Anti-aging composition, skin care product and preparation method thereof

Through the synergistic role of water lily extract, mulberry leaf extract and yam extract, combined with restructuring collagen and elastic protein, using the β -cycloped empty -cavity wrap technology to solve existing anti -aging products cannot deeply inhibit tyrosinic acid The problem of enzyme activity, removing free radicals and promoting collagen deep into the skin, achieve significant anti -aging effects and long -term skin firm effects.

CN119326693AInactive Publication Date: 2025-01-21JIUXIN BIOENGINEERING (SHANDONG) CO LTD

Patent Information

Application Number
CN202411349399.4
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-09-26
Publication Date
2025-01-21
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

Existing anti-aging products cannot deeply inhibit tyrosinase activity, remove free radicals, and promote peptide raw materials such as collagen to penetrate deep into the skin or promote peptide synthesis, resulting in a short effect and cannot truly affect the state of the basal cell of the skin and its inner elasticity. The content and density of protein and collagen.

Method used

Through the synergistic effects of water lilies extract, mulberry leaf extract and yam extract, combined with recombinant collagen and elastic protein, using the β -cyclical empty wrap technology to form bales to slowly release them to the surface of the skin and continue to promote collagen protein Enter the deep skin with elastic protein.

Benefits of technology

Significantly improves the anti-aging effect. Through the combination of external supplementation and internal synthesis, it significantly increases the accumulation rate of collagen in the skin, effectively reduces the number of wrinkles, and provides long-term anti-aging effects.

✦ Generated by Eureka AI based on patent content.
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Abstract

The invention relates to an anti-aging composition, a skin care product and a preparation method of the anti-aging composition and the skin care product. The anti-aging composition is prepared from the following components in parts by weight: 0.05 to 0.20 part of collagen, 0.05 to 0.20 part of elastin, 0.10 to 3.00 parts of water lily flower extract, 0.50 to 2.20 parts of folium mori extract, 0.50 to 2.40 parts of rhizoma dioscoreae extract and 1 to 10 parts of beta cyclodextrin. Compared with the prior art, the water lily extract, the mulberry leaf extract and even elastin have the capability of scavenging free radicals, and the Chinese yam extract has the capability of activating human body to synthesize collagen, so that the anti-aging effect is very remarkable through the synergistic interaction of the water lily extract, the mulberry leaf extract and even elastin; external supplement of collagen is matched with an internal synthesis effect, so that the collagen accumulation speed in the skin is greatly increased, the number of wrinkles is effectively reduced, and the anti-aging effect is improved.
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Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to an anti-aging composition, a skin care product and a preparation method thereof. Background Art

[0002] As we age, cell aging and death accumulate, and the combined influence of endogenous factors such as ultraviolet rays, oxidation, and inflammatory stress causes the gradual reduction of collagen and elastin in the skin, changes in structure and function, weakening of the skin barrier, and destruction of basal proteins, which further lead to sagging skin and wrinkles. In other words, the firmness and elasticity of the skin barrier are closely related to the degree of skin aging.

[0003] The skin barrier includes six dimensions: microbial, physical, chemical, immune, neural, and antioxidant barriers. To enhance the skin barrier, we can focus on these six dimensions, by maintaining the skin microecology, enhancing the skin stratum corneum (improving the support, stability, and elasticity of the dermis), regulating the local acid, alkali, and electrolyte homeostasis of the skin, maintaining the normal balance of inflammation-immune system, and anti-oxidation. Among them, the physical and antioxidant barriers are particularly relevant to anti-aging, and the stability of the skin barrier is the basis for supporting the firmness and elasticity of the face, which can also achieve the purpose of anti-aging. Better, compared with traditional anti-aging methods such as lifting, hydrating, and filling wrinkles on the surface, the anti-aging effects of enhancing the skin barrier, endogenous antioxidants, and endogenous and exogenous supplementation of skin matrix proteins are more fundamental and long-term.

[0004] However, many current anti-aging products can only achieve surface firming, wrinkle filling, and lifting effects, which do not last long and cannot truly affect the state of skin basal cells and the content and density of intrinsic elastin and collagen, or they use medical beauty methods that are costly and have a long recovery period.

[0005] For example, CN118178253B discloses a moisturizing and anti-aging composition and a preparation method thereof, which belongs to the field of cosmetic technology. The ingredients of the composition include bougainvillea white flower peptide, scutellaria baicalensis peptide, resurrection grass extract, sea fennel extract, avocado extract, sodium hyaluronate, propylene glycol, etc.; among them, bougainvillea white flower peptide, scutellaria baicalensis peptide and resurrection grass extract are extracted by a special extraction method of multi-stage enzymatic hydrolysis or fermentation, which can greatly improve the moisturizing and anti-aging effects of the extract.

[0006] CN118304242B discloses a skin anti-aging plant extract composition and a preparation method thereof. A skin anti-aging plant extract composition, using lactic acid-glycolic acid copolymer to wrap plant extract, then mixed with chitosan, Tween 80 and polyvinyl alcohol to prepare shell core nanobody, increase skin permeability, then mix plant essential oil with cross-linking liquid, encapsulate plant essential oil and shell core nanobody to prepare double shell core nanobody dispersion, composite plant essential oil further enhances skin permeability, and double shell core nanobody dispersion is surface modified with distearic acid acyl phosphatidylethanolamine-polyethylene glycol-N-hydroxysuccinimide to prepare plant nanofluid, and then mixed with matrix composition.

[0007] However, the above-mentioned compositions or cosmetics basically circulate on the surface of the skin and are unable to deeply inhibit tyrosinase activity, scavenge free radicals, and are unable to promote collagen and other peptide raw materials to penetrate into the skin completely or promote peptide synthesis. Summary of the invention

[0008] The purpose of the present invention is to provide an anti-aging composition, a skin care product and a preparation method thereof in order to overcome the defects of the above-mentioned prior art. The present application utilizes the stabilizing effect of water lily extract on anabolism, the free radical scavenging ability of water lily extract and mulberry leaf extract and even elastin, and the ability of yam extract to activate the body's synthesis of collagen. The three synergize to achieve a significant anti-aging effect. In addition, by combining the external supplementation of collagen with the internal synthesis effect, the speed of collagen accumulation in the skin is greatly increased, effectively reducing the number of wrinkles and improving the anti-aging effect.

[0009] The purpose of the present invention can be achieved by the following technical solutions:

[0010] In a first aspect, the present invention provides an anti-aging composition comprising, by weight, 0.05-0.20 parts of collagen, 0.05-0.20 parts of elastin, 0.10-3.00 parts of water lily extract, 0.50-2.20 parts of mulberry leaf extract, 0.50-2.40 parts of yam extract, and 1-10 parts of β-cyclodextrin.

[0011] Preferably, the preparation method of the water lily extract is as follows:

[0012] Mixing water lily and ethanol, extracting and centrifuging, collecting the supernatant, then performing rotary evaporation, dissolving in water, and then freeze-drying to obtain a water lily extract;

[0013] The preparation method of the mulberry leaf extract is as follows:

[0014] Mixing mulberry leaves and ethanol, extracting and centrifuging, collecting the supernatant, then performing rotary evaporation, dissolving in water, and then freeze-drying to obtain a mulberry leaf extract;

[0015] The preparation method of the yam extract is as follows:

[0016] Mixing yam powder and ethanol, extracting and centrifuging, collecting the supernatant, then performing rotary evaporation, dissolving in water, and then freeze-drying to obtain a yam extract;

[0017] The collagen is recombinant type III collagen;

[0018] The elastin is recombinant elastin.

