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Method for preparing Ce6 embedded erythrocyte membrane coated prussian blue nanoparticle

A technology of red blood cell membrane and Prussian blue, which is applied in the field of preparation of Ce6-embedded red blood cell membrane-wrapped Prussian blue nanoparticles, which can solve the problem of no chemical activity

Active Publication Date: 2018-11-20
SOUTHWEST UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are no chemically active functional groups on the surface of Prussian blue nanoparticles, so it is difficult to modify the therapeutic functional molecules on the surface by chemical bonding.

Method used

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  • Method for preparing Ce6 embedded erythrocyte membrane coated prussian blue nanoparticle
  • Method for preparing Ce6 embedded erythrocyte membrane coated prussian blue nanoparticle
  • Method for preparing Ce6 embedded erythrocyte membrane coated prussian blue nanoparticle

Examples

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Embodiment 1

[0031] Example 1 Preparation of photosensitizer Ce6-embedded erythrocyte membrane-wrapped Prussian blue nanoparticles

[0032] Synthesis and function of Ce6-embedded erythrocyte membrane-wrapped Prussian blue nanoparticles figure 1 shown. Contains the following preparation steps:

[0033] (1) Preparation of Prussian blue nanoparticles: Dissolve 96 mg of citric acid in 20ml of 1.0mM ferric chloride and potassium ferrocyanide solution to obtain the corresponding mixed solution; Add the potassium ferricyanide solution dropwise to the ferric chloride solution containing citric acid, stir vigorously at 60°C, cool to room temperature and continue stirring for half an hour, wash with deionized water three times after centrifugation, and then Prussian blue nanoparticles (PB) were obtained.

[0034] (2) Preparation of erythrocyte membrane vesicles: Wash the mouse whole blood taken from the mouse eyeball several times with PBS until the supernatant is colorless, add sterilized second...

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Abstract

The invention relates to the field of medicine chemical synthesis and in particular relates to a method for preparing erythrocyte membrane vesica coated prussian blue nanoparticles from prussian blue,erythrocyte membrane vesicae and a photosensitizer which is finally embedded, and specific methods of different steps. The method for preparing the erythrocyte membrane vesica coated prussian blue nanoparticles with the embedded photosensitizer Ce6 specifically comprises the following steps: (1) preparing prussian blue nanoparticles; (2) preparing erythrocyte membrane vesicae; (3) embedding the photosensitizer Ce6 into the erythrocyte membrane vesicae; and (4) coating the prussian blue nanoparticles with the erythrocyte membrane vesicae into which the photosensitizer is embedded. The composite nano medicine delivery system provided by the invention has the advantages that the circulation time of medicines in bodies is increased, a large medicine carrying amount is achieved, and high biocompatibility is achieved.

Description

technical field [0001] The invention relates to the field of chemical medicines, in particular to the preparation and application of Ce6-embedded red blood cell membrane-wrapped Prussian blue nanoparticles. Background technique [0002] The efficacy of light-triggered methods is directly related to the choice of photosensitive materials. The development of photothermal conversion agents and photosensitizers with excellent properties is the key to realize efficient photothermal therapy and photodynamic therapy. With strong light absorption and high photothermal conversion efficiency in the near-infrared region, Prussian blue nanoparticles, as a photothermal preparation, have important potential in the photothermal therapy of tumors. In addition, the preparation method of Prussian blue nanoparticles is simple and has good photothermal stability. However, there are no chemically active functional groups on the surface of Prussian blue nanoparticles, so it is difficult to modi...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K41/00A61K47/46A61P35/00
CPCA61K9/5068A61K9/5084A61K41/0052A61K41/0071A61P35/00A61K2300/00
Inventor 薛鹏孙利红康跃军张蕾
Owner SOUTHWEST UNIVERSITY
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