The invention provides a high-strength Al-Zn-Mg-Cu-Ce-Y-Er-La-Sc wrought aluminum alloy. The alloy is composed of, by mass, 7% of Zn, 2% of Mg, 2.3% of Cu, 0.1% of Ce, 0.5% of Y, 0.1% of Er, 0.01% of La, 0.2% of Sc and the balance Al, wherein Al, Zn, Mg and Cu are added in a form of industrial pure Al, Zn, Mg and Cu with purity larger than 99.99wt.%, and Ce, Er, Y, Sc and La are added respectively in a form of powdery rare earth alloy with Al and 30wt.% of Ce, Mg and 30wt.% of Er, Mg and 20wt.% of Y, Al and 30wt.% of La, Al and 2wt.% of Sc. The invention further provides a manufacturing method of the alloy. Good composition homogenization effect is realized by adding rare earth elements and utilizing helium to blow rare earth alloy powder in, and a protecting atmosphere is formed through helium in the process of manufacturing, so that oxidizing reaction in the process of smelting is reduced as much as possible, the formed alloy is more accurate in composition, and the problem that conventional Al-Zn-Mg-Cu alloys are insufficient in performance and have product defects is solved effectively.