[0019] Preferably, the ratio of the water lily to ethanol is 1g:1-20ml;

[0020] The ratio of the amount of mulberry leaf to ethanol is 1g:1-20ml;

[0021] The ratio of the yam powder to ethanol is 1g:1-20ml;

[0022] The specific conditions of the extraction are: at 25-40° C., ultrasonication for 15-30 min, followed by standing for 60-180 min.

[0023] In a second aspect, the present invention provides a method for preparing an anti-aging composition, comprising the following steps:

[0024] By weight, 1-10 parts of cyclodextrin are dissolved in water and stirred until it becomes transparent. Then, 0.05-0.20 parts of collagen, 0.05-0.20 parts of elastin, 0.10-3.00 parts of water lily extract, 0.50-2.20 parts of mulberry leaf extract, and 0.50-2.40 parts of yam extract are added in sequence. The mixture is stirred at room temperature for 6-10 hours to obtain a liquid phase, which is then filtered and freeze-dried to obtain an anti-aging composition.

[0025] Preferably, the preparation method of the water lily extract is as follows:

[0026] Mixing water lily and ethanol, extracting and centrifuging, collecting the supernatant, then performing rotary evaporation, dissolving in water, and then freeze-drying to obtain a water lily extract;

[0027] The preparation method of the mulberry leaf extract is as follows:

[0028] Mixing mulberry leaves and ethanol, extracting and centrifuging, collecting the supernatant, then performing rotary evaporation, dissolving in water, and then freeze-drying to obtain a mulberry leaf extract;

[0029] The preparation method of the yam extract is as follows:

[0030] Mixing yam powder and ethanol, extracting and centrifuging, collecting the supernatant, then performing rotary evaporation, dissolving in water, and then freeze-drying to obtain a yam extract;

[0031] The collagen is recombinant type III collagen;

[0032] The elastin is recombinant elastin.

[0033] Preferably, the ratio of the water lily to ethanol is 1g:1-20ml;

[0034] The ratio of the amount of mulberry leaf to ethanol is 1g:1-20ml;

[0035] The ratio of the yam powder to ethanol is 1g:1-20ml;

[0036] The specific conditions of the extraction are: at 25-40° C., ultrasonication for 15-30 min, followed by standing for 60-180 min.

[0037] In a third aspect, the present invention provides an anti-aging composition prepared by the above-mentioned method for preparing an anti-aging composition.

[0038] In a fourth aspect, the present invention provides a skin care product, wherein the skin care product contains the anti-aging composition or the anti-aging composition obtained by the preparation method of the anti-aging composition, and the anti-aging composition or the anti-aging composition obtained by the preparation method of the anti-aging composition accounts for 0.1-40% of the total mass of the skin care product;

[0039] The skin care product further comprises, by weight, 0.05-1 parts of a thickener, 0.05-1 parts of a skin conditioner, 2-10 parts of a moisturizer, 1-8 parts of an emulsifier, and the remainder of a solvent.

[0040] Preferably, the thickener includes one or more of sodium acrylate / sodium acryloyldimethyl taurate copolymer, xanthan gum, hydroxyethyl cellulose, carbomer, acrylic acid (esters) / C10-30 alkyl acrylate cross-linked polymer, and ammonium acryloyldimethyl taurate / VP copolymer;

[0041] and / or, the skin conditioning agent comprises sodium hyaluronate, allantoin or cetyl alcohol;

[0042] and / or, the moisturizer comprises glycerin, shea butter or ethylhexylglycerin;

[0043] and / or, the solvent is water;

[0044] and / or, the emulsifier comprises cetearyl glucoside and cetearyl alcohol;

[0045] And / or, the skin care product is lotion, cream, freeze-dried powder or skin care lotion.

[0046] In a fifth aspect, the present invention provides a method for preparing the above-mentioned skin care product, comprising the following steps:

[0047] Place water in a container with a stirring device and stir it, then add a thickener, a skin conditioner and a moisturizer into the water, heat it to 75-80°C, stir it thoroughly until it is completely dissolved, then add an emulsifier, stir it at 10-60rpm / min for 1-2min, then homogenize it at 2000-4000rpm / min for 3-9min, then cool the resulting mixture to 35-38°C, add the above anti-aging composition or the composition obtained by the preparation method of the above anti-aging composition, stir it at 10-60rpm / min for 1-2min, then homogenize it at 2000-4000rpm / min for 3-9min to obtain a skin care product.

[0048] Compared with the prior art, the present invention has the following beneficial effects:

[0049] 1. Compared with the prior art, the present application utilizes the cavity of cyclodextrin to wrap the water lily extract, yam extract, and mulberry leaf extract to form an embedding material, which can be slowly released to the skin surface to take effect when applied, and can continuously promote collagen and elastin to enter deep into the skin, thereby improving the moisturizing effect and anti-aging effect.

[0050] 2. The water lily extract in the present application contains bioactive substances such as tannins, flavonoids, alkaloids, anthraquinones, saponins, cardiac glycosides, phenols, etc. These active ingredients can scavenge free radicals on the skin surface and can also act as stabilizers and reducing agents. The phenolic compounds in the mulberry leaf extract have antioxidant and anti-aging effects and can scavenge free radicals. The yam extract contains p-hydroxybenzyl alcohol, p-hydroxybenzaldehyde and allantoin. These substances can enhance anabolic reactions and thus enhance the ability to synthesize collagen in the skin. Therefore, through the stabilizing effect of the water lily extract on anabolism, the free radical scavenging ability of the water lily extract and mulberry leaf extract and even elastin, and the ability of the yam extract to activate the body's synthesis of collagen, the three synergize to make the anti-aging effect very significant, and through the external supplementation of collagen and the coordination of the internal synthesis effect, the speed of collagen accumulation in the skin is greatly increased, effectively reducing the number of wrinkles and improving the anti-aging effect. DETAILED DESCRIPTION

[0051] For ease of understanding of the present application, the present application will be described more fully below by way of embodiments. However, the present application can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the understanding of the disclosure of the present application more thorough and comprehensive.

[0052] For simplicity, this application only explicitly discloses some numerical ranges. However, any lower limit can be combined with any upper limit to form an unclearly recorded range; and any lower limit can be combined with other lower limits to form an unclearly recorded range, and any upper limit can be combined with any other upper limit to form an unclearly recorded range. In addition, although not clearly recorded, each point or single value between the range endpoints is included in the range. Thus, each point or single value can be combined with any other point or single value as its own lower limit or upper limit or with other lower limits or upper limits to form an unclearly recorded range.

[0053] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those generally understood by those skilled in the art in the technical field of the present application. The terms used herein in the specification of the present application are only for the purpose of describing specific embodiments and are not intended to limit the present application. It should be noted that, unless otherwise specified, the term "and / or" used herein includes any and all combinations of one or more related listed items, and "above" and "below" include the number, and the meaning of "multiple" in "one or more" is more than two.

