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Preparation of polystyrene-divinylbenzene microspheres for blood purification

A technology of polystyrene and blood purification, applied in the direction of microsphere preparation, microcapsule preparation, suction equipment, etc., can solve the problems of large size dispersion of microspheres and low material utilization rate, and achieve uniform diameter dispersion, simple process, good repeatability

Inactive Publication Date: 2009-12-30
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Suspension polymerization is usually used to prepare the above-mentioned medical polymer microspheres. However, the microspheres obtained by this method have a large size dispersion and need to be sieved before use, which has the disadvantage of low material utilization.

Method used

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  • Preparation of polystyrene-divinylbenzene microspheres for blood purification
  • Preparation of polystyrene-divinylbenzene microspheres for blood purification
  • Preparation of polystyrene-divinylbenzene microspheres for blood purification

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Preparation of larger diameter polystyrene seed microspheres:

[0042] Dissolve 0.5g of hydroxypropyl cellulose and 400mg of benzoyl peroxide in a mixed solution of 30mL of absolute ethanol and 12mL of ethylene glycol methyl ether, then add 8mL of styrene monomer, and dissolve it ultrasonically at a temperature of 0-20°C to obtain Transparent solution, and replace oxygen with high-purity nitrogen bubbles for 30 minutes. Under 70 ℃ and mechanical stirring (stirring speed is 150r.p.m.) reaction 24 hours, obtain diameter about 8 micron (such as figure 1 shown) monodisperse polystyrene microspheres. After washing with ethanol for several times, the residual reactants were removed to obtain pure polystyrene microspheres, which were vacuum-dried at 40°C for 24 hours before use.

[0043] Preparation of larger diameter polystyrene-divinylbenzene crosslinked porous polymer microspheres:

[0044] 1.0g polystyrene seed microspheres (about 8μm in diameter) were uniformly dispers...

Embodiment 2

[0053] Preparation of larger diameter polystyrene seed microspheres:

[0054] Dissolve 1.0g of hydroxypropyl cellulose and 800mg of benzoyl peroxide in a mixed solution composed of 60mL of absolute ethanol and 24mL of ethylene glycol methyl ether, then add 16mL of styrene monomer, and ultrasonically dissolve at 0-20°C. A transparent solution was obtained, and deoxygenated by bubbling high-purity nitrogen for 30 min. Raise the temperature to 70° C., and react for 24 hours under mechanical stirring (stirring speed: 150 r.p.m) to obtain monodisperse polystyrene microspheres with a diameter of about 8 μm. The pure polystyrene microspheres were obtained after being washed several times with ethanol, and dried under vacuum at 40°C for 24 hours for use.

[0055] Preparation of larger diameter polystyrene-divinylbenzene crosslinked porous polymer microspheres:

[0056] 5.0g polystyrene seed microspheres (approximately 8 microns in diameter) were uniformly dispersed in 50mL containin...

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Abstract

The invention provides a method for preparing polystyrene-divinylbenzene microspheres 60 to 100 microns in diameter, and a use thereof for blood purification. Polymer microspheres prepared are synthesized by swelling and polymerizing seed emulsion. Seeds microspheres used are large-diameter linear polystyrene microspheres 6 to 8 microns in diameter. Monomer and cross-linking agent used are styrene and divinyl benzene respectively. Pore-forming agents used are toluene, ethylbenzene, o-phthalic acid lipids, n-heptane, n-octane, n-heptanol or a mixture of the substances. The polymer microspheres prepared are used to remove bilirubin during blood purification. The microspheres prepared have the characteristics of cross-linked multihole, high specific surface area (between 100 and 1,000 m<2> / g), stable mechanical strength, high yield of preparation process, use for blood purification and bilirubin adsorption, small pressure drop of adsorption column, high removal rate and the like.

Description

technical field [0001] The present invention relates to macromolecular microspheres, specifically a method for preparing polystyrene-divinylbenzene microspheres with a diameter in the range of 60-100 microns and having the characteristics of porous, cross-linked and high specific surface area and the microspheres Application in blood purification. Background technique [0002] Polymer microspheres are an important class of artificial synthetic materials, which play an important role in the fields of biochemical separation analysis, food processing, pharmaceutical industry, medical and health care, environmental protection, water treatment, synthetic chemistry and petrochemical industry. [0003] There are many ways to prepare polymer microspheres. The classic methods include suspension polymerization, dispersion polymerization, emulsion polymerization, precipitation polymerization, etc. The diameter, pore size distribution and specific surface area of ​​microspheres prepared...

Claims

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Application Information

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IPC IPC(8): B01J13/14A61M1/00
Inventor 邹汉法于志远吴仁安
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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