Acid corrosion resistant quenching and tempering high-strength pressure vessel steel comprises the components of, by weight, 0.05%-0.10% of C, 0.15%-0.50% of Si, 0.50%-1.20% of Mn, 0-0.008% of P, 0-0.002% of S, 0.015%-0.045% of Als, 0.20%-0.80% of Ni, 0.010%-0.030% of Ti, 0.22%-0.50% of Cu, 0.50%-1.50 % of Cr, 0.23%-0.50% of Mo and 0.002%-0.006% of Ca. A production method comprises the steps of molten iron pretreatment and converter smelting, LF furnace external refining, RH vacuum treatment, tapping and continuous casting blank forming, segmented hot rolling, quenching and tempering. According to the acid corrosion resistant quenching and tempering high-strength pressure vessel steel, after composition design, inclusion control, rolling and heat treatment, yield strength is larger than orequal to 450 MPa, tensile strength is larger than or equal to 540 MPa, elongation is larger than or equal to 20%, -40 DEG C KV2 is larger than or equal to 60 J, no hydrogen induced cracking phenomenon is generated, and stress corrosion cracking is not lower than 0.70 sigma s.