[0054] The efficacy of existing anti-aging or antioxidant cosmetics varies greatly. They basically circulate on the surface of the skin and are unable to deeply inhibit tyrosinase activity, scavenge free radicals, or promote collagen and other peptide raw materials to penetrate into the skin completely or promote peptide synthesis.

[0055] A first aspect of an embodiment of the present application provides an anti-aging composition, comprising, by weight, 0.05-0.20 parts of collagen, 0.05-0.20 parts of elastin, 0.10-3.00 parts of water lily extract, 0.50-2.20 parts of mulberry leaf extract, 0.50-2.40 parts of yam extract, and 1-10 parts of β-cyclodextrin.

[0056] In some optional embodiments, the preparation method of the water lily extract is as follows:

[0057] The water lily flower and ethanol are mixed, and the supernatant is collected after extraction and centrifugation, and then subjected to rotary evaporation, dissolved in water, and freeze-dried to obtain the water lily flower extract.

[0058] Optionally, the ratio of the water lily to ethanol is 1 g: 1-20 ml, preferably 1 g: 10 ml.

[0059] Optionally, the specific conditions of the extraction are: ultrasound at 25-40°C for 15-30 minutes, followed by standing for 60-180 minutes.

[0060] Preferably, the specific conditions of the extraction are: ultrasonication for 15 minutes at 25°C, followed by standing for 120 minutes.

[0061] In some optional embodiments, the preparation method of the mulberry leaf extract is as follows:

[0062] The mulberry leaves and ethanol are mixed, the supernatant is collected after extraction and centrifugation, and then the supernatant is subjected to rotary evaporation, dissolved in water, and then freeze-dried to obtain the mulberry leaf extract.

[0063] Optionally, the ratio of the mulberry leaves to ethanol is 1g:1-20ml, preferably 1g:10ml.

[0064] Optionally, the specific conditions of the extraction are: ultrasound at 25-40°C for 15-30 minutes, followed by standing for 60-180 minutes.

[0065] Preferably, the specific conditions of the extraction are: ultrasonication for 15 minutes at 25°C, followed by standing for 120 minutes.

[0066] In some optional embodiments, the preparation method of the yam extract is as follows:

[0067] The yam powder and ethanol are mixed, and the supernatant is collected after extraction and centrifugation, and then subjected to rotary evaporation, dissolved in water, and freeze-dried to obtain the yam extract.

[0068] Optionally, the ratio of the yam powder to ethanol is 1g:1-20ml, preferably 1g:10ml.

[0069] Optionally, the specific conditions of the extraction are: ultrasound at 25-40°C for 15-30 minutes, followed by standing for 60-180 minutes.

[0070] Preferably, the specific conditions of the extraction are: ultrasonication for 15 minutes at 25°C, followed by standing for 120 minutes.

[0071] It should be noted that the yam powder is specifically obtained by the following method:

[0072] The yam is dried at 60°C, crushed, and sieved (80 meshes) to obtain yam powder.

[0073] In some optional embodiments, the collagen is recombinant type III collagen. In fact, collagen is a high-grade protein whose molecules are composed of a variety of amino acids, including proline, glycine, etc. Its unique biological activity is built on the three-dimensional structure of triple superhelix. As the most abundant and widely distributed protein in the human body, collagen builds a tough support structure in the skin, bones and connective tissue, and is closely related to key processes such as maintaining the youthful state of the skin, wound healing and cell regeneration. Adult skin is mainly rich in type I collagen, while infant skin is mainly based on type III collagen, which gives the skin delicateness and elasticity. However, with age, the body's ability to synthesize type III collagen decreases, and the loss of collagen accelerates, thereby causing signs of skin aging.

[0074] In some optional embodiments, the elastin is recombinant elastin. It should be noted that elastin is the second most water-insoluble hard protein in the human body, and its structure is complex, containing more than 713 amino acid residues. These residues form two types of short peptide chains, which are arranged alternately to construct a unique elastic fiber structure, playing a key role in maintaining skin elasticity. It is mainly distributed in connective tissue, mainly giving it elastic properties, and can reach several times the original length under stretching. Elastin and collagen, elastin, glycoprotein, etc. together form the extracellular matrix (ECM) to ensure the elasticity and firmness of the skin. When elastin is missing, the muscle base tissue loses the reticular support, which leads to the appearance of skin relaxation and wrinkles. Elastin participates in the regulation of various cell behaviors, and it interacts with proteoglycans, integrins, etc., prompting various cell types (such as fibroblasts) to migrate and proliferate, triggering biological reactions. In addition, it also stimulates the synthesis of endogenous elastin, as well as the migration and differentiation of keratinocytes. However, with endogenous aging as well as external stimuli such as ultraviolet rays, elastin and the fibers it compose undergo denaturation, breakage, and loss of elasticity, which becomes one of the main signs of aging.

[0075] Moreover, recombinant elastin actually has excellent superoxide radical scavenging activity, which fundamentally slows down the occurrence of oxidative aging.

[0076] A second aspect of the present application provides a method for preparing an anti-aging composition, comprising the following steps:

[0077] By weight, 1-10 parts of cyclodextrin are dissolved in water and stirred until it becomes transparent. Then, 0.05-0.20 parts of collagen, 0.05-0.20 parts of elastin, 0.10-3.00 parts of water lily extract, 0.50-2.20 parts of mulberry leaf extract, and 0.50-2.40 parts of yam extract are added in sequence, and stirred at room temperature to obtain a liquid phase, which is then filtered and freeze-dried to obtain an anti-aging composition.

[0078] In some optional embodiments, the preparation method of the water lily extract is as follows:

[0079] The water lily flower and ethanol are mixed, and the supernatant is collected after extraction and centrifugation, and then subjected to rotary evaporation, dissolved in water, and freeze-dried to obtain the water lily flower extract.

[0080] Optionally, the ratio of the water lily to ethanol is 1 g: 1-20 ml, preferably 1 g: 10 ml.

[0081] Optionally, the specific conditions of the extraction are: ultrasound at 25-40°C for 15-30 minutes, followed by standing for 60-180 minutes.

[0082] Preferably, the specific conditions of the extraction are: ultrasonication for 15 minutes at 25°C, followed by standing for 120 minutes.

[0083] In some optional embodiments, the preparation method of the mulberry leaf extract is as follows:

[0084] The mulberry leaves and ethanol are mixed, the supernatant is collected after extraction and centrifugation, and then the supernatant is subjected to rotary evaporation, dissolved in water, and then freeze-dried to obtain the mulberry leaf extract.

[0085] Optionally, the ratio of the mulberry leaves to ethanol is 1g:1-20ml, preferably 1g:10ml.

[0086] Optionally, the specific conditions of the extraction are: ultrasound at 25-40°C for 15-30 minutes, followed by standing for 60-180 minutes.

[0087] Preferably, the specific conditions of the extraction are: ultrasonication for 15 minutes at 25°C, followed by standing for 120 minutes.

