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Preparation method of polystyrene-divinylbenzene microspheres for bilirubin adsorption

A technology of vinylbenzene microspheres and divinylbenzene, applied in chemical instruments and methods, suction devices, alkali metal oxides/hydroxides, etc., to achieve simple preparation process, efficient adsorption or removal, and good repeatability Effect

Inactive Publication Date: 2009-02-04
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation of cross-linked polymer microspheres with monodisperse diameter, porous and high specific surface area and their application in the efficient removal of bilirubin from solution or blood have not been reported yet.

Method used

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  • Preparation method of polystyrene-divinylbenzene microspheres for bilirubin adsorption
  • Preparation method of polystyrene-divinylbenzene microspheres for bilirubin adsorption
  • Preparation method of polystyrene-divinylbenzene microspheres for bilirubin adsorption

Examples

Experimental program
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Effect test

Embodiment 1

[0045] Preparation of polystyrene seed polymer microspheres:

[0046] Dissolve 0.624g of polyvinylpyrrolidone and 290mg of azobisisobutylcyanide in 32mL of 95% (v / v) ethanol aqueous solution, add 8mL of styrene monomer, and dissolve it ultrasonically at a temperature of 0°C-20°C to obtain a transparent solution. The solution was purged with high-purity nitrogen gas for 30 minutes to replace oxygen. React at 70°C for 24 hours under mechanical stirring (stirring speed is 150r.p.m.) to obtain a diameter of about 4.8 μm (such as figure 1 shown) monodisperse polystyrene microspheres. Wash with ethanol several times to remove residual reactants to obtain pure polystyrene microspheres, which are vacuum-dried at 40°C for 24 hours before use.

[0047] Preparation of monodisperse polystyrene-divinylbenzene crosslinked porous polymer microspheres:

[0048] 0.15g seeds (about 4.8μm in diameter) are evenly dispersed in 5mL containing polyvinyl alcohol (molecular weight: 13000-23000, deg...

Embodiment 2

[0057] Preparation of polystyrene seed polymer microspheres:

[0058] Dissolve 0.624g of polyvinylpyrrolidone and 290mg of azobisisobutylcyanide in 32mL of 95% (v / v) ethanol aqueous solution, add 8mL of styrene monomer, and dissolve it ultrasonically at a temperature of 0°C-20°C to obtain a transparent solution. The solution was purged with high-purity nitrogen gas for 30 minutes to replace oxygen. React at 70°C for 24 hours under mechanical stirring (stirring speed is 150r.p.m.) to obtain a diameter of about 4.8 μm (such as figure 1 shown) monodisperse polystyrene microspheres. Wash with ethanol several times to remove residual reactants to obtain pure polystyrene microspheres, which are vacuum-dried at 40°C for 24 hours before use.

[0059] Preparation of monodisperse polystyrene-divinylbenzene crosslinked porous polymer microspheres:

[0060] 0.1 g of seed microspheres (about 4.8 μm in diameter) were uniformly dispersed in 5 mL of an aqueous solution containing 15% (w / v)...

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Abstract

The invention provides a polystyrene-divinylbenzene microsphere used for absorbing bilirubin. The diameter of the polystyrene-divinylbenzene microsphere ranges from 5 Mu M to 25 Mu M, which is controllable. The polystyrene-divinylbenzene microsphere is monodisperse and porous with the specific area from 200m<2> / g to 800m<2> / g. The polystyrene-divinylbenzene microsphere is prepared with styrene and divinylbenzene as a monomer and a cross-linking agent, as well as toluene, ethylbenzene, normal heptane, normal octane, n-heptyl alcohol or the mixture of the toluene, the ethylbenzene, the normal heptane, the normal octane and the n-heptyl alcohol as a pore-foaming agent by adopting the seed swelling polymerization method. In the method for preparing the polystyrene-divinylbenzene microsphere, seed solution and the emulsion prepared with the monomer, the cross-linking agent and the pore-foaming agent are further swollen and polymerized to get the polystyrene-divinylbenzene microsphere which is applied for absorbing bilirubin in solution or blood. The polystyrene-divinylbenzene microsphere has the advantages that the diameter of the microsphere is uniform and is controllable in a range, and the microsphere is very efficient for absorbing or removing bilirubin in solution or blood; the preparation process is simple and highly repetitive, which can be executed in large scale.

Description

technical field [0001] The invention relates to the preparation of polystyrene-divinylbenzene cross-linked porous polymer microspheres with monodisperse diameter for the adsorption of bilirubin and its application to the adsorption of bilirubin in solution or blood. Background technique [0002] Bilirubin is a metabolite of hemoglobin in red blood cells, and is one of the important indicators of whether the human liver function is normal. The removal of high levels of bilirubin in the blood is one of the focuses that the medical community has been paying attention to. The preparation of medical adsorbent materials for removing bilirubin from blood is the key technology of this focus. [0003] In the blood purification treatment method used in the treatment of severe liver disease, liver cirrhosis or neonatal hyperunconjugated bilirubinemia, the polymer microsphere resin material has a good effect on removing harmful components in the blood such as bilirubin , has been used...

Claims

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Application Information

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IPC IPC(8): C08F212/36C08F212/08C08F2/44C08F2/22B01J20/28B01J20/26A61M1/00
Inventor 邹汉法于志远吴仁安
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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