium stearate), add gelatin pulp, granulate, bake, granulate, add magnesium stearate, mix evenly; compress 1000 tablets.

Embodiment 3

[0037] Raw materials g

[0038] Levodropropizine 60

[0039] Starch 360

[0040] Sucrose 60

[0041] Polyvinylpyrrolidone 5

[0042] Talc 5

[0043] 5% gelatin paste appropriate amount

[0044] Crush the raw and auxiliary materials separately, sieve, and set aside; weigh the raw and auxiliary materials according to the prescription amount; dissolve the starch in water and add levodropropizine to grind into a paste, dry, crush, and sieve; mix the above mixture with the rest of the auxiliary materials Mix evenly, add gelatin slurry, granulate, bake, granulate, and compress into 1000 pieces.

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PUM

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Abstract

A levodropropizine novel preparation is provided in the present invention, a buccal tablet capable of buccal administration and releasing slowly in oral cavity composed of levodropropizine and corresponding supplementary. The present invention leads active component levodropropizine medicine to remain at focal part to act, in oral cavity local range medicine concentration is relative heightened, so working time is prolonged relatively.

Description

field of invention [0001] The invention belongs to the field of chemical medicine invention, and relates to a pharmaceutical composition whose main component is levodropropizine, that is, a new dosage form of levodropropizine used in the oral cavity. Background technique [0002] Cough is a common clinical disease. At present, commonly used antitussive drugs mostly act on the central nervous system, such as opioid narcotic antitussive drugs morphine, codeine, etc.; Pentoxyverine, phenproperline, etc.; although there are many types of antitussives such as these, their curative effects are often unsatisfactory, and their side effects are very large. Some people think that the ideal antitussive should reduce the sensitivity of sensory nerves in the lungs and block the sensory nerve conduction in myelinated or unmyelinated nerves (such as local anesthetics), but local anesthetics can inhibit the lung defense reflex And induced side effects such as bronchoconstriction. [0003]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/495A61P11/14
Inventor 朱志宏
Owner HUNAN JIUDIAN PHARMA
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