[0088] In some optional embodiments, the preparation method of the yam extract is as follows:

[0089] The yam powder and ethanol are mixed, and the supernatant is collected after extraction and centrifugation, and then subjected to rotary evaporation, dissolved in water, and freeze-dried to obtain the yam extract.

[0090] Optionally, the ratio of the yam powder to ethanol is 1g:1-20ml, preferably 1g:10ml.

[0091] Optionally, the specific conditions of the extraction are: ultrasound at 25-40°C for 15-30 minutes, followed by standing for 60-180 minutes.

[0092] Preferably, the specific conditions of the extraction are: ultrasonication for 15 minutes at 25°C, followed by standing for 120 minutes.

[0093] It should be noted that the yam powder is specifically obtained by the following method:

[0094] The yam is dried at 60°C, crushed, and sieved (80 meshes) to obtain yam powder.

[0095] In some optional embodiments, the collagen is recombinant type III collagen. In fact, collagen is a high-grade protein whose molecules are composed of a variety of amino acids, including proline, glycine, etc. Its unique biological activity is built on the three-dimensional structure of triple superhelix. As the most abundant and widely distributed protein in the human body, collagen builds a tough support structure in the skin, bones and connective tissue, and is closely related to key processes such as maintaining the youthful state of the skin, wound healing and cell regeneration. Adult skin is mainly rich in type I collagen, while infant skin is mainly based on type III collagen, which gives the skin delicateness and elasticity. However, with age, the body's ability to synthesize type III collagen decreases, and the loss of collagen accelerates, thereby causing signs of skin aging.

[0096] In some optional embodiments, the elastin is recombinant elastin. It should be noted that elastin is the second most water-insoluble hard protein in the human body, and its structure is complex, containing more than 713 amino acid residues. These residues form two types of short peptide chains, which are arranged alternately to construct a unique elastic fiber structure, playing a key role in maintaining skin elasticity. It is mainly distributed in connective tissue, mainly giving it elastic properties, and can reach several times the original length under stretching. Elastin and collagen, elastin, glycoprotein, etc. together form the extracellular matrix (ECM) to ensure the elasticity and firmness of the skin. When elastin is missing, the muscle base tissue loses the reticular support, which leads to the appearance of skin relaxation and wrinkles. Elastin participates in the regulation of various cell behaviors, and it interacts with proteoglycans, integrins, etc., prompting various cell types (such as fibroblasts) to migrate and proliferate, triggering biological reactions. In addition, it also stimulates the synthesis of endogenous elastin, as well as the migration and differentiation of keratinocytes. However, with endogenous aging as well as external stimuli such as ultraviolet rays, elastin and the fibers it compose undergo denaturation, breakage, and loss of elasticity, which becomes one of the main signs of aging.

[0097] Moreover, recombinant elastin actually has excellent superoxide radical scavenging activity, which fundamentally slows down the occurrence of oxidative aging.

[0098] The third aspect of the embodiment of the present application provides a skin care product, which contains the above-mentioned anti-aging composition or the composition obtained by the above-mentioned preparation method of the anti-aging composition, and the anti-aging composition or the composition obtained by the preparation method of the anti-aging composition accounts for 0.1-40% of the total mass of the skin care product.

[0099] In some optional embodiments, the skin care product further comprises, by weight, 0.05-1 parts of a thickener, 0.05-1 parts of a skin conditioner, 2-10 parts of a moisturizer, 1-8 parts of an emulsifier, and the remainder of a solvent.

[0100] In some optional embodiments, the thickener includes one or more of sodium acrylate / sodium acryloyldimethyl taurate copolymer, xanthan gum, hydroxyethyl cellulose, carbomer, acrylic acid (esters) / C10-30 alkyl acrylate crosspolymer, and ammonium acryloyldimethyl taurate / VP copolymer;

[0101] In some alternative embodiments, the skin conditioning agent comprises sodium hyaluronate, allantoin or cetyl alcohol.

[0102] In some optional embodiments, the moisturizer includes glycerin, shea butter or ethylhexylglycerin.

[0103] In some optional embodiments, the solvent is water.

[0104] In some alternative embodiments, the emulsifier includes cetearyl glucoside and cetearyl alcohol.

[0105] The fourth aspect of the present application provides a method for preparing the above-mentioned skin care product, which specifically comprises the following steps:

[0106] Place water in a container with a stirring device and stir it, then add a thickener, a skin conditioner and a moisturizer into the water, heat it to 75-80°C, stir it thoroughly until it is completely dissolved, then add an emulsifier, stir it at 10-60rpm / min for 1-2min, then homogenize it at 2000-4000rpm / min for 3-9min, then cool the resulting mixture to 35-38°C, add the above anti-aging composition or the composition obtained by the preparation method of the above anti-aging composition, stir it at 10-60rpm / min for 1-2min, then homogenize it at 2000-4000rpm / min for 3-9min to obtain a skin care product.

[0107] In some optional embodiments, the skin care product includes lotion, cream, freeze-dried powder or skin care water.

[0108] The above implementation is described in more detail below in conjunction with specific examples.

[0109] Example 1

[0110] This embodiment provides an emulsion, comprising the following steps:

[0111] Place water in a container with a stirring device and stir, add xanthan gum, carbomer, sodium hyaluronate, allantoin, glycerin and shea butter into the water, heat to 75-80°C, stir thoroughly until completely dissolved, then add cetearyl glucoside, stir at 10-60rpm / min for 1-2min, then homogenize at 2000-4000rpm / min for 3-9min, then cool the resulting mixture to 35-38°C, add the anti-aging composition, stir at 10-60rpm / min for 1-2min, then homogenize at 2000-4000rpm / min for 3-9min to obtain an emulsion.

[0112] Among them, the mass ratio of xanthan gum, carbomer, sodium hyaluronate, allantoin, glycerin and shea butter is 0.05:0.08:0.06:0.20:4:2, and the anti-aging composition accounts for 35% of the mass of the emulsion.

[0113] The anti-aging composition is prepared in the following manner:

[0114] By weight, 10 parts of cyclodextrin were dissolved in water and stirred until transparent. Then, 0.1 parts of recombinant type III collagen, 0.1 parts of recombinant elastin, 2.00 parts of water lily extract, 2 parts of mulberry leaf extract and 2 parts of yam extract were added in sequence. The mixture was stirred at room temperature for 6 hours to obtain a liquid phase, which was then filtered and freeze-dried to obtain an anti-aging composition.

[0115] The preparation method of the water lily extract is as follows:

[0116] 100 g of water lily and 1000 ml of ethanol were mixed, ultrasonicated for 15 min at 25° C., then allowed to stand for 120 min, centrifuged, the supernatant was collected, then rotary evaporated, dissolved in water, and freeze-dried to obtain the water lily extract.

[0117] The preparation method of mulberry leaf extract is as follows:

[0118] Mix 100 g of mulberry leaves and 1000 ml of ethanol, ultrasonicate for 15 min at 25° C., then let stand for 120 min, collect the supernatant after centrifugation, perform rotary evaporation, dissolve in water, and then freeze-dry to obtain the mulberry leaf extract.

