Compound amino acid composition and preparation method thereof

A technology of compound amino acids and compositions, which is applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., and can solve problems such as unsuitable for popularization and application and high equipment requirements

Inactive Publication Date: 2013-09-25
四川省惠达药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The preparation method of this patent application has high requirements on equipment and is not suitable for popularization and application

Method used

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  • Compound amino acid composition and preparation method thereof
  • Compound amino acid composition and preparation method thereof
  • Compound amino acid composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] (1) Prepare 5 L of saturated aqueous solution of crude L-tryptophan at 25°C;

[0059] (2) In a sound field with a frequency of 25KHz and an output power of 40W, under the condition of nitrogen filling, add a mixed solution of isopropanol and ether at 5°C while stirring, stop the sound field after adding the mixed solution, and cool down while stirring. When the temperature was lowered to 0°C, the stirring was stopped, and the crystal was grown at 0°C for 6 hours. After the crystals were precipitated, they were washed and dried to obtain the L-tryptophan compound. Wherein, the volume of the mixed solution of isopropanol and ether added is 25L; the volume ratio of isopropanol and ether is 3:2; the adding speed of the mixed solution of added isopropanol and ether is: v 1 =250ml / min; the speed of cooling is v 2 =5°C / hour.

[0060] The X-ray powder diffraction pattern obtained by measuring the L-tryptophan compound using Cu-Kα rays is as follows: figure 1 As shown, the pu...

Embodiment 2

[0062] (1) Prepare 10L of a saturated aqueous solution of crude L-tryptophan at 30°C;

[0063] (2) In a sound field with a frequency of 25KHz and an output power of 60W, under the condition of nitrogen filling, add a mixed solution of isopropanol and ether at 0°C while stirring, stop the sound field after adding the mixed solution, and cool down while stirring. When the temperature was lowered to 0°C, the stirring was stopped, and the crystal was grown at 0°C for 2 hours. After the crystals were precipitated, the crystals were washed and dried to obtain the L-tryptophan compound. Wherein, the volume of the mixed solution of isopropanol and ether added is 30L of the saturated aqueous solution of L-tryptophan crude product; the volume ratio of isopropanol and ether is 3:1; the adding speed of the mixed solution of added isopropanol and ether is :v 1 =300ml / min; the speed of cooling is v 2 =6°C / hour.

[0064] The X-ray powder diffraction pattern obtained by measuring the L-try...

Embodiment 3

[0065] Embodiment 3: Compound Amino Acid Injection I:

[0066] Each 1000ml contains: glutamic acid 9.0g, proline 8.1g, serine 7.5g, phenylalanine 5.5g, leucine 5.3g, valine 4.3g, aspartic acid 4.1g, isoleucine Acid 3.9g, Lysine hydrochloride 4.9g, Arginine 3.3g, Threonine 3.0g, Alanine 3.0g, Histidine 2.4g, Glycine 2.1g, Methionine 1.9g, Cysteine Salt 0.145g, tryptophan compound 1.0g, tyrosine 0.5g; calcium chloride (CaCl 2.2H 2 O) 0.368g, potassium chloride (KCl) 0.375g, magnesium sulfate (MgSO 4 .7H 2 O) 0.37g, sodium hydroxide (NaOH) 2.0g, potassium hydroxide (KOH) 0.84g; sorbitol 20g, sodium bisulfite 0.01g.

[0067] The preparation method is:

[0068] 1. prepare tryptophan compound according to embodiment 1 method;

[0069] 2. Liquid preparation: Weigh the remaining 17 kinds of amino acids in proportion, add them to water for injection, then add sorbitol and sodium bisulfite to the above solution in proportion, raise the temperature to 40°C, add water for injection ...

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Abstract

The invention relates to a pharmaceutical composition, and particularly relates to a compound amino acid composition and a preparation method thereof. The compound amino acid composition contains 18 amino acids and pharmaceutical adjuvants; tryptophan is a compound as shown in an X-ray powder diffraction figure I, which is obtained by measurement with a Cu-Kalpha ray. The preparation of the compound amino acid composition, which is prepared from the tryptophan, has good stability and is very suitable for clinical application. The compound amino acid composition has very good mobility and is convenient for preparing the preparation in the medicine preparation process.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a compound amino acid composition and a preparation method thereof. Background technique [0002] Compound Amino Acid Injection is an amino acid drug, which can be used for nutritional support of patients with hypercatabolism of muscles, digestive system dysfunction, nutritional deterioration and decreased immune function under stressful conditions such as extensive burns, trauma and severe infection. It can also be used for surgery After the patient, improve its nutritional status. It is used for patients with insufficient protein intake, malabsorption and other amino acids that cannot meet the body's metabolic needs. It is also used to improve the nutritional status of patients after surgery. [0003] Since amino acids are very unstable in solution, they are easily oxidized to produce a series of complex substances harmful to the human body. Since the compound amino acid injec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4172A61P3/02C07D209/20A61K31/405
Inventor 闫晓晔
Owner 四川省惠达药业有限公司
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