[0119] The preparation method of yam extract is as follows:

[0120] 100 g of yam powder and 1000 ml of ethanol were mixed, ultrasonicated at 25° C. for 15 min, then allowed to stand for 120 min, centrifuged, and the supernatant was collected and then subjected to rotary evaporation, dissolved in water, and then freeze-dried to obtain the yam extract.

[0121] Example 2

[0122] This embodiment provides an emulsion, comprising the following steps:

[0123] Place water in a container with a stirring device and stir, add xanthan gum, carbomer, sodium hyaluronate, allantoin, glycerin and shea butter into the water, heat to 75-80°C, stir thoroughly until completely dissolved, then add cetearyl glucoside, stir at 10-60rpm / min for 1-2min, then homogenize at 2000-4000rpm / min for 3-9min, then cool the resulting mixture to 35-38°C, add the anti-aging composition, stir at 10-60rpm / min for 1-2min, then homogenize at 2000-4000rpm / min for 3-9min to obtain an emulsion.

[0124] Among them, the mass ratio of xanthan gum, carbomer, sodium hyaluronate, allantoin, glycerin and shea butter is 0.05:0.08:0.06:0.20:4:2, and the anti-aging composition accounts for 35% of the mass of the emulsion.

[0125] The anti-aging composition is prepared in the following manner:

[0126] By weight, 10 parts of cyclodextrin were dissolved in water and stirred until transparent. Then, 0.10 parts of recombinant type III collagen, 0.10 parts of recombinant elastin, 1 part of water lily extract, 2 parts of mulberry leaf extract and 2 parts of yam extract were added in sequence. The mixture was stirred at room temperature for 6 hours to obtain a liquid phase, which was then filtered and freeze-dried to obtain an anti-aging composition.

[0127] The preparation method of the water lily extract is as follows:

[0128] 100 g of water lily and 1000 ml of ethanol were mixed, ultrasonicated for 15 min at 25° C., then allowed to stand for 120 min, centrifuged, the supernatant was collected, then rotary evaporated, dissolved in water, and freeze-dried to obtain the water lily extract.

[0129] The preparation method of mulberry leaf extract is as follows:

[0130] Mix 100 g of mulberry leaves and 1000 ml of ethanol, ultrasonicate for 15 min at 25° C., then let stand for 120 min, collect the supernatant after centrifugation, perform rotary evaporation, dissolve in water, and then freeze-dry to obtain the mulberry leaf extract.

[0131] The preparation method of yam extract is as follows:

[0132] 100 g of yam powder and 1000 ml of ethanol were mixed, ultrasonicated at 25° C. for 15 min, then allowed to stand for 120 min, centrifuged, and the supernatant was collected and then subjected to rotary evaporation, dissolved in water, and then freeze-dried to obtain the yam extract.

[0133] Example 3

[0134] This embodiment provides an emulsion, comprising the following steps:

[0135] Place water in a container with a stirring device and stir, add xanthan gum, carbomer, sodium hyaluronate, allantoin, glycerin and shea butter into the water, heat to 75-80°C, stir thoroughly until completely dissolved, then add cetearyl glucoside, stir at 10-60rpm / min for 1-2min, then homogenize at 2000-4000rpm / min for 3-9min, then cool the resulting mixture to 35-38°C, add the anti-aging composition, stir at 10-60rpm / min for 1-2min, then homogenize at 2000-4000rpm / min for 3-9min to obtain an emulsion.

[0136] Among them, the mass ratio of xanthan gum, carbomer, sodium hyaluronate, allantoin, glycerin and shea butter is 0.05:0.08:0.06:0.20:4:2, and the anti-aging composition accounts for 35% of the mass of the emulsion.

[0137] The anti-aging composition is prepared in the following manner:

[0138] By weight, 10 parts of cyclodextrin were dissolved in water and stirred until transparent. Then, 0.10 parts of recombinant type III collagen, 0.10 parts of recombinant elastin, 3 parts of water lily extract, 2 parts of mulberry leaf extract and 2 parts of yam extract were added in sequence. The mixture was stirred at room temperature for 6 hours to obtain a liquid phase, which was then filtered and freeze-dried to obtain an anti-aging composition.

[0139] The preparation method of the water lily extract is as follows:

[0140] 100 g of water lily and 1000 ml of ethanol were mixed, ultrasonicated for 15 min at 25° C., then allowed to stand for 120 min, centrifuged, the supernatant was collected, then rotary evaporated, dissolved in water, and freeze-dried to obtain the water lily extract.

[0141] The preparation method of mulberry leaf extract is as follows:

[0142] Mix 100 g of mulberry leaves and 1000 ml of ethanol, ultrasonicate for 15 min at 25° C., then let stand for 120 min, collect the supernatant after centrifugation, perform rotary evaporation, dissolve in water, and then freeze-dry to obtain the mulberry leaf extract.

[0143] The preparation method of yam extract is as follows:

[0144] 100 g of yam powder and 1000 ml of ethanol were mixed, ultrasonicated at 25° C. for 15 min, then allowed to stand for 120 min, centrifuged, and the supernatant was collected and then subjected to rotary evaporation, dissolved in water, and then freeze-dried to obtain the yam extract.

[0145] Example 4

[0146] This embodiment provides an emulsion, comprising the following steps:

[0147] Place water in a container with a stirring device and stir, add xanthan gum, carbomer, sodium hyaluronate, allantoin, glycerin and shea butter into the water, heat to 75-80°C, stir thoroughly until completely dissolved, then add cetearyl glucoside, stir at 10-60rpm / min for 1-2min, then homogenize at 2000-4000rpm / min for 3-9min, then cool the resulting mixture to 35-38°C, add the anti-aging composition, stir at 10-60rpm / min for 1-2min, then homogenize at 2000-4000rpm / min for 3-9min to obtain an emulsion.

[0148] Among them, the mass ratio of xanthan gum, carbomer, sodium hyaluronate, allantoin, glycerin and shea butter is 0.05:0.08:0.06:0.20:4:2, and the anti-aging composition accounts for 35% of the mass of the emulsion.

[0149] The anti-aging composition is prepared in the following manner:

[0150] By weight, 10 parts of cyclodextrin were dissolved in water and stirred until transparent. Then, 0.10 parts of recombinant type III collagen, 0.10 parts of recombinant elastin, 3 parts of water lily extract, 1 part of mulberry leaf extract and 1 part of yam extract were added in sequence. The mixture was stirred at room temperature for 6 hours to obtain a liquid phase, which was then filtered and freeze-dried to obtain an anti-aging composition.

[0151] The preparation method of the water lily extract is as follows:

[0152] 100 g of water lily and 1000 ml of ethanol were mixed, ultrasonicated for 15 min at 25° C., then allowed to stand for 120 min, centrifuged, the supernatant was collected, then rotary evaporated, dissolved in water, and freeze-dried to obtain the water lily extract.

[0153] The preparation method of mulberry leaf extract is as follows:

[0154] Mix 100 g of mulberry leaves and 1000 ml of ethanol, ultrasonicate for 15 min at 25° C., then let stand for 120 min, collect the supernatant after centrifugation, perform rotary evaporation, dissolve in water, and then freeze-dry to obtain the mulberry leaf extract.

[0155] The preparation method of yam extract is as follows:

[0156] 100 g of yam powder and 1000 ml of ethanol were mixed, ultrasonicated at 25° C. for 15 min, then allowed to stand for 120 min, centrifuged, and the supernatant was collected and then subjected to rotary evaporation, dissolved in water, and then freeze-dried to obtain the yam extract.

[0157] Comparative Example 1

[0158] This comparative example provides an emulsion, comprising the following steps:

[0159] Place water in a container with a stirring device and stir, add xanthan gum, carbomer, sodium hyaluronate, allantoin, glycerin and shea butter into the water, heat to 75-80°C, stir thoroughly until completely dissolved, then add cetearyl glucoside, stir at 10-60rpm / min for 1-2min, then homogenize at 2000-4000rpm / min for 3-9min, then cool the resulting mixture to 35-38°C, add the anti-aging composition, stir at 10-60rpm / min for 1-2min, then homogenize at 2000-4000rpm / min for 3-9min to obtain an emulsion.

[0160] Among them, the mass ratio of xanthan gum, carbomer, sodium hyaluronate, allantoin, glycerin and shea butter is 0.05:0.08:0.06:0.20:4:2, and the anti-aging composition accounts for 35% of the mass of the emulsion.

[0161] The anti-aging composition is prepared in the following manner:

[0162] In parts by weight, 0.1 parts of recombinant type III collagen, 0.1 parts of recombinant elastin, 2.00 parts of water lily extract, 2 parts of mulberry leaf extract, and 2 parts of yam extract were added to water in sequence, and the mixture was stirred at room temperature for 6 hours to obtain a liquid phase, which was then filtered and freeze-dried to obtain an anti-aging composition.

[0163] The preparation method of the water lily extract is as follows:

[0164] 100 g of water lily and 1000 ml of ethanol were mixed, ultrasonicated for 15 min at 25° C., then allowed to stand for 120 min, centrifuged, the supernatant was collected, then rotary evaporated, dissolved in water, and freeze-dried to obtain the water lily extract.

[0165] The preparation method of mulberry leaf extract is as follows:

[0166] Mix 100 g of mulberry leaves and 1000 ml of ethanol, ultrasonicate for 15 min at 25° C., then let stand for 120 min, collect the supernatant after centrifugation, perform rotary evaporation, dissolve in water, and then freeze-dry to obtain the mulberry leaf extract.

[0167] The preparation method of yam extract is as follows:

[0168] 100 g of yam powder and 1000 ml of ethanol were mixed, ultrasonicated at 25° C. for 15 min, then allowed to stand for 120 min, centrifuged, and the supernatant was collected and then subjected to rotary evaporation, dissolved in water, and then freeze-dried to obtain the yam extract.

[0169] Comparative Example 2

[0170] This embodiment provides an emulsion, comprising the following steps:

[0171] Place water in a container with a stirring device and stir, add xanthan gum, carbomer, sodium hyaluronate, allantoin, glycerin and shea butter into the water, heat to 75-80°C, stir thoroughly until completely dissolved, then add cetearyl glucoside, stir at 10-60rpm / min for 1-2min, then homogenize at 2000-4000rpm / min for 3-9min, then cool the resulting mixture to 35-38°C, add the anti-aging composition, stir at 10-60rpm / min for 1-2min, then homogenize at 2000-4000rpm / min for 3-9min to obtain an emulsion.

[0172] Among them, the mass ratio of xanthan gum, carbomer, sodium hyaluronate, allantoin, glycerin and shea butter is 0.05:0.08:0.06:0.20:4:2, and the anti-aging composition accounts for 35% of the mass of the emulsion.

[0173] The anti-aging composition is prepared in the following manner:

[0174] By weight, 10 parts of cyclodextrin were dissolved in water and stirred until transparent. Then, 0.1 parts of recombinant type III collagen, 0.1 parts of recombinant elastin, 4 parts of mulberry leaf extract and 2 parts of yam extract were added in sequence. The mixture was stirred at room temperature for 6 hours to obtain a liquid phase, which was then filtered and freeze-dried to obtain an anti-aging composition.

[0175] The preparation method of mulberry leaf extract is as follows:

[0176] Mix 100 g of mulberry leaves and 1000 ml of ethanol, ultrasonicate for 15 min at 25° C., then let stand for 120 min, collect the supernatant after centrifugation, perform rotary evaporation, dissolve in water, and then freeze-dry to obtain the mulberry leaf extract.

[0177] The preparation method of yam extract is as follows:

[0178] 100 g of yam powder and 1000 ml of ethanol were mixed, ultrasonicated at 25° C. for 15 min, then allowed to stand for 120 min, centrifuged, and the supernatant was collected and then subjected to rotary evaporation, dissolved in water, and then freeze-dried to obtain the yam extract.

[0179] Comparative Example 3

[0180] This embodiment provides an emulsion, comprising the following steps:

[0181] Place water in a container with a stirring device and stir, add xanthan gum, carbomer, sodium hyaluronate, allantoin, glycerin and shea butter into the water, heat to 75-80°C, stir thoroughly until completely dissolved, then add cetearyl glucoside, stir at 10-60rpm / min for 1-2min, then homogenize at 2000-4000rpm / min for 3-9min, then cool the resulting mixture to 35-38°C, add the anti-aging composition, stir at 10-60rpm / min for 1-2min, then homogenize at 2000-4000rpm / min for 3-9min to obtain an emulsion.

[0182] Among them, the mass ratio of xanthan gum, carbomer, sodium hyaluronate, allantoin, glycerin and shea butter is 0.05:0.08:0.06:0.20:4:2, and the anti-aging composition accounts for 35% of the mass of the emulsion.

[0183] The anti-aging composition is prepared in the following manner:

[0184] By weight, 10 parts of cyclodextrin were dissolved in water and stirred until transparent. Then, 0.1 parts of recombinant type III collagen, 0.1 parts of recombinant elastin, 4.00 parts of water lily extract and 2 parts of mulberry leaf extract were added in sequence. The mixture was stirred at room temperature for 6 hours to obtain a liquid phase, which was then filtered and freeze-dried to obtain an anti-aging composition.

[0185] The preparation method of the water lily extract is as follows:

[0186] 100 g of water lily and 1000 ml of ethanol were mixed, ultrasonicated for 15 min at 25° C., then allowed to stand for 120 min, centrifuged, the supernatant was collected, then rotary evaporated, dissolved in water, and freeze-dried to obtain the water lily extract.

[0187] The preparation method of mulberry leaf extract is as follows:

[0188] Mix 100 g of mulberry leaves and 1000 ml of ethanol, ultrasonicate for 15 min at 25° C., then let stand for 120 min, collect the supernatant after centrifugation, perform rotary evaporation, dissolve in water, and then freeze-dry to obtain the mulberry leaf extract.

[0189] Comparative Example 4

[0190] This embodiment provides an emulsion, comprising the following steps:

[0191] Place water in a container with a stirring device and stir, add xanthan gum, carbomer, sodium hyaluronate, allantoin, glycerin and shea butter into the water, heat to 75-80°C, stir thoroughly until completely dissolved, then add cetearyl glucoside, stir at 10-60rpm / min for 1-2min, then homogenize at 2000-4000rpm / min for 3-9min, then cool the resulting mixture to 35-38°C, add the anti-aging composition, stir at 10-60rpm / min for 1-2min, then homogenize at 2000-4000rpm / min for 3-9min to obtain an emulsion.

[0192] Among them, the mass ratio of xanthan gum, carbomer, sodium hyaluronate, allantoin, glycerin and shea butter is 0.05:0.08:0.06:0.20:4:2, and the anti-aging composition accounts for 35% of the mass of the emulsion.

[0193] The anti-aging composition is prepared in the following manner:

[0194] By weight, 10 parts of cyclodextrin were dissolved in water and stirred until transparent. Then, 0.1 parts of recombinant type III collagen, 0.1 parts of recombinant elastin, 2.00 parts of water lily extract and 4 parts of yam extract were added in sequence. The mixture was stirred at room temperature for 6 hours to obtain a liquid phase, which was then filtered and freeze-dried to obtain an anti-aging composition.

[0195] The preparation method of mulberry leaf extract is as follows:

[0196] Mix 100 g of mulberry leaves and 1000 ml of ethanol, ultrasonicate for 15 min at 25° C., then let stand for 120 min, collect the supernatant after centrifugation, perform rotary evaporation, dissolve in water, and then freeze-dry to obtain the mulberry leaf extract.

[0197] The preparation method of yam extract is as follows:

[0198] 100 g of yam powder and 1000 ml of ethanol were mixed, ultrasonicated at 25° C. for 15 min, then allowed to stand for 120 min, centrifuged, and the supernatant was collected and then subjected to rotary evaporation, dissolved in water, and then freeze-dried to obtain the yam extract.

[0199] Test example:

[0200] 1. TEWL (g / m2 / h) transepidermal water loss test

[0201] Test subjects: 100 healthy subjects were selected. Inclusion criteria: age 25-40 years old, arm water content less than 40%, TEWL less than 15; the tested part has no hair, dermatitis or damage.

[0202] Test environment: constant temperature (20±2℃), constant humidity (relative humidity 50%±5%) environment.

[0203] Test method: 100 subjects were divided into 10 groups, with 10 subjects in each group. Each group of subjects used the products of Examples 1-3 and Comparative Examples 1-7, respectively. The transepidermal water loss (TEWL) of the subjects was measured before and at different times after using the products using a non-invasive measuring device TEWL (Dermalab Combo).

[0204] After using the test product, TEWL decreased significantly, indicating that the skin barrier was restored and the product had a repairing effect. The average TEWL change rate of each group of subjects after using the product was calculated, and the change rate = (average TEWL of 10 subjects in each group after using the product - average TEWL of 10 subjects in each group before using the product) ÷ average TEWL of 10 subjects in each group before using the product × 100%. The test results are shown in Table 1.

[0205] Table 1

[0206] Examples After using for 7 days After 30 days of use After 60 days of use Example 1 -16.21 -18.59 -26.42 Example 2 -15.76 -17.91 -24.37 Example 3 -17.45 -20.43 -28.54 Example 4 -16.76 -19.63 -27.21 Comparative Example 1 -10.48 -15.21 -19.11 Comparative Example 2 -6.34 -10.21 -14.34 Comparative Example 3 -5.89 -9.78 -13.22 Comparative Example 4 -5.12 -8.89 -11.29

[0207] As can be seen from Table 1, compared with before use, the TEWL (g / m2 / h) values ​​of the samples of Examples 1 to 4 were significantly reduced after 7d, 30d, and 60d of use, and the effects were sustained as the use time was extended.

[0208] The degree of reduction in TEWL (g / m2 / h) of the skin transepidermal water loss using Comparative Example 1 is higher than that in Example 1. This is mainly because when cyclodextrin is not added, the water lily extract, yam extract, and mulberry leaf extract basically circulate on the skin surface without having a sustained effect. When cyclodextrin is added to form the anti-aging compositions in Examples 1 to 3 of the present application, the cavity of cyclodextrin wraps up the water lily extract, yam extract, and mulberry leaf extract to form an embedding material, which can be slowly released to the skin surface to take effect when applied.

[0209] The degree of reduction in TEWL (g / m2 / h) transepidermal water loss using Comparative Examples 2, 3, and 4 is higher than that in Example 1, which mainly illustrates that the synergistic effect of the three ingredients of water lily extract, yam extract, and mulberry leaf extract is more conducive to avoiding skin moisture loss.

[0210] 2. Skin wrinkle test

[0211] Test subjects: Several volunteers were recruited, aged between 40 and 50, all female, without serious diseases, and with wrinkles on their faces. Each group consisted of 10 volunteers. After the volunteers washed their faces with clean water and dried them, the wrinkle status of their skin was measured and recorded as the initial wrinkle measurement value.

[0212] Test method: Volunteers were divided into groups and used the test samples prepared from the anti-aging composition containing collagen in each embodiment or each comparative example, once in the morning and evening, 2 ml each time, and the test samples were evenly applied on the face to completely cover the face, and the test samples were applied until they were completely absorbed and the skin was dry. Before using the test samples, wash the face with clean water and dry it, and then apply the test samples immediately.

[0213] After using the test sample for 90 days, measure the skin wrinkle status again, which is recorded as the 90-day wrinkle measurement value. Wash the face with clean water and wipe it dry before measurement.

[0214] Test instrument: The skin fast three-dimensional imaging system PRIMOS was used to measure the wrinkle status. The five locations of the left and right eye corners, the middle of the forehead, and the cheeks on both sides were tested. The measured value was the average of the five locations. The average of each group of test data was taken. The test data was rounded to two decimal places. The lower the measured value, the fewer the skin wrinkles. The results are shown in Table 2.

[0215] Table 2

[0216] Examples Initial wrinkle measurements Wrinkle measurement after 90 days Example 1 38.42 33.21 Example 2 36.45 30.89 Example 3 39.87 30.12 Example 4 37.89 32.34 Comparative Example 1 37.13 36.11 Comparative Example 2 39.28 37.65 Comparative Example 3 40.12 37.67 Comparative Example 4 39.22 36.98

[0217] As shown in Table 2, the 90d wrinkle measurement values ​​of Examples 1 to 4 are significantly lower than the 90d wrinkle measurement values ​​of Comparative Examples 1 to 4, and the reduction values ​​of the wrinkle measurement values ​​in Examples 1 to 4 are similar, indicating that the use of Examples 1 to 4 of the present application has obvious anti-aging functions, can significantly reduce wrinkles, and the composite system of the present application has significant antioxidant properties.

[0218] Compared with Example 1, Example 1 does not perform embedding, so that the water lily extract, yam extract, and mulberry leaf extract basically flow on the skin surface without a sustained effect. At this time, it is impossible to continuously promote collagen and elastin to enter deep into the skin, so that the anti-aging effect is not obvious.

[0219] Compared with Comparative Examples 2 to 4, Example 1 shows that the comparative example destroys the compound system of water lily extract, yam extract, and mulberry leaf extract, thereby reducing the effect of eliminating free radicals, so that the comparative example has limited effect in slowing down aging and delaying the formation of wrinkles. In practice, water lily extract contains tannins, flavonoids, alkaloids, anthraquinones, saponins, cardiac glycosides, phenols and other biologically active substances, which can scavenge free radicals on the skin surface and can also act as stabilizers and reducing agents. The phenolic compounds in the mulberry leaf extract have antioxidant and anti-aging effects and can scavenge free radicals. The yam extract The extract contains p-hydroxybenzyl alcohol, p-hydroxybenzaldehyde and allantoin, which can enhance anabolic reactions and thus enhance the ability to synthesize collagen in the skin. Therefore, through the stabilizing effect of water lily extract on anabolism, the ability of water lily extract and mulberry leaf extract and even elastin to scavenge free radicals, and the ability of yam extract to activate the body's synthesis of collagen, the three work synergistically to achieve a significant anti-aging effect. In addition, through the external supplementation of collagen and the coordination of the internal synthesis effect, the speed of collagen accumulation in the skin is greatly increased, effectively reducing the number of wrinkles and improving the anti-aging effect.

[0220] The above description of the embodiments is to facilitate the understanding and use of the invention by those skilled in the art. It is obvious that those skilled in the art can easily make various modifications to these embodiments and apply the general principles described herein to other embodiments without creative work. Therefore, the present invention is not limited to the above embodiments, and improvements and modifications made by those skilled in the art based on the disclosure of the present invention without departing from the scope of the present invention should be within the scope of protection of the present invention.

Claims

1. An anti-aging composition, characterized in that: The invention comprises 0.05-0.20 parts of collagen, 0.05-0.20 parts of elastin, 0.10-3.00 parts of water lily extract, 0.50-2.20 parts of mulberry leaf extract, 0.50-2.40 parts of yam extract and 1-10 parts of beta-cyclodextrin in parts by weight.

2. An anti-aging composition according to claim 1, characterized in that: The preparation method of the water lily extract is as follows: Mixing water lily and ethanol, extracting and centrifuging, collecting the supernatant, then performing rotary evaporation, dissolving in water, and then freeze-drying to obtain a water lily extract; The preparation method of the mulberry leaf extract is as follows: Mixing mulberry leaves and ethanol, extracting and centrifuging, collecting the supernatant, then performing rotary evaporation, dissolving in water, and then freeze-drying to obtain a mulberry leaf extract; The preparation method of the yam extract is as follows: Mixing yam powder and ethanol, extracting and centrifuging, collecting the supernatant, then performing rotary evaporation, dissolving in water, and then freeze-drying to obtain a yam extract; The collagen is recombinant type III collagen; The elastin is recombinant elastin.

3. An anti-aging composition according to claim 2, characterized in that: The ratio of the water lily to the ethanol is 1g:1-20ml; The ratio of the amount of mulberry leaf to ethanol is 1g:1-20ml; The ratio of the yam powder to ethanol is 1g:1-20ml; The specific conditions of the extraction are: at 25-40° C., ultrasonication for 15-30 min, followed by standing for 60-180 min.

4. A method for preparing an anti-aging composition, characterized in that: The following steps are involved: By weight, 1-10 parts of cyclodextrin are dissolved in water and stirred until it becomes transparent. Then, 0.05-0.20 parts of collagen, 0.05-0.20 parts of elastin, 0.10-3.00 parts of water lily extract, 0.50-2.20 parts of mulberry leaf extract, and 0.50-2.40 parts of yam extract are added in sequence. The mixture is stirred at room temperature for 6-10 hours to obtain a liquid phase, which is then filtered and freeze-dried to obtain an anti-aging composition.

5. The method for preparing an anti-aging composition according to claim 4, characterized in that: The preparation method of the water lily extract is as follows: Mixing water lily and ethanol, extracting and centrifuging, collecting the supernatant, then performing rotary evaporation, dissolving in water, and then freeze-drying to obtain a water lily extract; The preparation method of the mulberry leaf extract is as follows: Mixing mulberry leaves and ethanol, extracting and centrifuging, collecting the supernatant, then performing rotary evaporation, dissolving in water, and then freeze-drying to obtain a mulberry leaf extract; The preparation method of the yam extract is as follows: Mixing yam powder and ethanol, extracting and centrifuging, collecting the supernatant, then performing rotary evaporation, dissolving in water, and then freeze-drying to obtain a yam extract; The collagen is recombinant type III collagen; The elastin is recombinant elastin.

6. The method for preparing an anti-aging composition according to claim 5, characterized in that: The ratio of the water lily to the ethanol is 1g:1-20ml; The ratio of the amount of mulberry leaf to ethanol is 1g:1-20ml; The ratio of the yam powder to ethanol is 1g:1-20ml; The specific conditions of the extraction are: at 25-40° C., ultrasonication for 15-30 min, followed by standing for 60-180 min.

7. An anti-aging composition obtained by the method for preparing the anti-aging composition according to any one of claims 4 to 6.

8. A skin care product, characterized in that: The skin care product contains the anti-aging composition according to any one of claims 1 to 3 or the anti-aging composition obtained by the preparation method of the anti-aging composition according to claim 7, and the anti-aging composition or the anti-aging composition obtained by the preparation method of the anti-aging composition accounts for 0.1-40% of the total mass of the skin care product; The skin care product further comprises, by weight, 0.05-1 parts of a thickener, 0.05-1 parts of a skin conditioner, 2-10 parts of a moisturizer, 1-8 parts of an emulsifier, and the remainder of a solvent.

9. A skin care product according to claim 8, characterized in that The thickener includes one or more of sodium acrylate / sodium acryloyldimethyl taurate copolymer, xanthan gum, hydroxyethyl cellulose, carbomer, acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer, and ammonium acryloyldimethyl taurate / VP copolymer; and / or, the skin conditioning agent comprises sodium hyaluronate, allantoin or cetyl alcohol; and / or, the moisturizer comprises glycerin, shea butter or ethylhexylglycerin; and / or, the solvent is water; and / or, the emulsifier comprises cetearyl glucoside and cetearyl alcohol; And / or, the skin care product is lotion, cream, freeze-dried powder or skin care lotion.

10. A method for preparing a skin care product according to claim 8 or 9, characterized in that: The steps include: Place water in a container with a stirring device and stir it, then add a thickener, a skin conditioner and a moisturizer into the water, heat it to 75-80°C, stir it thoroughly until it is completely dissolved, then add an emulsifier, stir it at 10-60rpm / min for 1-2min, then homogenize it at 2000-4000rpm / min for 3-9min, then cool the resulting mixture to 35-38°C, add the above anti-aging composition or the composition obtained by the preparation method of the above anti-aging composition, stir it at 10-60rpm / min for 1-2min, then homogenize it at 2000-4000rpm / min for 3-9min to obtain a skin care product.

Citation Information

Patent Citations

  • Moisturizing and anti-aging composition and preparation method thereof

    CN118178253B

  • Skin whitening cosmetic product containing aloe extract, mulberry leaf extract and Chinese yam extract

    CN105456090A

  • Collagen-containing anti-aging composition and application thereof

    CN117414311A

  • Composition with barrier enhancing and anti-aging effects as well as preparation method and application thereof

    CN117679348A

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